Improved Lipophilicity and Aqueous Solubility Prediction with Composite Graph Neural Networks
Wieder, Oliver, Kuenemann, Mélaine, Wieder, Marcus, Seidel, Thomas, Meyer, Christophe, Bryant, Sharon D, Langer, Thierry
Published in Molecules (Basel, Switzerland) (13.10.2021)
Published in Molecules (Basel, Switzerland) (13.10.2021)
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Journal Article
Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations
Tomašič, Tihomir, Durcik, Martina, Keegan, Bradley M, Skledar, Darja Gramec, Zajec, Živa, Blagg, Brian S J, Bryant, Sharon D
Published in International journal of molecular sciences (20.09.2020)
Published in International journal of molecular sciences (20.09.2020)
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Journal Article
Molecular Docking and 3D-Pharmacophore Modeling to Study the Interactions of Chalcone Derivatives with Estrogen Receptor Alpha
Muchtaridi, Muchtaridi, Syahidah, Hasna Nur, Subarnas, Anas, Yusuf, Muhammad, Bryant, Sharon D, Langer, Thierry
Published in Pharmaceuticals (Basel, Switzerland) (16.10.2017)
Published in Pharmaceuticals (Basel, Switzerland) (16.10.2017)
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Journal Article
Parameters for Irreversible Inactivation of Monoamine Oxidase
Ramsay, Rona R, Basile, Livia, Maniquet, Antonin, Hagenow, Stefanie, Pappalardo, Matteo, Saija, Maria Chiara, Bryant, Sharon D, Albreht, Alen, Guccione, Salvatore
Published in Molecules (Basel, Switzerland) (13.12.2020)
Published in Molecules (Basel, Switzerland) (13.12.2020)
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Journal Article
Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
Tomašič, Tihomir, Zubrienė, Asta, Skok, Žiga, Martini, Riccardo, Pajk, Stane, Sosič, Izidor, Ilaš, Janez, Matulis, Daumantas, Bryant, Sharon D.
Published in Pharmaceuticals (Basel, Switzerland) (10.08.2021)
Published in Pharmaceuticals (Basel, Switzerland) (10.08.2021)
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Journal Article
Dmt and opioid peptides: A potent alliance
Bryant, Sharon D., Jinsmaa, Yunden, Salvadori, Severo, Okada, Yoshio, Lazarus, Lawrence H.
Published in Biopolymers (2003)
Published in Biopolymers (2003)
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Journal Article
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach
Bampali, Konstantina, Koniuszewski, Filip, Vogel, Florian D., Fabjan, Jure, Andronis, Christos, Lekka, Eftychia, Virvillis, Vassilis, Seidel, Thomas, Delaunois, Annie, Royer, Leandro, Rolf, Michael G., Giuliano, Chiara, Traebert, Martin, Roussignol, Gautier, Fric-Bordat, Magali, Mazelin-Winum, Ludmilla, Bryant, Sharon D., Langer, Thierry, Ernst, Margot
Published in Cell biology and toxicology (01.12.2023)
Published in Cell biology and toxicology (01.12.2023)
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Journal Article
Cytotoxicity Of Chalcone Of Eugenia aquea Burm F. Leaves Against T47D Breast Cancer Cell Lines And Its Prediction As An Estrogen Receptor Antagonist Based On Pharmacophore-Molecular Dynamics Simulation
Muchtaridi, Muchtaridi, Yusuf, Muhammad, Syahidah, Hasna Nur, Subarnas, Anas, Zamri, Adel, Bryant, Sharon D, Langer, Thierry
Published in Advances and applications in bioinformatics and chemistry (01.11.2019)
Published in Advances and applications in bioinformatics and chemistry (01.11.2019)
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Journal Article
Shaping the future of safer innovative drugs in Europe
Mestres, Jordi, Bryant, Sharon D, Zamora, Ismael, Gasteiger, Johann
Published in Nature biotechnology (01.09.2011)
Published in Nature biotechnology (01.09.2011)
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Journal Article
Studies on the structure-activity relationship of 2', 6'-dimethyl-L-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3
