Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors
Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Broad-Spectrum Efficacy across Cognitive Domains by alpha 7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Bitner, Robert S, Bunnelle, William H, Anderson, David J, Briggs, Clark A, Buccafusco, Jerry, Curzon, Peter, Decker, Michael W, Frost, Jennifer M, Gronlien, Jens Halvard, Gubbins, Earl, Li, Jinhe, Malysz, John, Markosyan, Stella, Marsh, Kennan, Meyer, Michael D, Nikkel, Arthur L, Radek, Richard J, Robb, Holly M, Timmermann, Daniel, Sullivan, James P, Gopalakrishnan, Murali
Published in The Journal of neuroscience (26.09.2007)
Published in The Journal of neuroscience (26.09.2007)
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In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile
Malysz, John, Grønlien, Jens Halvard, Anderson, David J, Håkerud, Monika, Thorin-Hagene, Kirsten, Ween, Hilde, Wetterstrand, Caroline, Briggs, Clark A, Faghih, Ramin, Bunnelle, William H, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors
Briggs, Clark A, Grønlien, Jens Halvard, Curzon, Peter, Timmermann, Daniel B, Ween, Hilde, Thorin‐Hagene, Kirsten, Kerr, Paige, Anderson, David J, Malysz, John, Dyhring, Tino, Olsen, Gunnar M, Peters, Dan, Bunnelle, William H, Gopalakrishnan, Murali
Published in British journal of pharmacology (01.11.2009)
Published in British journal of pharmacology (01.11.2009)
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Role of alpha 7 nicotinic acetylcholine receptors in regulating tumor necrosis factor- alpha (TNF- alpha ) as revealed by subtype selective agonists
Li, Jinhe, Mathieu, Suzanne L, Harris, Richard, Ji, Jianguo, Anderson, David J, Malysz, John, Bunnelle, William H, Waring, Jeffrey F, Marsh, Kennan C, Murtaza, Anwar, Olson, Lisa M, Gopalakrishnan, Murali
Published in Journal of neuroimmunology (28.10.2011)
Published in Journal of neuroimmunology (28.10.2011)
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Journal Article
SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R, Sippy, Kevin B, Briggs, Clark A, Anderson, David J, Li, Tao, Ji, Jianguo, Frost, Jennifer M, Surowy, Carol S, Bunnelle, William H, Gopalakrishnan, Murali, Meyer, Michael D
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists
Li, Jinhe, Mathieu, Suzanne L, Harris, Richard, Ji, Jianguo, Anderson, David J, Malysz, John, Bunnelle, William H, Waring, Jeffrey F, Marsh, Kennan C, Murtaza, Anwar, Olson, Lisa M, Gopalakrishnan, Murali
Published in Journal of neuroimmunology (28.10.2011)
Published in Journal of neuroimmunology (28.10.2011)
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Synthesis and evaluation of new radioligands [11 C]A-833834 and [11 C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors
Horti, Andrew G, Ravert, Hayden T, Gao, Yongjun, Holt, Daniel P, Bunnelle, William H, Schrimpf, Michael R, Li, Tao, Ji, Jianguo, Valentine, Heather, Scheffel, Ursula, Kuwabara, Hiroto, Wong, Dean F, Dannals, Robert F
Published in Nuclear medicine and biology (01.04.2013)
Published in Nuclear medicine and biology (01.04.2013)
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Synthesis and Structure−Activity Studies on N-[5-(1H-Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α1A-Adrenoceptor Agonist
Altenbach, Robert J, Khilevich, Albert, Kolasa, Teodozyj, Rohde, Jeffrey J, Bhatia, Pramila A, Patel, Meena V, Searle, Xenia B, Yang, Fan, Bunnelle, William H, Tietje, Karin, Bayburt, Erol K, Carroll, William A, Meyer, Michael D, Henry, Rodger, Buckner, Steven A, Kuk, Jane, Daza, Anthony V, Milicic, Ivan V, Cain, John C, Kang, Chae H, Ireland, Lynne M, Carr, Tracy L, Miller, Thomas R, Hancock, Arthur A, Nakane, Masaki, Esbenshade, Timothy A, Brune, Michael E, O'Neill, Alyssa B, Gauvin, Donna M, Katwala, Sweta P, Holladay, Mark W, Brioni, Jorge D, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors
SIPPY, Kevin B, ANDERSON, David J, BUNNELLE, William H, HUTCHINS, Charles W, SCHRIMPF, Michael R
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists
Ji, Jianguo, Schrimpf, Michael R, Sippy, Kevin B, Bunnelle, William H, Li, Tao, Anderson, David J, Faltynek, Connie, Surowy, Carol S, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D
Published in Journal of medicinal chemistry (01.11.2007)
Published in Journal of medicinal chemistry (01.11.2007)
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Structure–Activity Studies of Diazabicyclo[3.3.0]octane-Substituted Pyrazines and Pyridines as Potent α4β2 Nicotinic Acetylcholine Receptor Ligands
Scanio, Marc J. C, Shi, Lei, Bunnelle, William H, Anderson, David J, Helfrich, Rosalind J, Malysz, John, Thorin-Hagene, Kirsten K, Van Handel, Ceclia E, Marsh, Kennan C, Lee, Chih-Hung, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
Ji, Jianguo, Bunnelle, William H., Anderson, David J., Faltynek, Connie, Dyhring, Tino, Ahring, Philip K., Rueter, Lynne E., Curzon, Peter, Buckley, Michael J., Marsh, Kennan C., Kempf-Grote, Anita, Meyer, Michael D.
Published in Biochemical pharmacology (15.10.2007)
Published in Biochemical pharmacology (15.10.2007)
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A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]- heptane alpha 4 beta 2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
Ji, Jianguo, Bunnelle, William H, Anderson, David J, Faltynek, Connie, Dyhring, Tino, Ahring, Philip K, Rueter, Lynne E, Curzon, Peter, Buckley, Michael J, Marsh, Kennan C, Kempf-Grote, Anita, Meyer, Michael D
Published in Biochemical pharmacology (15.10.2007)
Published in Biochemical pharmacology (15.10.2007)
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