Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose
Ferrara, Claudia, Grau, Sandra, Jäger, Christiane, Sondermann, Peter, Brünker, Peter, Waldhauer, Inja, Hennig, Michael, Ruf, Armin, Rufer, Arne Christian, Stihle, Martine, Umaña, Pablo, Benz, Jörg
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2011)
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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity
Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo
Published in Blood (03.06.2010)
Published in Blood (03.06.2010)
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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity
Sum, Eva, Rapp, Moritz, Fröbel, Philipp, Le Clech, Marine, Dürr, Harald, Giusti, Anna Maria, Perro, Mario, Speziale, Dario, Kunz, Leo, Menietti, Elena, Brünker, Peter, Hopfer, Ulrike, Lechmann, Martin, Sobieniecki, Andrzej, Appelt, Birte, Adelfio, Roberto, Nicolini, Valeria, Freimoser-Grundschober, Anne, Jordaan, Whitney, Labiano, Sara, Weber, Felix, Emrich, Thomas, Christen, François, Essig, Birgit, Romero, Pedro, Trumpfheller, Christine, Umaña, Pablo
Published in Clinical cancer research (15.07.2021)
Published in Clinical cancer research (15.07.2021)
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Adaptor Anti-P329G CAR T Cells for Modular Targeting of AML
Stock, Sophia, Strzalkowski, Thaddaeus, Gottschlich, Adrian, Rohrbacher, Lisa, Fertig, Luisa, Menkhoff, Vivien D., Surowka, Marlena, Bruenker, Peter, Darowski, Diana, Endres, Stefan, von Bergwelt-Baildon, Michael, Subklewe, Marion, Klein, Christian, Kobold, Sebastian
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F, Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E, Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils
Weber, Felix, Breustedt, Daniel, Schlicht, Sonja, Meyer, Claas A., Niewoehner, Jens, Ebeling, Martin, Freskgard, Per-Ola, Bruenker, Peter, Singer, Thomas, Reth, Michael, Iglesias, Antonio
Published in Pharmaceutical research (01.09.2018)
Published in Pharmaceutical research (01.09.2018)
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P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation
Darowski, Diana, Jost, Christian, Stubenrauch, Kay, Wessels, Uwe, Benz, Jörg, Ehler, Andreas, Freimoser-Grundschober, Anne, Brünker, Peter, Mössner, Ekkehard, Umaña, Pablo, Kobold, Sebastian, Klein, Christian
Published in Protein engineering, design and selection (31.12.2019)
Published in Protein engineering, design and selection (31.12.2019)
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Journal Article
프로테아제 활성화된 T 세포 이중특이성 항체
BRUENKER PETER, CARPY GUTIERREZ CIRLOS ALEJANDRO, HOFER THOMAS, KLEIN CHRISTIAN, GEIGER MARTINA, NEUMANN CHRISTIANE, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 22.02.2023
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Year of Publication 22.02.2023
Patent
Abstract C125: Preclinical pharmacodynamic biomarker and combination strategy of RG7386, a novel FAP-DR5 bispecific antibody for targeting solid tumors
Friess, Thomas, Broeske, Ann-Marie, Lechner, Stefanie, Abraham, Esther, Hoelzlwimmer, Gabriele, Sade, Hadassa, Bruenker, Peter, Krieter, Oliver
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Abstract 952: Induction of avidity-driven hyperclustering of DR5 by a new FAP-DR5 bispecific antibody (RG7386) leads to strong anti-tumor efficacy
Friess, Thomas, Lechner, Stefanie, Abraham, Esther, Broeske, Ann-Marie, Bader, Sabine, Roller, Andreas, Majety, Meher, Wartha, Katharina, Vega-Harring, Suzana, Sade, Hadassah, Krieter, Oliver, Bruenker, Peter
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 4573: A novel bispecific Fap-Dr5 antibody inducing potent and tumor-specific death receptor 5 (Dr5) activation by fibroblast activation protein (Fap)-dependent crosslinking
Wartha, Katharina, Weiser, Barbara, Friess, Thomas, Majety, Meher, Runza, Valeria, Herting, Frank, Weber, Thomas, Scheuer, Werner, Harring, Suzana Vega, Sade, Hadassah, Niu, Huifeng, Bruenker, Peter
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 2481: CEA TCB, a novel T-cell bispecific antibody with potent in vitro and in vivo antitumor activity against solid tumors
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
항-FAP 클론 212를 포함하는 이중특이적 항원 결합 분자
BRUENKER PETER, ZIELONKA JOERG, LE CLECH MARINE, DUERR HARALD, KLEIN CHRISTIAN, TRUMPELLER CHRISTINE, UMANA PABLO, RAPP MORITZ, BUJOTZEK ALEXANDER
Year of Publication 11.06.2021
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Year of Publication 11.06.2021
Patent
ITOC2 – 037. CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in European journal of cancer (1990) (01.03.2015)
Published in European journal of cancer (1990) (01.03.2015)
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Journal Article
A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys
Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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