Search Results - "BURDETTE, Doug" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics

by Billington, Sarah, Salphati, Laurent, Hop, Cornelis E C A, Chu, Xiaoyan, Evers, Raymond, Burdette, Doug, Rowbottom, Christopher, Lai, Yurong, Xiao, Guangqing, Humphreys, W Griffith, Nguyen, Tot Bui, Prasad, Bhagwat, Unadkat, Jashvant D
Published in Clinical pharmacology and therapeutics (01.07.2019)

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Journal Article

P3 - Optimization of the sample collection procedures for selective BCRP inhibitor, KO143, in rodents

P3 - Optimization of the sample collection procedures for selective BCRP inhibitor, KO143, in rodents

by Pietrasiewicz, Alicia, Rowbottom, Christopher, Veizaj, Elvana, Burdette, Doug
Published in Drug metabolism and pharmacokinetics (2020)

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Journal Article

P131 - Optimization and validation of rodent chemical knock out model for P-glycoprotein using the selective inhibitor, valspodar, and application to internal cut-off values and calibration of MDCK-MDR1 Cell line

P131 - Optimization and validation of rodent chemical knock out model for P-glycoprotein using the selective inhibitor, valspodar, and application to internal cut-off values and calibration of MDCK-MDR1 Cell line

by Rowbottom, Christopher, Pietrasiewicz, Alicia, Viezaj, Elvana, Tuczkewycz, Taras, Grater, Richard, Kapadnis, Sudarshan, Burdette, Doug, Qiu, Daniel
Published in Drug metabolism and pharmacokinetics (2020)

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In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

by JIAN YU, BROWN, Dean G, BURDETTE, Doug
Published in Drug metabolism and disposition (01.10.2010)

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Journal Article

Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor

Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor

by Dhamne, Sameer C, Modi, Meera E, Gray, Audrey, Bonazzi, Simone, Craig, Lucas, Bainbridge, Elizabeth, Lalani, Lahin, Super, Chloe E, Schaeffer, Samantha, Capre, Ketthsy, Lubicka, Danuta, Liang, Guiqing, Burdette, Doug, McTighe, Stephanie M, Gurnani, Sarika, Vermudez, Sheryl Anne D, Curtis, Daniel, Wilson, Christopher J, Hameed, Mustafa Q, D'Amore, Angelica, Rotenberg, Alexander, Sahin, Mustafa
Published in Annals of clinical and translational neurology (01.10.2023)

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Journal Article

Thermozymes

Thermozymes

by Vieille, Claire, Burdette, Doug S., Zeikus, J. Gregory
Published in Biotechnology Annual Review (1996)

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Book Chapter Journal Article

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

by Hopkins, Brian T, Bame, Eris, Bajrami, Bekim, Black, Cheryl, Bohnert, Tonika, Boiselle, Carrie, Burdette, Doug, Burns, Jeremy C, Delva, Luisette, Donaldson, Douglas, Grater, Richard, Gu, Chungang, Hoemberger, Marc, Johnson, Josh, Kapadnis, Sudarshan, King, Kris, Lulla, Mukesh, Ma, Bin, Marx, Isaac, Magee, Tom, Meissner, Robert, Metrick, Claire M, Mingueneau, Michael, Murugan, Paramasivam, Otipoby, Kevin L, Polack, Evelyne, Poreci, Urjana, Prince, Robin, Roach, Allie M, Rowbottom, Chris, Santoro, Joseph C, Schroeder, Patricia, Tang, Hao, Tien, Eric, Zhang, Fengmei, Lyssikatos, Joseph
Published in Journal of medicinal chemistry (27.01.2022)

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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

by Bonazzi, Simone, Goold, Carleton P, Gray, Audrey, Thomsen, Noel M, Nunez, Jill, Karki, Rajeshri G, Gorde, Aakruti, Biag, Jonathan D, Malik, Hasnain A, Sun, Yingchuan, Liang, Guiqing, Lubicka, Danuta, Salas, Sarah, Labbe-Giguere, Nancy, Keaney, Erin P, McTighe, Stephanie, Liu, Shanming, Deng, Lin, Piizzi, Grazia, Lombardo, Franco, Burdette, Doug, Dodart, Jean-Cosme, Wilson, Christopher J, Peukert, Stefan, Curtis, Daniel, Hamann, Lawrence G, Murphy, Leon O
Published in Journal of medicinal chemistry (13.02.2020)

