2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
Banerjee, Soojay, Bartesaghi, Alberto, Merk, Alan, Rao, Prashant, Bulfer, Stacie L., Yan, Yongzhao, Green, Neal, Mroczkowski, Barbara, Neitz, R. Jeffrey, Wipf, Peter, Falconieri, Veronica, Deshaies, Raymond J., Milne, Jacqueline L. S., Huryn, Donna, Arkin, Michelle, Subramaniam, Sriram
Published in Science (American Association for the Advancement of Science) (19.02.2016)
Published in Science (American Association for the Advancement of Science) (19.02.2016)
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Journal Article
Altered cofactor regulation with disease-associated p97/VCP mutations
Zhang, Xiaoyi, Gui, Lin, Zhang, Xiaoyan, Bulfer, Stacie L., Sanghez, Valentina, Wong, Daniel E., Lee, YouJin, Lehmann, Lynn, Lee, James Siho, Shih, Pei-Yin, Lin, Henry J., Iacovino, Michelina, Weihl, Conrad C., Arkin, Michelle R., Wang, Yanzhuang, Chou, Tsui-Fen
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
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Journal Article
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains
Chou, Tsui-Fen, Bulfer, Stacie L, Weihl, Conrad C, Li, Kelin, Lis, Lev G, Walters, Michael A, Schoenen, Frank J, Lin, Henry J, Deshaies, Raymond J, Arkin, Michelle R
Published in Journal of molecular biology (29.07.2014)
Published in Journal of molecular biology (29.07.2014)
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Journal Article
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)
Caldwell, Timothy M., Ahn, Yu Mi, Bulfer, Stacie L., Leary, Cynthia B., Hood, Molly M., Lu, Wei-Ping, Vogeti, Lakshminarayana, Vogeti, Subha, Kaufman, Michael D., Wise, Scott C., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors
Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Journal Article
Crystal structure of Saccharomyces cerevisiae Aro8, a putative α‐aminoadipate aminotransferase
Bulfer, Stacie L., Brunzelle, Joseph S., Trievel, Raymond C.
Published in Protein science (01.10.2013)
Published in Protein science (01.10.2013)
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Journal Article
Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97
Alverez, Celeste, Arkin, Michelle R, Bulfer, Stacie L, Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G, Lim, Chaemin, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M, Wipf, Peter
Published in ACS medicinal chemistry letters (10.12.2015)
Published in ACS medicinal chemistry letters (10.12.2015)
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Journal Article
A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site
Burnett, James C., Lim, Chaemin, Peyser, Brian D., Samankumara, Lalith P., Kovaliov, Marina, Colombo, Raffaele, Bulfer, Stacie L., LaPorte, Matthew G., Hermone, Ann R., McGrath, Connor F., Arkin, Michelle R., Gussio, Rick, Huryn, Donna M., Wipf, Peter
Published in Organic & biomolecular chemistry (16.05.2017)
Published in Organic & biomolecular chemistry (16.05.2017)
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Journal Article
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97
LaPorte, Matthew G, Burnett, James C, Colombo, Raffaele, Bulfer, Stacie L, Alverez, Celeste, Chou, Tsui-Fen, Neitz, R. Jeffrey, Green, Neal, Moore, William J, Yue, Zhizhou, Li, Shan, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Journal Article
Structural Basis for l-Lysine Feedback Inhibition of Homocitrate Synthase
Bulfer, Stacie L., Scott, Erin M., Pillus, Lorraine, Trievel, Raymond C.
Published in The Journal of biological chemistry (02.04.2010)
Published in The Journal of biological chemistry (02.04.2010)
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Journal Article
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP
Chimenti, Michael S, Bulfer, Stacie L, Neitz, R Jeffrey, Renslo, Adam R, Jacobson, Matthew P, James, Thomas L, Arkin, Michelle R, Kelly, Mark J S
Published in Journal of biomolecular screening (01.07.2015)
Published in Journal of biomolecular screening (01.07.2015)
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Journal Article
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Abstract 3925: Inhibition of oncogenic and drug-resistant PDGFRA and KIT alterations by DCC-2618
Smith, Bryan D., Kaufman, Michael D., Gupta, Anu, Leary, Cynthia B., Lu, Wei-ping, Bulfer, Stacie L., Al-Ani, Gada, Singh, Jarnail, Vogeti, Subha, Heinrich, Michael C., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract B129: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers
Smith, Bryan D, Vogeti, Lakshminarayana, Gupta, Anu, Singh, Jarnail, Al-Ani, Gada, Bulfer, Stacie L, Caldwell, Timothy M, Timson, Mary J, Vogeti, Subha, Ahn, Yu Mi, Al-Hashimi, Hikmat, Crawley, Chase K, Heiniger, Cale L, Leary, Cynthia B, Proto, Justin T, Shen, Quanrong, Telikepalli, Hanumaiah, Yates, Karen, Lu, Wei-Ping, Flynn, Daniel L
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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