RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.
Published in Molecular cell (20.11.2014)
Published in Molecular cell (20.11.2014)
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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Machutta, Carl A, Kollmann, Christopher S, Lind, Kenneth E, Bai, Xiaopeng, Chan, Pan F, Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S, Barros-Aguirre, David, Bates, Robert H, Centrella, Paolo A, Chang, Sandy S, Chai, Jing, Choudhry, Anthony E, Coffin, Aaron, Davie, Christopher P, Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W, Fosbenner, David T, Gao, Enoch N, Graham, Taylor L, Graybill, Todd L, Ingraham, Karen, Johnson, Walter P, King, Bryan W, Kwiatkowski, Christopher R, Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O'Keefe, Heather P, O'Keeffe, Thomas, Pao, Christina, Phelps, Christopher B, Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S, Steiginga, Matt S, Sundersingh, Flora S, Sweitzer, Sharon M, Szewczuk, Lawrence M, Taylor, Amy, Toh, May Fern, Wang, Juan, Wang, Minghui, Wilkins, Devan J, Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P, Messer, Jeffrey A, Holmes, David, Arico-Muendel, Christopher C, Pope, Andrew J, Gross, Jeffrey W, Evindar, Ghotas
Published in Nature communications (17.07.2017)
Published in Nature communications (17.07.2017)
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Asymmetric Aldol Additions: Use of Titanium Tetrachloride and (−)-Sparteine for the Soft Enolization of N-Acyl Oxazolidinones, Oxazolidinethiones, and Thiazolidinethiones
Crimmins, Michael T, King, Bryan W, Tabet, Elie A, Chaudhary, Kleem
Published in Journal of organic chemistry (09.02.2001)
Published in Journal of organic chemistry (09.02.2001)
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors
Horton, John R., Pathuri, Sarath, Wong, Kristen, Ren, Ren, Rueda, Lourdes, Fosbenner, David T., Heerding, Dirk A., McCabe, Michael T., Pappalardi, Melissa B., Zhang, Xing, King, Bryan W., Cheng, Xiaodong
Published in Structure (London) (02.06.2022)
Published in Structure (London) (02.06.2022)
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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement
Barton, Linda S., Callahan, James F., Cantizani, Juan, Concha, Nestor O., Cotillo Torrejon, Ignacio, Goodwin, Nicole C., Joshi-Pangu, Amruta, Kiesow, Terry J., McAtee, Jeff J., Mellinger, Mark, Nixon, Christopher J., Padrón-Barthe, Laura, Patterson, Jaclyn R., Pearson, Neil D., Pouliot, Jeffrey J., Rendina, Alan R., Buitrago Santanilla, Alexander, Schneck, Jessica L., Sanz, Olalla, Thalji, Reema K., Ward, Paris, Williams, Shawn P., King, Bryan W.
Published in Bioorganic & medicinal chemistry (15.02.2024)
Published in Bioorganic & medicinal chemistry (15.02.2024)
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DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry
Xia, Bing, Franklin, G. Joseph, Lu, Xiaojie, Bedard, Katie L, Grady, LaShadric C, Summerfield, Jennifer D, Shi, Eric X, King, Bryan W, Lind, Kenneth E, Chiu, Cynthia, Watts, Eleanor, Bodmer, Vera, Bai, Xiaopeng, Marcaurelle, Lisa A
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity
Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda
Published in Bioorganic & medicinal chemistry (01.11.2015)
Published in Bioorganic & medicinal chemistry (01.11.2015)
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Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas
Published in Nature communications (13.07.2018)
Published in Nature communications (13.07.2018)
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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors
Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin
Published in Biochemistry (Easton) (09.08.2011)
Published in Biochemistry (Easton) (09.08.2011)
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Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Machutta, Carl A, Kollmann, Christopher S, Lind, Kenneth E, Bai, Xiaopeng, Chan, Pan F, Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S, Barros-Aguirre, David, Bates, Robert H, Centrella, Paolo A, Chang, Sandy S, Chai, Jing, Choudhry, Anthony E, Coffin, Aaron, Davie, Christopher P, Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W, Fosbenner, David T, Gao, Enoch N, Graham, Taylor L, Graybill, Todd L, Ingraham, Karen, Johnson, Walter P, King, Bryan W, Kwiatkowski, Christopher R, Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O'Keefe, Heather P, O'Keeffe, Thomas, Pao, Christina, Phelps, Christopher B, Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S, Steiginga, Matt S, Sundersingh, Flora S, Sweitzer, Sharon M, Szewczuk, Lawrence M, Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J, Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P, Messer, Jeffrey A, Holmes, David, Arico-Muendel, Christopher C, Pope, Andrew J, Gross, Jeffrey W, Evindar, Ghotas
Published in Nature communications (13.07.2018)
Published in Nature communications (13.07.2018)
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Synthesis and structure–activity relationship of a novel, non-hydroxamate series of TNF-α converting enzyme inhibitors
Gilmore, John L., King, Bryan W., Asakawa, Naoyuki, Harrison, Kimberly, Tebben, Andrew, Sheppeck, James E., Liu, Rui-Qin, Covington, Maryanne, Duan, James J.-W.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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