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Journal Article

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes

by Bonazzi, Simone, Gray, Audrey, Thomsen, Noel M., Biag, Jonathan, Labbe-Giguere, Nancy, Keaney, Erin P., Malik, Hasnain A., Sun, Yingchuan, Nunez, Jill, Karki, Rajeshri G., Knapp, Mark, Elling, Robert, Fuller, John, Pardee, Gwynn, Craig, Lucas, Capre, Ketthsy, Salas, Sarah, Gorde, Aakruti, Liang, Guiqing, Lubicka, Danuta, McTighe, Stephanie M., Goold, Carleton, Liu, Shanming, Deng, Lin, Hong, Jin, Fekete, Alexander, Stadelmann, Pascal, Frieauff, Wilfried, Elhajouji, Azeddine, Bauer, Daniel, Lerchner, Andreas, Radetich, Branko, Furet, Pascal, Piizzi, Grazia, Burdette, Doug, Wilson, Christopher J., Peukert, Stefan, Hamann, Lawrence G., Murphy, Leon O., Curtis, Daniel
Published in Journal of medicinal chemistry (13.07.2023)

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Journal Article

Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry

Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry

by Zhang, Minli, Eismin, Ryan, Kenttämaa, Hilkka, Xiong, Hui, Wu, Ye, Burdette, Doug, Urbanek, Rebecca
Published in Drug metabolism and disposition (01.03.2015)

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Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening

Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening

by Yu, Jian, Folmer, James J, Hoesch, Valerie, Doherty, James, Campbell, James B, Burdette, Doug
Published in Drug metabolism and disposition (01.02.2011)

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Journal Article

Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine

Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine

by Yu, Jian, Mathisen, Donald E, Burdette, Doug, Brown, Dean G, Becker, Christopher, Aharony, David
Published in Drug metabolism and disposition (01.01.2010)

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Journal Article

P1‐363: MONITORING THE SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA (SAPPA) AND BETA (SAPPB) FRAGMENTS IN PLASMA AND CSF FROM HEALTHY INDIVIDUALS TREATED WITH BACE INHIBITOR AZD3293 IN A MULTIPLE ASCENDING DOSE STUDY: PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATE

P1‐363: MONITORING THE SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA (SAPPA) AND BETA (SAPPB) FRAGMENTS IN PLASMA AND CSF FROM HEALTHY INDIVIDUALS TREATED WITH BACE INHIBITOR AZD3293 IN A MULTIPLE ASCENDING DOSE STUDY: PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATE

by Höglund, Kina, Salter, Hugh, Zetterberg, Henrik, Andreason, Ulf, Olsson, Tina, Alexander, Robert, Kugler, Alan, Cebers, Gvido, Ye, Naidong, Burdette, Doug, Budd Haeberlein, Samantha L.
Published in Alzheimer's & dementia (01.07.2014)

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Journal Article

MONITORING THE SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA (SAPPA) AND BETA (SAPPB) FRAGMENTS IN PLASMA AND CSF FROM HEALTHY INDIVIDUALS TREATED WITH BACE INHIBITOR AZD3293 IN A MULTIPLE ASCENDING DOSE STUDY: PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATE

MONITORING THE SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA (SAPPA) AND BETA (SAPPB) FRAGMENTS IN PLASMA AND CSF FROM HEALTHY INDIVIDUALS TREATED WITH BACE INHIBITOR AZD3293 IN A MULTIPLE ASCENDING DOSE STUDY: PHARMACOKINETIC AND PHARMACODYNAMIC CORRELATE

by Höglund, Kina, Salter, Hugh, Zetterberg, Henrik, Andreason, Ulf, Olsson, Tina, Alexander, Robert, Kugler, Alan, Cebers, Gvido, Ye, Naidong, Burdette, Doug, Budd Haeberlein, Samantha L
Published in Alzheimer's & dementia (01.07.2014)

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Journal Article

Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring OpeningS

Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring OpeningS

by JIAN YU, FOLMER, James J, HOESCH, Valerie, DOHERTY, James, CAMPBELL, James B, BURDETTE, Doug
Published in Drug metabolism and disposition (2011)

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Journal Article

Identification of Multiple Glutathione Conjugates of 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisopuinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine

Identification of Multiple Glutathione Conjugates of 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisopuinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine

by JIAN YU, MATHISEN, Donald E, BURDETTE, Doug, BROWN, Dean G, BECKER, Christopher, AHARONY, David
Published in Drug metabolism and disposition (2010)

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Journal Article