Total synthesis of bryostatin 3
Trost, Barry M, Wang, Youliang, Buckl, Andreas K, Huang, Zhongxing, Nguyen, Minh H, Kuzmina, Olesya
Published in Science (American Association for the Advancement of Science) (29.05.2020)
Published in Science (American Association for the Advancement of Science) (29.05.2020)
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Spirocyclic Oxetanes: Synthesis and Properties
Wuitschik, Georg, Rogers-Evans, Mark, Buckl, Andreas, Bernasconi, Maurizio, Märki, Moritz, Godel, Thierry, Fischer, Holger, Wagner, Björn, Parrilla, Isabelle, Schuler, Franz, Schneider, Josef, Alker, André, Schweizer, W. Bernd, Müller, Klaus, Carreira, Erick M.
Published in Angewandte Chemie (International ed.) (02.06.2008)
Published in Angewandte Chemie (International ed.) (02.06.2008)
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Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction
Buckl, Andreas, Quintana, Elsa, Lee, Grace J., Shifrin, Nataliya, Zhong, Mengqi, Garrenton, Lindsay S., Montgomery, David C., Stahlhut, Carlos, Zhao, Frances, Whalen, Dan M., Thompson, Severin K., Tambo-ong, Arlyn, Gliedt, Micah, Knox, John E., Cregg, James J., Aay, Naing, Choi, Jong, Nguyen, Bao, Tripathi, Atti, Zhao, Ruiping, Saldajeno-Concar, Mae, Marquez, Abby, Hsieh, Daphne, McDowell, Laura L., Koltun, Elena S., Bermingham, Alun, Wildes, David, Singh, Mallika, Wang, Zhengping, Hansen, Richard, Smith, Jan A., Gill, Adrian L.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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SHP2 25- 3- 256-3 3- 25-DISUBSTITUTED 3-METHYL PYRAZINES AND 256- TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS
BUCKL ANDREAS, KISS GERT, WON WALTER, KOLTUN ELENA S, SEMKO CHRISTOPHER, JOGALEKAR ASHUTOSH, AAY NAING, MELLEM KEVIN, GILL ADRIAN
Year of Publication 13.11.2023
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Year of Publication 13.11.2023
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RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 28.05.2024
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Year of Publication 28.05.2024
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암의 치료를 위한 RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, KNOX JOHN E
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
Patent
Abstract 4877: Allosteric inhibition of SHP2 variants containing cancer-associated activating mutations
Wildes, David, Aay, Naing, Buckl, Andreas, Hsieh, Daphne, Jogalekar, Ashutosh S., Kiss, Gert, Koltun, Elena S., Marquez, Abby, Mellem, Kevin T., Romero, Jason, Saldajeno-Concar, Mae, Schulze, Christopher J., Semko, Chris M., Won, Walter, Nichols, Robert J., Stahlhut, Carlos, Tzitzilonis, Christos, Gill, Adrian L., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity
Koltun, Elena S., Aay, Naing, Buckl, Andreas, Jogalekar, Ashutosh S., Kiss, Gert, Marquez, Abby, Mellem, Kevin T., Mordec, Kasia, Saldajeno-Concar, Mae, Semko, Chris M., Tibrewal, Nidhi, Tzitzilonis, Christos, Won, Walter, Smith, Jacqueline A., Wilson, Susan E., Nichols, Robert J., Wang, Zhengping, Wilds, David, Singh, Mallika, Gill, Adrian L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, WHALEN DANIEL M, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, AAY NAING, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
암의 치료에서 RAS 억제제로서 인돌 유도체
BUCKL ANDREAS, BURNETT G. LESLIE, RICE MEGHAN A, KOLTUN ELENA S, WILDES DAVID E, GILL ADRIAN L, LEE BIANCA JENNIFER, SINGH MALLIKA, CREGG JAMES, AAY NAING, LIU YANG, KNOX JOHN E
Year of Publication 16.05.2023
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Year of Publication 16.05.2023
Patent
Abstract 1598: RM-046, a first-in-class, mutant-selective, and oral KRASQ61H(ON) inhibitor that drives tumor regression in preclinical models and validates KRASQ61H as a therapeutic target
Yang, Yu C., Thompson, Severin, Montgomery, David, Quiñones, Antonio J., Wei, Xing, Madej, Benjamin, Tomlinson, Aidan, Shifrin, Nataliya T., McNamara, Alexander, Ahler, Ethan, McDowell, Laura L., Flagella, Michael, Setser, John, Chang, Stephanie, Wang, Zhican, Wang, Zhengping, Huang, Jun, Ballmer, Steve, li, Shaong, Buckl, Andreas, Koltun, Elena, Gill, Adrian, Jiang, Jingjing, Singh, Mallika, Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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이환식 헤테로아릴 화합물 및 이의 용도
BUCKL ANDREAS, TAMBO ONG ARLYN A, CREGG JAMES JOSEPH, KOLTUN ELENA S, THOMPSON SEVERIN, GLIEDT MICAH J, AAY NAING, GILL ADRIAN LIAM
Year of Publication 03.12.2021
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Year of Publication 03.12.2021
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이환식 헤테로사이클릴 화합물 및 이의 용도
BUCKL ANDREAS, TAMBO ONG ARLYN A, CREGG JAMES JOSEPH, KOLTUN ELENA S, THOMPSON SEVERIN, GLIEDT MICAH J, AAY NAING, GILL ADRIAN LIAM
Year of Publication 03.12.2021
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Year of Publication 03.12.2021
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RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, GLIEDT MICAH JAMES, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, THOMAS WILLIAM D, PITZEN JENNIFER, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
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이환식 헤테로아릴 화합물 및 이의 용도
BUCKL ANDREAS, TAMBO ONG ARLYN A, BURNETT G. LESLIE, THOMPSON SEVERIN, AAY NAING, LIU YANG, GILL ADRIAN LIAM, EDWARDS ANNE V, KOLTUN ELENA S, CREGG JAMES JOSEPH, GLIEDT MICAH J, THOMAS WILLIAM D, KNOX JOHN E
Year of Publication 18.07.2022
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Year of Publication 18.07.2022
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알로스테릭 SHP2 억제제로서의 피리딘 화합물
BUCKL ANDREAS, KISS GERT, KOLTUN ELENA S, SEMKO CHRISTOPHER, AAY NAING, MELLEM KEVIN, GILL ADRIAN
Year of Publication 30.09.2019
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Year of Publication 30.09.2019
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알로스테릭 SHP2 억제제로서의 피리딘, 피라진 및 트리아진 화합물
BUCKL ANDREAS, TZITZILONIS CHRISTOS, WON WALTER, KOLTUN ELENA S, CREGG JAMES JOSEPH, LI JIE JACK, AAY NAING, JOGALEKAR ASHUTOSH, MELLEM KEVIN, GILL ADRIAN LIAM
Year of Publication 17.06.2020
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Year of Publication 17.06.2020
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다른자리 입체성 SHP2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
BUCKL ANDREAS, KISS GERT, WON WALTER, KOLTUN ELENA S, SEMKO CHRISTOPHER, JOGALEKAR ASHUTOSH, AAY NAING, MELLEM KEVIN, GILL ADRIAN
Year of Publication 13.03.2019
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Year of Publication 13.03.2019
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