Search Results - "BROWN, Dean" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

by Brown, Dean G, Boström, Jonas
Published in Journal of medicinal chemistry (26.05.2016)

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Journal Article

An Analysis of Successful Hit-to-Clinical Candidate Pairs

An Analysis of Successful Hit-to-Clinical Candidate Pairs

by Brown, Dean G.
Published in Journal of medicinal chemistry (08.06.2023)

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Journal Article

A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions

A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions

by Brown, Dean G, Wobst, Heike J
Published in Journal of medicinal chemistry (11.03.2021)

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Journal Article

A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs

A Drug Discovery Perspective on FDA Expedited Development and Incentive Programs

by Brown, Dean G.
Published in Journal of medicinal chemistry (08.02.2024)

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Journal Article

Adapting to the Changing Landscape of Biotech-Driven Drug Discovery

Adapting to the Changing Landscape of Biotech-Driven Drug Discovery

by Brown, Dean G.
Published in Journal of medicinal chemistry (14.12.2023)

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Journal Article

Correction to “An Analysis of Successful Hit-to-Clinical Candidate Pairs”

Correction to “An Analysis of Successful Hit-to-Clinical Candidate Pairs”

by Brown, Dean G.
Published in Journal of medicinal chemistry (13.07.2023)

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Journal Article

Expanding the medicinal chemistry synthetic toolbox

Expanding the medicinal chemistry synthetic toolbox

by Boström, Jonas, Brown, Dean G, Young, Robert J, Keserü, György M
Published in Nature reviews. Drug discovery (01.10.2018)

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Journal Article

Where Do Recent Small Molecule Clinical Development Candidates Come From?

Where Do Recent Small Molecule Clinical Development Candidates Come From?

by Brown, Dean G, Boström, Jonas
Published in Journal of medicinal chemistry (08.11.2018)

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Journal Article

ESKAPEing the labyrinth of antibacterial discovery

ESKAPEing the labyrinth of antibacterial discovery

by Tommasi, Ruben, Brown, Dean G, Walkup, Grant K, Manchester, John I, Miller, Alita A
Published in Nature reviews. Drug discovery (01.08.2015)

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Journal Article Book Review

New natural products as new leads for antibacterial drug discovery

New natural products as new leads for antibacterial drug discovery

by Brown, Dean G., Lister, Troy, May-Dracka, Tricia L.
Published in Bioorganic & medicinal chemistry letters (15.01.2014)

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Journal Article

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

by Brown, Dean G, May-Dracka, Tricia L, Gagnon, Moriah M, Tommasi, Ruben
Published in Journal of medicinal chemistry (11.12.2014)

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Journal Article

Drug discovery strategies to outer membrane targets in Gram-negative pathogens

Drug discovery strategies to outer membrane targets in Gram-negative pathogens

by Brown, Dean G.
Published in Bioorganic & medicinal chemistry (15.12.2016)

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Journal Article

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

by Brown, Dean G., Shorter, James, Wobst, Heike J.
Published in Bioorganic & medicinal chemistry letters (15.02.2020)

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Journal Article

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

by Morgan, Paul, Brown, Dean G, Lennard, Simon, Anderton, Mark J, Barrett, J Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E, Matcham, James, Mettetal, Jerome, Nicholls, David J, Platz, Stefan, Rees, Steve, Snowden, Michael A, Pangalos, Menelas N
Published in Nature reviews. Drug discovery (01.03.2018)

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Journal Article

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

by Silva, M Catarina, Nandi, Ghata A, Tentarelli, Sharon, Gurrell, Ian K, Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C, Brown, Dean G, Brandon, Nicholas J, Haggarty, Stephen J
Published in Nature communications (26.06.2020)

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Journal Article

Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases

Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases

by Brown, Dean G., Wobst, Heike J.
Published in Bioorganic & medicinal chemistry (15.02.2023)

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Journal Article

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

by Wobst, Heike J., Mack, Korrie L., Brown, Dean G., Brandon, Nicholas J., Shorter, James
Published in Medicinal research reviews (01.07.2020)

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Journal Article

Some Observations and Guidance on Perspectives in the Journal of Medicinal Chemistry

Some Observations and Guidance on Perspectives in the Journal of Medicinal Chemistry

by Brown, Dean G, Meanwell, Nicholas A, Lindsley, Craig W
Published in Journal of medicinal chemistry (23.02.2023)

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Journal Article

A survey of the clinical pipeline in neuroscience

A survey of the clinical pipeline in neuroscience

by Brown, Dean G., Wobst, Heike J.
Published in Bioorganic & medicinal chemistry letters (15.01.2022)

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Journal Article

Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies

by Brown, Dean G, Smith, Graham F, Wobst, Heike J
Published in Journal of medicinal chemistry (25.06.2020)

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Journal Article

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