Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant
Huang, Wei-Sheng, Metcalf, Chester A, Sundaramoorthi, Raji, Wang, Yihan, Zou, Dong, Thomas, R. Mathew, Zhu, Xiaotian, Cai, Lisi, Wen, David, Liu, Shuangying, Romero, Jan, Qi, Jiwei, Chen, Ingrid, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Zhou, Tianjun, Commodore, Lois, Narasimhan, Narayana I, Mohemmad, Qurish K, Iuliucci, John, Rivera, Victor M, Dalgarno, David C, Sawyer, Tomi K, Clackson, Tim, Shakespeare, William C
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE
STRESSER, David M, BROUDY, Marc I, PATTEN, Christopher J, DEHAL, Shangara S, CRESPI, Charles L, THUY HO, CARGILL, Catherine E, BLANCHARD, Andrew P, SHARMA, Raman, DANDENEAU, Andre A, GOODWIN, Joseph J, TURNER, Stephanie D, ERVE, John C. L
Published in Drug metabolism and disposition (01.01.2004)
Published in Drug metabolism and disposition (01.01.2004)
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9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation
Huang, Wei-Sheng, Zhu, Xiaotian, Wang, Yihan, Azam, Mohammad, Wen, David, Sundaramoorthi, Raji, Thomas, R. Mathew, Liu, Shuangying, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Daley, George Q, Iuliucci, John, Dalgarno, David C, Clackson, Tim, Sawyer, Tomi K, Shakespeare, William C
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant
Thomas, Mathew, Huang, Wei-Sheng, Wen, David, Zhu, Xiaotian, Wang, Yihan, Metcalf, Chester A., Liu, Shuangying, Chen, Ingrid, Romero, Jan, Zou, Dong, Sundaramoorthi, Raji, Li, Feng, Qi, Jiwei, Cai, Lisi, Zhou, Tianjun, Commodore, Lois, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T., Broudy, Marc I., Russian, Karin, Iuliucci, John, Rivera, Victor M., Sawyer, Tomi K., Dalgarno, David C., Clackson, Tim, Shakespeare, William C.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible
Stresser, David M, Broudy, Marc I, Ho, Thuy, Cargill, Catherine E, Blanchard, Andrew P, Sharma, Raman, Dandeneau, Andre A, Goodwin, Joseph J, Turner, Stephanie D, Erve, John C L, Patten, Christopher J, Dehal, Shangara S, Crespi, Charles L
Published in Drug metabolism and disposition (01.01.2004)
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Published in Drug metabolism and disposition (01.01.2004)
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Quantification of 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol in Urine Using Brominated 9-Carboxy-11-nor-Δ9-tetrahydrocannabinol as the Internal Standard and High-Performance Liquid Chromatography with Electrochemical Detection
Fisher, Daniel H., Broudy, Marc I., Fisher, L. Megan
Published in Biomedical chromatography (01.07.1996)
Published in Biomedical chromatography (01.07.1996)
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