Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior
Ferris, Craig F., Lu, Shi-fang, Messenger, Tara, Guillon, Christophe D., Heindel, Ned, Miller, Marvin, Koppel, Gary, Robert Bruns, F., Simon, Neal G.
Published in Pharmacology, biochemistry and behavior (01.02.2006)
Published in Pharmacology, biochemistry and behavior (01.02.2006)
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Journal Article
Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor
Wang, Xushan, Hembre, Erik J, Goldsmith, Paul J, Beck, James P, Svensson, Kjell A, Willard, Francis S, Bruns, Robert F
Published in Molecular pharmacology (01.03.2023)
Published in Molecular pharmacology (01.03.2023)
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Journal Article
Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate
Castner, Stacy A., Zhang, Linli, Yang, Charles R., Hao, Junliang, Cramer, Jeffrey W., Wang, Xushan, Bruns, Robert F., Marston, Hugh, Svensson, Kjell A., Williams, Graham V.
Published in Psychopharmacology (01.05.2023)
Published in Psychopharmacology (01.05.2023)
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Journal Article
Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor
Wang, Xushan, Heinz, Beverly A, Qian, Yue-Wei, Carter, Joan H, Gadski, Robert A, Beavers, Lisa S, Little, Sheila P, Yang, Charles R, Beck, James P, Hao, Junliang, Schaus, John M, Svensson, Kjell A, Bruns, Robert F
Published in Molecular pharmacology (01.10.2018)
Published in Molecular pharmacology (01.10.2018)
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Journal Article
Synthesis and Pharmacological Characterization of 2‑(2,6-Dichlorophenyl)-1-((1S,3R)‑5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)‑yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
Hao, Junliang, Beck, James P, Schaus, John M, Krushinski, Joseph H, Chen, Qi, Beadle, Christopher D, Vidal, Paloma, Reinhard, Matthew R, Dressman, Bruce A, Massey, Steven M, Boulet, Serge L, Cohen, Michael P, Watson, Brian M, Tupper, David, Gardinier, Kevin M, Myers, Jason, Johansson, Anette M, Richardson, Jeffery, Richards, Daniel S, Hembre, Erik J, Remick, David M, Coates, David A, Bhardwaj, Rajni M, Diseroad, Benjamin A, Bender, David, Stephenson, Greg, Wolfangel, Craig D, Diaz, Nuria, Getman, Brian G, Wang, Xu-shan, Heinz, Beverly A, Cramer, Jeff W, Zhou, Xin, Maren, Deanna L, Falcone, Julie F, Wright, Rebecca A, Mitchell, Stephen N, Carter, Guy, Yang, Charles R, Bruns, Robert F, Svensson, Kjell A
Published in Journal of medicinal chemistry (10.10.2019)
Published in Journal of medicinal chemistry (10.10.2019)
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Journal Article
An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
Svensson, Kjell A, Heinz, Beverly A, Schaus, John M, Beck, James P, Hao, Junliang, Krushinski, Joseph H, Reinhard, Matthew R, Cohen, Michael P, Hellman, Sarah L, Getman, Brian G, Wang, Xushan, Menezes, Michelle M, Maren, Deanna L, Falcone, Julie F, Anderson, Wesley H, Wright, Rebecca A, Morin, S Michelle, Knopp, Kelly L, Adams, Benjamin L, Rogovoy, Borys, Okun, Ilya, Suter, Todd M, Statnick, Michael A, Gehlert, Donald R, Nelson, David L, Lucaites, Virginia L, Emkey, Renee, DeLapp, Neil W, Wiernicki, Todd R, Cramer, Jeffrey W, Yang, Charles R, Bruns, Robert F
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
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Journal Article
Potent and Selective 1,2,3-Trisubstituted Indole NPY Y-1 Antagonists
Hipskind, Philip A, Lobb, Karen L, Nixon, James A, Britton, Thomas C, Bruns, Robert F, Catlow, John, Dieckman-McGinty, Donna K, Gackenheimer, Susan L, Gitter, Bruce D, Iyengar, Smriti, Schober, Douglas A, Simmons, Rosa M. A, Swanson, Steve, Zarrinmayeh, Hamideh, Zimmerman, Dennis M, Gehlert, Donald R
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Journal Article
Azetidinones as vasopressin V1a antagonists
Guillon, Christophe D., Koppel, Gary A., Brownstein, Michael J., Chaney, Michael O., Ferris, Craig F., Lu, Shi-fang, Fabio, Karine M., Miller, Marvin J., Heindel, Ned D., Hunden, David C., Cooper, Robin D.G., Kaldor, Stephen W., Skelton, Jeffrey J., Dressman, Bruce A., Clay, Michael P., Steinberg, Mitchell I., Bruns, Robert F., Simon, Neal G.
Published in Bioorganic & medicinal chemistry (01.03.2007)
Published in Bioorganic & medicinal chemistry (01.03.2007)
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Journal Article
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
Zarrinmayeh, Hamideh, Nunes, Anne M, Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Schober, Douglas A, Gackenheimer, Susan L, Bruns, Robert F, Hipskind, Philip A, Britton, Thomas C, Cantrell, Buddy E, Gehlert, Donald R
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Inhibition of protein kinase C by calphostin C is light-dependent
Bruns, Robert F., Miller, F.Dean, Merriman, Ronald L., Howbert, J.Jeffry, Heath, William F., Kobayashi, Eiji, Takahashi, Isami, Tamaoki, Tatsuya, Nakano, Hirofumi
Published in Biochemical and biophysical research communications (15.04.1991)
Published in Biochemical and biophysical research communications (15.04.1991)
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Journal Article
Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application
Hamilton, Harriet W, Ortwine, Daniel F, Worth, Donald F, Badger, Edward W, Bristol, James A, Bruns, Robert F, Haleen, Stephen J, Steffen, Robert P
Published in Journal of medicinal chemistry (01.08.1985)
Published in Journal of medicinal chemistry (01.08.1985)
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Journal Article
A rapid filtration assay for soluble receptors using polyethylenimine-treated filters
Bruns, Robert F., Lawson-Wendling, Karen, Pugsley, Thomas A.
Published in Analytical biochemistry (01.07.1983)
Published in Analytical biochemistry (01.07.1983)
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Journal Article
3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists
Hipskind, Philip A, Howbert, J. Jeffry, Bruns, Robert F, Cho, Steven S. Y, Crowell, Thomas A, Foreman, Mark M, Gehlert, Donald R, Iyengar, Smriti, Johnson, Kirk W, Krushinski, Joseph H, Li, Dominic L, Lobb, Karen L, Mason, Norman R, Muehl, Brian S, Nixon, James A, Phebus, Lee A, Regoli, Domenico, Simmons, Rosa M, Threlkeld, Penny G, Waters, Diane C, Gitter, Bruce D
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes
Bruns, R F, Fergus, J H, Badger, E W, Bristol, J A, Santay, L A, Hartman, J D, Hays, S J, Huang, C C
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.01.1987)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.01.1987)
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