Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment
Jackson, Jeffrey J, Ketcham, John M, Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P, Bui, Minna H. T, Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X, Jacobson, Scott, Karbarz, Emily, Kassner, Paul D, Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K, Robles, Omar, Shunatona, Hunter P, Talay, Oezcan, Walker, James R, Wadsworth, Angela, Wustrow, David J, Zibinsky, Mikhail
Published in Journal of medicinal chemistry (11.07.2019)
Published in Journal of medicinal chemistry (11.07.2019)
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Journal Article
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T-reg Trafficking into the Tumor Microenvironment
Jackson, Jeffrey J., Ketcham, John M., Younai, Ashkaan, Abraham, Betty, Biannic, Berenger, Beck, Hilary P., Bui, Minna H. T., Chian, David, Cutler, Gene, Diokno, Raymond, Hu, Dennis X., Jacobson, Scott, Karbarz, Emily, Kassner, Paul D., Marshall, Lisa, McKinnell, Jenny, Meleza, Cesar, Okal, Abood, Pookot, Deepa, Reilly, Maureen K., Robles, Omar, Shunatona, Hunter P., Talay, Oezcan, Walker, James R., Wadsworth, Angela, Wustrow, David J., Zibinsky, Mikhail
Published in Journal of medicinal chemistry (11.07.2019)
Published in Journal of medicinal chemistry (11.07.2019)
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Journal Article
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists
Zhong, Min, Hanan, Emily J., Shen, Wang, Bui, Minna, Arkin, Michelle R., Barr, Kenneth J., Evanchik, Marc J., Hoch, Ute, Hyde, Jennifer, Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors
Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Journal Article
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity
Leger, Paul R, Hu, Dennis X, Biannic, Berenger, Bui, Minna, Han, Xinping, Karbarz, Emily, Maung, Jack, Okano, Akinori, Osipov, Maksim, Shibuya, Grant M, Young, Kyle, Higgs, Christopher, Abraham, Betty, Bradford, Delia, Cho, Cynthia, Colas, Christophe, Jacobson, Scott, Ohol, Yamini M, Pookot, Deepa, Rana, Payal, Sanchez, Jerick, Shah, Niket, Sun, Michael, Wong, Steve, Brockstedt, Dirk G, Kassner, Paul D, Schwarz, Jacob B, Wustrow, David J
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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COMPOUNDS FOR TREATMENT OF KINASE-DEPENDENT DISORDERS
YONG WANG, JIANG FAMING, LYNNE CANNE BANNEN, BUI MINNA, XU WEI, TSO KIN
Year of Publication 26.07.2023
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Year of Publication 26.07.2023
Patent
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy
Jackson, Jeffrey J., Shibuya, Grant M., Ravishankar, Buvana, Adusumilli, Lavanya, Bradford, Delia, Brockstedt, Dirk G., Bucher, Cyril, Bui, Minna, Cho, Cynthia, Colas, Christoph, Cutler, Gene, Dukes, Adrian, Han, Xinping, Hu, Dennis X., Jacobson, Scott, Kassner, Paul D., Katibah, George E., Ko, Michelle Yoo Min, Kolhatkar, Urvi, Leger, Paul R., Ma, Anqi, Marshall, Lisa, Maung, Jack, Ng, Andrew A., Okano, Akinori, Pookot, Deepa, Poon, Daniel, Ramana, Chandru, Reilly, Maureen K., Robles, Omar, Schwarz, Jacob B., Shakhmin, Anton A., Shunatona, Hunter P., Sreenivasan, Raashi, Tivitmahaisoon, Parcharee, Xu, Mengshu, Zaw, Thant, Wustrow, David J., Zibinsky, Mikhail
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Marcotte, Douglas, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Otipoby, Kevin L., Poreci, Urjana, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (01.07.2019)
Published in Bioorganic & medicinal chemistry (01.07.2019)
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Journal Article
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
Hopkins, Brian T., Bame, Eris, Bell, Noah, Bohnert, Tonika, Bowden-Verhoek, Jon K., Bui, Minna, Cancilla, Mark T., Conlon, Patrick, Cullen, Patrick, Erlanson, Daniel A., Fan, Junfa, Fuchs-Knotts, Tarra, Hansen, Stig, Heumann, Stacey, Jenkins, Tracy J., Gua, Chuck, Liu, Ying, Liu, YuTing, Lulla, Mukush, Marcotte, Douglas, Marx, Isaac, McDowell, Bob, Mertsching, Elisabeth, Negrou, Ella, Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Yang, Wenjin, Zhong, Min
Published in Bioorganic & medicinal chemistry (15.08.2021)
Published in Bioorganic & medicinal chemistry (15.08.2021)
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Abstract 4752: EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists
Talay, Oezcan, Jorapur, Aparna, Jacobson, Scott, Marubayashi, Sachie, Marshall, Lisa, Suthram, Silpa, Robles, Omar, Ketcham, John, Reilly, Maureen K., Younai, Ashkaan, Biannic, Berenger, Hu, Dennis, Bui, Minna, Schwarz, Jacob, Kassner, Paul, Cutler, Gene
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Synthesis and SAR study of potent and selective PI3Kδ inhibitors
Bui, Minna, Hao, Xiaolin, Shin, Youngsook, Cardozo, Mario, He, Xiao, Henne, Kirk, Suchomel, Julia, McCarter, John, McGee, Lawrence R., San Miguel, Tisha, Medina, Julio C., Mohn, Deanna, Tran, Thuy, Wannberg, Sharon, Wong, Jamie, Wong, Simon, Zalameda, Leeanne, Metz, Daniela, Cushing, Timothy D.
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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키나제-의존성 장애의 치료용 화합물
JIANG FAMING, BUI MINNA, BANNEN LYNNE CANNE, WANG YONG, XU WEI, TSO KIN
Year of Publication 07.10.2020
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Year of Publication 07.10.2020
Patent
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye
Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin
Published in ACS medicinal chemistry letters (08.03.2012)
Published in ACS medicinal chemistry letters (08.03.2012)
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Discovery of a potent and selective Aurora kinase inhibitor
Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Journal Article
케모카인 수용체 조절제 및 이의 용도
BIANNIC BERENGER, SHUNATONA HUNTER PAUL, BUI MINNA HUE THANH, REILLY MAUREEN KAY, JACKSON JEFFREY JAMES, HU DENNIS X, BECK HILARY PLAKE, KETCHAM JOHN MICHAEL, POWERS JAY PATRICK, WALKER JAMES ROSS, ROBLES RESENDIZ OMAR, YOUNAI ASHKAAN, WUSTROW DAVID JUERGEN, ZIBINSKY MIKHAIL
Year of Publication 22.04.2019
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Year of Publication 22.04.2019
Patent
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists
Zhong, Min, Shen, Wang, Barr, Kenneth J., Arbitrario, Jennifer P., Arkin, Michelle R., Bui, Minna, Chen, Teresa, Cunningham, Brian C., Evanchik, Marc J., Hanan, Emily J., Hoch, Ute, Huen, Karen, Hyde, Jennifer, Kumer, Jeffery L., Lac, Teresa, Lawrence, Chris E., Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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