Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Davis, Karen D., Aghaeepour, Nima, Ahn, Andrew H., Angst, Martin S., Borsook, David, Brenton, Ashley, Burczynski, Michael E., Crean, Christopher, Edwards, Robert, Gaudilliere, Brice, Hergenroeder, Georgene W., Iadarola, Michael J., Iyengar, Smriti, Jiang, Yunyun, Kong, Jiang-Ti, Mackey, Sean, Saab, Carl Y., Sang, Christine N., Scholz, Joachim, Segerdahl, Marta, Tracey, Irene, Veasley, Christin, Wang, Jing, Wager, Tor D., Wasan, Ajay D., Pelleymounter, Mary Ann
Published in Nature reviews. Neurology (01.07.2020)
Published in Nature reviews. Neurology (01.07.2020)
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Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression
Allantaz, Florence, Cheng, Donavan T, Bergauer, Tobias, Ravindran, Palanikumar, Rossier, Michel F, Ebeling, Martin, Badi, Laura, Reis, Bernhard, Bitter, Hans, D'Asaro, Matilde, Chiappe, Alberto, Sridhar, Sriram, Pacheco, Gonzalo Duran, Burczynski, Michael E, Hochstrasser, Denis, Vonderscher, Jacky, Matthes, Thomas
Published in PloS one (20.01.2012)
Published in PloS one (20.01.2012)
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Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants
Katz, Arie, Udata, Chandrasekhar, Ott, Elyssa, Hickey, Lisa, Burczynski, Michael E, Burghart, Peter, Vesterqvist, Ole, Meng, Xu
Published in Journal of clinical pharmacology (01.06.2009)
Published in Journal of clinical pharmacology (01.06.2009)
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Journal Article
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
Su, Qi, Kim, Sun Y., Adewale, Funmi, Zhou, Ye, Aldler, Christina, Ni, Min, Wei, Yi, Burczynski, Michael E., Atwal, Gurinder S., Sleeman, Mark W., Murphy, Andrew J., Xin, Yurong, Cheng, Xiping
Published in iScience (19.11.2021)
Published in iScience (19.11.2021)
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Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Kusko, Rebecca, Dreymann, Jennifer, Ross, Jermaine, Cha, Yoonjeong, Escalante-Chong, Renan, Garcia-Miralles, Marta, Tan, Liang Juin, Burczynski, Michael E, Zeskind, Ben, Laifenfeld, Daphna, Pouladi, Mahmoud, Geva, Michal, Grossman, Iris, Hayden, Michael R
Published in Molecular neurodegeneration (21.05.2018)
Published in Molecular neurodegeneration (21.05.2018)
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Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact
Goodsaid, Federico M, Amur, Shashi, Aubrecht, Jiri, Burczynski, Michael E, Carl, Kevin, Catalano, Jennifer, Charlab, Rosane, Close, Sandra, Cornu-Artis, Catherine, Essioux, Laurent, Fornace, Albert J, Hinman, Lois, Hong, Huixiao, Hunt, Ian, Jacobson-Kram, David, Jawaid, Ansar, Laurie, David, Lesko, Lawrence, Li, Heng-Hong, Lindpaintner, Klaus, Mayne, James, Morrow, Peter, Papaluca-Amati, Marisa, Robison, Timothy W, Roth, John, Schuppe-Koistinen, Ina, Shi, Leming, Spleiss, Olivia, Tong, Weida, Truter, Sharada L, Vonderscher, Jacky, Westelinck, Agnes, Zhang, Li, Zineh, Issam
Published in Nature reviews. Drug discovery (01.06.2010)
Published in Nature reviews. Drug discovery (01.06.2010)
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Biomarkers in the pharmaceutical industry
Laterza, Omar F, Plump, Andrew, Ming, Jeffrey E, Richards, Susan, Burczynski, Michael E Ransom, Wagner, John A, Patterson, Scott D
Published in Clinical chemistry (Baltimore, Md.) (01.04.2015)
Published in Clinical chemistry (Baltimore, Md.) (01.04.2015)
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Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells
Burczynski, Michael E., Peterson, Ron L., Twine, Natalie C., Zuberek, Krystyna A., Brodeur, Brendan J., Casciotti, Lori, Maganti, Vasu, Reddy, Padma S., Strahs, Andrew, Immermann, Fred, Spinelli, Walter, Schwertschlag, Ulrich, Slager, Anna M., Cotreau, Monette M., Dorner, Andrew J.
