Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria
Lai, Chengjung, Pursell, Natalie, Gierut, Jessica, Saxena, Utsav, Zhou, Wei, Dills, Michael, Diwanji, Rohan, Dutta, Chaitali, Koser, Martin, Nazef, Naim, Storr, Rachel, Kim, Boyoung, Martin-Higueras, Cristina, Salido, Eduardo, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Brown, Bob D.
Published in Molecular therapy (01.08.2018)
Published in Molecular therapy (01.08.2018)
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Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
Ariceta, Gema, Barrios, Kelly, Brown, Bob D., Hoppe, Bernd, Rosskamp, Ralf, Langman, Craig B.
Published in Kidney international reports (01.04.2021)
Published in Kidney international reports (01.04.2021)
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RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade
Ganesh, Shanthi, Shui, Xue, Craig, Kevin P., Park, Jihye, Wang, Weimin, Brown, Bob D., Abrams, Marc T.
Published in Molecular therapy (07.11.2018)
Published in Molecular therapy (07.11.2018)
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Bcl-2 and Glutathione Depletion Sensitizes B16 Melanoma to Combination Therapy and Eliminates Metastatic Disease
MENA, Salvador, BENLLOCH, Maria, ORTEGA, Angel, CARRETERO, Julian, OBRADOR, Elena, ASENSI, Miguel, PETSCHEN, Ignacio, BROWN, Bob D, ESTRELA, José M
Published in Clinical cancer research (01.05.2007)
Published in Clinical cancer research (01.05.2007)
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Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria
Forbes, Thomas A., Brown, Bob D., Lai, Chengjung
Published in British journal of clinical pharmacology (01.06.2022)
Published in British journal of clinical pharmacology (01.06.2022)
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Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts
Anai, Satoshi, Goodison, Steve, Shiverick, Kathleen, Hirao, Yoshihiko, Brown, Bob D, Rosser, Charles J
Published in Molecular cancer therapeutics (01.01.2007)
Published in Molecular cancer therapeutics (01.01.2007)
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bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
Jansen, B, Schlagbauer-Wadl, H, Brown, B D, Bryan, R N, van Elsas, A, Müller, M, Wolff, K, Eichler, H G, Pehamberger, H
Published in Nature medicine (01.02.1998)
Published in Nature medicine (01.02.1998)
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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1
Mena, Salvador, Rodriguez, María L, Ortega, Angel, Priego, Sonia, Obrador, Elena, Asensi, Miguel, Petschen, Ignacio, Cerdá, Miguel, Brown, Bob D, Estrela, José M
Published in Journal of translational medicine (10.01.2012)
Published in Journal of translational medicine (10.01.2012)
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Downregulation of BCL-2 Induces Downregulation of Carbonic Anhydrase IX, Vascular Endothelial Growth Factor, and pAkt and Induces Radiation Sensitization
Anai, Satoshi, Shiverick, Kathleen, Medrano, Theresa, Nakamura, Kogenta, Goodison, Steve, Brown, Bob D, Rosser, Charles J
Published in Urology (Ridgewood, N.J.) (01.10.2007)
Published in Urology (Ridgewood, N.J.) (01.10.2007)
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First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection
Gane, Edward J., Kim, Won, Lim, Tien Huey, Tangkijvanich, Pisit, Yoon, Jung-Hwan, Sievert, William, Sukeepaisarnjaroen, Wattana, Thompson, Alexander J., Pavlovic, Vedran, Surujbally, Bernadette, Wat, Cynthia, Brown, Bob D., Achneck, Hardean E., Yuen, Man-Fung
Published in Journal of hepatology (01.11.2023)
Published in Journal of hepatology (01.11.2023)
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RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors
Ganesh, Shanthi, Kim, Min Ju, Lee, Jenny, Feng, Xudong, Ule, Krisjanis, Mahan, Amy, Krishnan, Harini Sivagurunatha, Wang, Zhe, Anzahaee, Maryam Yahyaee, Singhal, Garima, Korboukh, Ilia, Lockridge, Jennifer A., Sanftner, Laura, Rijnbrand, Rene, Abrams, Marc, Brown, Bob D.