FUJITA, Yoshio, TSUDA, Yuko, BRYANT, Sharon D, LAZARUS, Lawrence H, OKADA, Yoshio, MOTOYAMA, Takashi, LI, Tingyou, MIYAZAKI, Anna, YOKOI, Toshio, SASAKI, Yusuke, AMBO, Akihiro, NIIZUMA, Hideko, JINSMAA, Yunden
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands
Li, Tingyou, Shiotani, Kimitaka, Miyazaki, Anna, Tsuda, Yuko, Ambo, Akihiro, Sasaki, Yusuke, Jinsmaa, Yunden, Marczak, Ewa, Bryant, Sharon D, Lazarus, Lawrence H, Okada, Yoshio
Published in Journal of medicinal chemistry (14.06.2007)
Published in Journal of medicinal chemistry (14.06.2007)
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Journal Article
A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic
Salvadori, Severo, Trapella, Claudio, Fiorini, Stella, Negri, Lucia, Lattanzi, Roberta, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Balboni, Gianfranco
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Journal Article
Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties
Balboni, Gianfranco, Guerrini, Remo, Salvadori, Severo, Bianchi, Clementina, Rizzi, Daniela, Bryant, Sharon D, Lazarus, Lawrence H
Published in Journal of medicinal chemistry (31.01.2002)
Published in Journal of medicinal chemistry (31.01.2002)
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Journal Article
6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in δ- and μ-Selective Opioid Peptides
Vázquez, M. Eugenio, Blanco, Juan B, Salvadori, Severo, Trapella, Claudio, Argazzi, Roberto, Bryant, Sharon D, Jinsmaa, Yunden, Lazarus, Lawrence H, Negri, Lucia, Giannini, Elisa, Lattanzi, Roberta, Colucci, Mariantonella, Balboni, Gianfranco
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Journal Article
Studies on the Mechanism of 1,2-Dihydropyrazin-2-one Ring Formation from Dipeptidyl Chloromethyl Ketone and Its Chemical Properties: Immediate Deamination during Catalytic Hydrogenation
Miyazaki, Anna, Fujisawa, Yutaka, Shiotani, Kimitaka, Fujita, Yoshio, Li, Tingyou, Tsuda, Yuko, Yokoi, Toshio, Bryant, Sharon D., Lazarus, Lawrence H., Okada, Yoshio
Published in Chemical & Pharmaceutical Bulletin (2005)
Published in Chemical & Pharmaceutical Bulletin (2005)
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Journal Article
Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore
Balboni, Gianfranco, Onnis, Valentina, Congiu, Cenzo, Zotti, Margherita, Sasaki, Yusuke, Ambo, Akihiro, Bryant, Sharon D, Jinsmaa, Yunden, Lazarus, Lawrence H, Trapella, Claudio, Salvadori, Severo
Published in Journal of medicinal chemistry (07.09.2006)
Published in Journal of medicinal chemistry (07.09.2006)
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Journal Article
Development of Potent μ-Opioid Receptor Ligands Using Unique Tyrosine Analogues of Endomorphin-2
Li, Tingyou, Fujita, Yoshio, Tsuda, Yuko, Miyazaki, Anna, Ambo, Akihiro, Sasaki, Yusuke, Jinsmaa, Yunden, Bryant, Sharon D, Lazarus, Lawrence H, Okada, Yoshio
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Journal Article
Development of Potent Bifunctional Endomorphin-2 Analogues with Mixed μ-/δ-Opioid Agonist and δ-Opioid Antagonist Properties
Fujita, Yoshio, Tsuda, Yuko, Li, Tingyou, Motoyama, Takashi, Takahashi, Motohiro, Shimizu, Yoshiro, Yokoi, Toshio, Sasaki, Yusuke, Ambo, Akihiro, Kita, Atsuko, Jinsmaa, Yunden, Bryant, Sharon D, Lazarus, Lawrence H, Okada, Yoshio
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article
Differentiation of opioid receptor preference by [Dmt 1]endomorphin-2-mediated antinociception in the mouse
Jinsmaa, Yunden, Fujita, Yoshio, Shiotani, Kimitaka, Miyazaki, Anna, Li, Tingyou, Tsuda, Yuko, Okada, Yoshio, Ambo, Akihiro, Sasaki, Yusuke, Bryant, Sharon D., Lazarus, Lawrence H.
Published in European journal of pharmacology (10.02.2005)
Published in European journal of pharmacology (10.02.2005)
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