Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis
Dobie, Ross, Wilson-Kanamori, John R., Henderson, Beth E.P., Smith, James R., Matchett, Kylie P., Portman, Jordan R., Wallenborg, Karolina, Picelli, Simone, Zagorska, Anna, Pendem, Swetha V., Hudson, Thomas E., Wu, Minnie M., Budas, Grant R., Breckenridge, David G., Harrison, Ewen M., Mole, Damian J., Wigmore, Stephen J., Ramachandran, Prakash, Ponting, Chris P., Teichmann, Sarah A., Marioni, John C., Henderson, Neil C.
Published in Cell reports (Cambridge) (12.11.2019)
Published in Cell reports (Cambridge) (12.11.2019)
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Journal Article
Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function
Huang, Qunhua, Zhou, Huanjiao Jenny, Zhang, Haifeng, Huang, Yan, Hinojosa-Kirschenbaum, Ford, Fan, Peidong, Yao, Lina, Belardinelli, Luiz, Tellides, George, Giordano, Frank J, Budas, Grant R, Min, Wang
Published in Circulation (New York, N.Y.) (24.03.2015)
Published in Circulation (New York, N.Y.) (24.03.2015)
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Journal Article
Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart
Chen, Che-Hong, Budas, Grant R, Churchill, Eric N, Disatnik, Marie-Hélène, Hurley, Thomas D, Mochly-Rosen, Daria
Published in Science (American Association for the Advancement of Science) (12.09.2008)
Published in Science (American Association for the Advancement of Science) (12.09.2008)
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Journal Article
ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension
Budas, Grant R, Boehm, Mario, Kojonazarov, Baktybek, Viswanathan, Gayathri, Tian, Xia, Veeroju, Swathi, Novoyatleva, Tatyana, Grimminger, Friedrich, Hinojosa-Kirschenbaum, Ford, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Liles, John T, Schermuly, Ralph T
Published in American journal of respiratory and critical care medicine (01.02.2018)
Published in American journal of respiratory and critical care medicine (01.02.2018)
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Journal Article
ASK1 contributes to fibrosis and dysfunction in models of kidney disease
Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, Ford, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model
Schwabl, Philipp, Hambruch, Eva, Budas, Grant R, Supper, Paul, Burnet, Michael, Liles, John T, Birkel, Manfred, Brusilovskaya, Ksenia, Königshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J, Trauner, Michael, Breckenridge, David G, Kremoser, Claus, Reiberger, Thomas
Published in Biomedicines (09.01.2021)
Published in Biomedicines (09.01.2021)
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Journal Article
Activation of PKCε-ALDH2 Axis Prevents 4-HNE-Induced Pain in Mice
Martins, Bárbara B, Hösch, Natália G, Alcantara, Queren A, Budas, Grant R, Chen, Che-Hong, Mochly-Rosen, Daria, Ferreira, Julio C B, Zambelli, Vanessa O
Published in Biomolecules (Basel, Switzerland) (30.11.2021)
Published in Biomolecules (Basel, Switzerland) (30.11.2021)
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Journal Article
Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension
Wilson, Kathryn S., Buist, Hanna, Suveizdyte, Kornelija, Liles, John T., Budas, Grant R., Hughes, Colin, MacLean, Margaret R., Johnson, Martin, Church, Alistair C., Peacock, Andrew J., Welsh, David J.
Published in Pulmonary circulation (01.04.2020)
Published in Pulmonary circulation (01.04.2020)
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Journal Article
Chronic Mild Hypoxia Protects Heart-derived H9c2 Cells against Acute Hypoxia/Reoxygenation by Regulating Expression of the SUR2A Subunit of the ATP-sensitive K+ Channel
Crawford, Russell M., Jovanović, Sofija, Budas, Grant R., Davies, Anthony M., Lad, Harish, Wenger, Roland H., Robertson, Kevin A., Roy, Douglas J., Ranki, Harri J., Jovanović, Aleksandar
Published in The Journal of biological chemistry (15.08.2003)
Published in The Journal of biological chemistry (15.08.2003)
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Journal Article
Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors
Cazanave, Sophie C, Warren, Andrew D, Pacula, Maciej, Touti, Fayçal, Zagorska, Anna, Gural, Nil, Huang, Eric K, Sherman, Sarah, Cheema, Mehar, Ibarra, Sabrina, Bates, Jamie, Billin, Andrew N, Liles, John T, Budas, Grant R, Breckenridge, David G, Tiniakos, Dina, Ratziu, Vlad, Daly, Ann K, Govaere, Olivier, Anstee, Quentin M, Gelrud, Louis, Luther, Jay, Chung, Raymond T, Corey, Kathleen E, Winckler, Wendy, Bhatia, Sangeeta, Kwong, Gabriel A
Published in Science translational medicine (20.10.2021)
Published in Science translational medicine (20.10.2021)
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Journal Article
Aldehyde Dehydrogenase 2 in Cardiac Protection: A New Therapeutic Target?
Budas, Grant R, Disatnik, Marie-Hélène, Mochly-Rosen, Daria
Published in Trends in cardiovascular medicine (01.07.2009)
Published in Trends in cardiovascular medicine (01.07.2009)
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Journal Article
Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice
Sun, Xiaoyun, Budas, Grant R., Xu, Lijun, Barreto, George E., Mochly-Rosen, Daria, Giffard, Rona G.
Published in Journal of neuroscience research (01.06.2013)
Published in Journal of neuroscience research (01.06.2013)
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Journal Article
An apoptosis signal-regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia-reperfusion model
Gerczuk, Paul Z, Breckenridge, David G, Liles, John T, Budas, Grant R, Shryock, John C, Belardinelli, Luiz, Kloner, Robert A, Dai, Wangde
Published in Journal of cardiovascular pharmacology (01.09.2012)
Published in Journal of cardiovascular pharmacology (01.09.2012)
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