Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
Brown, Jacquelyn A, Pensabene, Virginia, Markov, Dmitry A, Allwardt, Vanessa, Neely, M Diana, Shi, Mingjian, Britt, Clayton M, Hoilett, Orlando S, Yang, Qing, Brewer, Bryson M, Samson, Philip C, McCawley, Lisa J, May, James M, Webb, Donna J, Li, Deyu, Bowman, Aaron B, Reiserer, Ronald S, Wikswo, John P
Published in Biomicrofluidics (01.09.2015)
Published in Biomicrofluidics (01.09.2015)
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Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Brown, Jacquelyn A, Codreanu, Simona G, Shi, Mingjian, Sherrod, Stacy D, Markov, Dmitry A, Neely, M Diana, Britt, Clayton M, Hoilett, Orlando S, Reiserer, Ronald S, Samson, Philip C, McCawley, Lisa J, Webb, Donna J, Bowman, Aaron B, McLean, John A, Wikswo, John P
Published in Journal of neuroinflammation (12.12.2016)
Published in Journal of neuroinflammation (12.12.2016)
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Journal Article
Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus
Boghdeh, Niloufar A, Risner, Kenneth H, Barrera, Michael D, Britt, Clayton M, Schaffer, David K, Alem, Farhang, Brown, Jacquelyn A, Wikswo, John P, Narayanan, Aarthi
Published in Viruses (01.12.2022)
Published in Viruses (01.12.2022)
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Journal Article
Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice
Brown, Jacquelyn A., Emnett, Ryan J., White, Crystal R., Yuede, Carla M., Conyers, Sara B., O'Malley, Karen L., Wozniak, David F., Gutmann, David H.
Published in Human molecular genetics (15.11.2010)
Published in Human molecular genetics (15.11.2010)
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Journal Article
Advances in blood-brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure
Brown, Jacquelyn A, Faley, Shannon L, Shi, Yajuan, Hillgren, Kathleen M, Sawada, Geri A, Baker, Thomas K, Wikswo, John P, Lippmann, Ethan S
Published in Fluids and barriers of the CNS (03.06.2020)
Published in Fluids and barriers of the CNS (03.06.2020)
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Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit
Brown, Jacquelyn A, Faley, Shannon L, Judge, Monika, Ward, Patricia, Ihrie, Rebecca A, Carson, Robert, Armstrong, Laura, Sahin, Mustafa, Wikswo, John P, Ess, Kevin C, Neely, M Diana
Published in Journal of neurodevelopmental disorders (23.05.2024)
Published in Journal of neurodevelopmental disorders (23.05.2024)
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Journal Article
Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy
Xia, Mengying, Varmazyad, Mahboubeh, Pla-Palacín, Iris, Gavlock, Dillon C, DeBiasio, Richard, LaRocca, Gregory, Reese, Celeste, Florentino, Rodrigo M, Faccioli, Lanuza A P, Brown, Jacquelyn A, Vernetti, Lawrence A, Schurdak, Mark, Stern, Andrew M, Gough, Albert, Behari, Jaideep, Soto-Gutierrez, Alejandro, Taylor, D Lansing, Miedel, Mark T
Published in Frontiers in cell and developmental biology (11.09.2024)
Published in Frontiers in cell and developmental biology (11.09.2024)
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Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice
Wozniak, David F, Diggs-Andrews, Kelly A, Conyers, Sara, Yuede, Carla M, Dearborn, Joshua T, Brown, Jacquelyn A, Tokuda, Kazuhiro, Izumi, Yukitoshi, Zorumski, Charles F, Gutmann, David H
Published in PloS one (10.06.2013)
Published in PloS one (10.06.2013)
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Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
Vernetti, Lawrence, Gough, Albert, Baetz, Nicholas, Blutt, Sarah, Broughman, James R, Brown, Jacquelyn A, Foulke-Abel, Jennifer, Hasan, Nesrin, In, Julie, Kelly, Edward, Kovbasnjuk, Olga, Repper, Jonathan, Senutovitch, Nina, Stabb, Janet, Yeung, Catherine, Zachos, Nick C, Donowitz, Mark, Estes, Mary, Himmelfarb, Jonathan, Truskey, George, Wikswo, John P, Taylor, D Lansing
Published in Scientific reports (08.02.2017)
Published in Scientific reports (08.02.2017)
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Journal Article
The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models
Hawkins, Kyle G., Casolaro, Caleb, Brown, Jacquelyn A., Edwards, David A., Wikswo, John P.
Published in Clinical pharmacology and therapeutics (01.11.2020)
Published in Clinical pharmacology and therapeutics (01.11.2020)
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Journal Article
Predicting susceptibility to SARS‐CoV‐2 infection based on structural differences in ACE2 across species
Alexander, Matthew R., Schoeder, Clara T., Brown, Jacquelyn A., Smart, Charles D., Moth, Chris, Wikswo, John P., Capra, John A., Meiler, Jens, Chen, Wenbiao, Madhur, Meena S.
Published in The FASEB Journal (01.12.2020)
Published in The FASEB Journal (01.12.2020)
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Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assays
Faley, Shannon L, Boghdeh, Niloufar A, Schaffer, David K, Spivey, Eric C, Alem, Farhang, Narayanan, Aarthi, Wikswo, John P, Brown, Jacquelyn A
Published in Lab on a chip (12.03.2024)
Published in Lab on a chip (12.03.2024)
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Journal Article
Coordinated Messenger RNA/MicroRNA Changes in Fibroblasts of Patients with Major Depression
Garbett, Krassimira A, Vereczkei, Andrea, Kálmán, Sára, Brown, Jacquelyn A, Taylor, Warren D, Faludi, Gábor, Korade, Željka, Shelton, Richard C, Mirnics, Károly
Published in Biological psychiatry (1969) (01.02.2015)
Published in Biological psychiatry (1969) (01.02.2015)
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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
Saul, Sirle, Karim, Marwah, Ghita, Luca, Huang, Pei-Tzu, Chiu, Winston, Durán, Verónica, Lo, Chieh-Wen, Kumar, Sathish, Bhalla, Nishank, Leyssen, Pieter, Alem, Farhang, Boghdeh, Niloufar A, Tran, Do Hn, Cohen, Courtney A, Brown, Jacquelyn A, Huie, Kathleen E, Tindle, Courtney, Sibai, Mamdouh, Ye, Chengjin, Khalil, Ahmed Magdy, Chiem, Kevin, Martinez-Sobrido, Luis, Dye, John M, Pinsky, Benjamin A, Ghosh, Pradipta, Das, Soumita, Solow-Cordero, David E, Jin, Jing, Wikswo, John P, Jochmans, Dirk, Neyts, Johan, De Jonghe, Steven, Narayanan, Aarthi, Einav, Shirit
Published in The Journal of clinical investigation (01.10.2023)
Published in The Journal of clinical investigation (01.10.2023)
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Journal Article
Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
Vernetti, Lawrence, Gough, Albert, Baetz, Nicholas, Blutt, Sarah, Broughman, James R, Brown, Jacquelyn A, Foulke-Abel, Jennifer, Hasan, Nesrin, In, Julie, Kelly, Edward, Kovbasnjuk, Olga, Repper, Jonathan, Senutovitch, Nina, Stabb, Janet, Yeung, Catherine, Zachos, Nick C, Donowitz, Mark, Estes, Mary, Himmelfarb, Jonathan, Truskey, George, Wikswo, John P, Taylor, D Lansing
Published in Scientific reports (16.03.2017)
Published in Scientific reports (16.03.2017)
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