Published in The Journal of molecular diagnostics : JMD (01.02.2006)
Published in The Journal of molecular diagnostics : JMD (01.02.2006)
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An Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy Subjects
PATRONEVA, Albena, CONNOLLY, Sandra M, FATATO, Penny, PEDERSEN, Ron, QIN JIANG, PAUL, Jeffrey, GUICO-PABIA, Christine, ISLER, Jennifer A, BURCZYNSKI, Michael E, NICHOLS, Alice I
Published in Drug metabolism and disposition (01.12.2008)
Published in Drug metabolism and disposition (01.12.2008)
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Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones
Penning, Trevor M, Burczynski, Michael E, Hung, Chien-Fu, McCoull, Kirsten D, Palackal, Nisha T, Tsuruda, Laurie S
Published in Chemical research in toxicology (01.01.1999)
Published in Chemical research in toxicology (01.01.1999)
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Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma
BURCZYNSKI, Michael E, TWINE, Natalie C, STRAHS, Andrew, IMMERMANN, Fred, SLONIM, Donna K, DORNER, Andrew J, DUKART, Gary, MARSHALL, Bonnie, HIDALGO, Manuel, STADLER, Walter M, LOGAN, Theodore, DUTCHER, Janice, HUDES, Gary, TREPICCHIO, William L
Published in Clinical cancer research (01.02.2005)
Published in Clinical cancer research (01.02.2005)
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Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
Coughlin, Christina M, Johnston, Daniel S, Strahs, Andrew, Burczynski, Michael E, Bacus, Sarah, Hill, Jason, Feingold, Jay M, Zacharchuk, Charles, Berkenblit, Anna
Published in Breast cancer research and treatment (01.11.2010)
Published in Breast cancer research and treatment (01.11.2010)
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Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
Zhou, Ye, Zhao, Yuanqi, Carbonaro, Marisa, Chen, Helen, Germino, Mary, Adler, Christina, Ni, Min, Zhu, Yuan O., Kim, Sun Y., Altarejos, Judith, Li, Zhe, Burczynski, Michael E., Glass, David J., Sleeman, Mark W., Lee, Ann-Hwee, Halasz, Gabor, Cheng, Xiping
Published in Metabolism, clinical and experimental (01.05.2024)
Published in Metabolism, clinical and experimental (01.05.2024)
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Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
DiBlasio-Smith, Elizabeth A, Arai, Maya, Quinet, Elaine M, Evans, Mark J, Kornaga, Tad, Basso, Michael D, Chen, Liang, Feingold, Irene, Halpern, Anita R, Liu, Qiang-Yuan, Nambi, Ponnal, Savio, Dawn, Wang, Shuguang, Mounts, William M, Isler, Jennifer A, Slager, Anna M, Burczynski, Michael E, Dorner, Andrew J, LaVallie, Edward R
Published in Journal of translational medicine (16.10.2008)
Published in Journal of translational medicine (16.10.2008)
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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study
Ozen, Ahmet, Chongsrisawat, Voranush, Sefer, Asena Pinar, Kolukisa, Burcu, Jalbert, Jessica J, Meagher, Karoline A, Brackin, Taylor, Feldman, Hagit Baris, Baris, Safa, Karakoc-Aydiner, Elif, Ergelen, Rabia, Fuss, Ivan J, Moorman, Heather, Suratannon, Narissara, Suphapeetiporn, Kanya, Perlee, Lorah, Harari, Olivier A, Yancopoulos, George D, Lenardo, Michael J, Miller, Jutta L., Eshach Adiv, Orly, Bilgic Eltan, Sevgi, Yorgun Altunbas, Melek, Magliocco, Mary, Matthews, Helen, Marciano, Beatriz E., Chatchatee, Pantipa, Trbovic, Caryn F., Burczynski, Michael E., Chaudhari, Umesh, Usta, Yusuf, Altuntaş, Cansu, Yavuz, Sibel, Baştürk, Ahmet, Demirbaş Ar, Fatma, Topal, Erdem, Kalaycı, Ayhan Gazi, Weerapakorn, Wanlapa, Calabi Martínez, Ana Andrea, Bottero, Adriana
Published in The Lancet (British edition) (17.02.2024)
Published in The Lancet (British edition) (17.02.2024)
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Journal Article
Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione
Burczynski, Michael E, Harvey, Ronald G, Penning, Trevor M
Published in Biochemistry (Easton) (12.05.1998)
Published in Biochemistry (Easton) (12.05.1998)
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Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model
Mao, Xia, Chen, Helen, Lin, Allen Z., Kim, Sun, Burczynski, Michael E., Na, Erqian, Halasz, Gabor, Sleeman, Mark W., Murphy, Andrew J., Okamoto, Haruka, Cheng, Xiping
Published in Journal of inherited metabolic disease (01.05.2022)
Published in Journal of inherited metabolic disease (01.05.2022)
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration
Lakshman, Kishore M., Bhasin, Shalender, Corcoran, Christopher, Collins-Racie, Lisa A., Tchistiakova, Lioudmila, Forlow, S. Bradley, St. Ledger, Katie, Burczynski, Michael E., Dorner, Andrew J., LaVallie, Edward R.
Published in Molecular and cellular endocrinology (10.04.2009)
Published in Molecular and cellular endocrinology (10.04.2009)
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