Published in Molecular therapy (05.06.2024)
Published in Molecular therapy (05.06.2024)
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Quantitative analysis of dicer substrate oligonucleotides in mouse liver by ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
Jiao, Kaisheng, Rashid, Aftab, Basu, Sujit K, Zhu, Shuhao, Brown, Bob D, Guerciolini, Roberto, Fambrough, Douglas M
Published in Assay and drug development technologies (01.06.2012)
Published in Assay and drug development technologies (01.06.2012)
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Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1
Dutta, Chaitali, Avitahl-Curtis, Nicole, Pursell, Natalie, Larsson Cohen, Marita, Holmes, Benjamin, Diwanji, Rohan, Zhou, Wei, Apponi, Luciano, Koser, Martin, Ying, Bo, Chen, Dongyu, Shui, Xue, Saxena, Utsav, Cyr, Wendy A, Shah, Anee, Nazef, Naim, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Salido, Eduardo, Brown, Bob D, Lai, Chengjung
Published in Molecular therapy (01.04.2016)
Published in Molecular therapy (01.04.2016)
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Bcl-2 Protein in 518A2 Melanoma Cells In vivo and In vitro
BENIMETSKAYA, Luba, AYYANAR, Kanyalakshmi, MCMICKEN, Harilyn, YIN CHEN, STEIN, C. A, KORNBLUM, Noah, CASTANOTTO, Daniela, ROSSI, John, SIJIAN WU, LAI, Johnathan, BROWN, Bob D, POPOVA, Natalia, MILLER, Paul
Published in Clinical cancer research (15.08.2006)
Published in Clinical cancer research (15.08.2006)
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Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases
Pursell, Natalie, Gierut, Jessica, Zhou, Wei, Dills, Michael, Diwanji, Rohan, Gjorgjieva, Monika, Saxena, Utsav, Yang, Jr-Shiuan, Shah, Anee, Venkat, Nandini, Storr, Rachel, Kim, Boyoung, Wang, Weimin, Abrams, Marc, Raffin, Margaux, Mithieux, Gilles, Rajas, Fabienne, Dudek, Henryk, Brown, Bob D., Lai, Chengjung
Published in Molecular therapy (05.07.2018)
Published in Molecular therapy (05.07.2018)
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Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin
Ganesh, Shanthi, Koser, Martin L, Cyr, Wendy A, Chopda, Girish R, Tao, Junyan, Shui, Xue, Ying, Bo, Chen, Dongyu, Pandya, Purva, Chipumuro, Edmond, Siddiquee, Zakir, Craig, Kevin, Lai, Chengjung, Dudek, Henryk, Monga, Satdarshan P, Wang, Weimin, Brown, Bob D, Abrams, Marc T
Published in Molecular cancer therapeutics (01.09.2016)
Published in Molecular cancer therapeutics (01.09.2016)
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Irradiation of Human Prostate Cancer Cells Increases Uptake of Antisense Oligodeoxynucleotide
Anai, Satoshi, M.D, Brown, Bob D., M.D., Ph.D, Nakamura, Kogenta, M.D., Ph.D, Goodison, Steve, Ph.D, Hirao, Yoshihiko, M.D, Rosser, Charles J., M.D
Published in International journal of radiation oncology, biology, physics (15.07.2007)
Published in International journal of radiation oncology, biology, physics (15.07.2007)
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β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models
Ganesh, Shanthi, Shui, Xue, Craig, Kevin P, Koser, Martin L, Chopda, Girish R, Cyr, Wendy A, Lai, Chengjung, Dudek, Henryk, Wang, Weimin, Brown, Bob D, Abrams, Marc T
Published in Molecular cancer therapeutics (01.02.2018)
Published in Molecular cancer therapeutics (01.02.2018)
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Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo
Dudek, Henryk, Wong, Darren H, Arvan, Rokhand, Shah, Anee, Wortham, Kathleen, Ying, Bo, Diwanji, Rohan, Zhou, Wei, Holmes, Benjamin, Yang, Hailin, Cyr, Wendy A, Zhou, Yi, Shah, Aalok, Farkiwala, Ruchir, Lee, Michael, Li, Yiting, Rettig, Garrett R, Collingwood, Michael A, Basu, Sujit K, Behlke, Mark A, Brown, Bob D
Published in Molecular therapy (01.01.2014)
Published in Molecular therapy (01.01.2014)
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