In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
Barrow, JC, Nantermet, PG, Selnick, HG, Glass, KL, Rittle, KE, Gilbert, KF, Steele, TG, Homnick, CF, Freidinger, RM, Ransom, RW, Kling, P, Reiss, D, Broten, TP, Schorn, TW, Chang, RSL, O'Malley, SS, Olah, TV, Ellis, JD, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones
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4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)-[[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A potent and selective alpha(1b) adrenergic receptor antagonist
Patane, MA, Scott, AL, Broten, TP, Chang, RSL, Ransom, RW, DiSalvo, J, Forray, C, Bock, MG
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety
Dhar, TGM, Nagarathnam, D, Marzabadi, MR, Lagu, B, Wong, WC, Chiu, G, Tyagarajan, S, Miao, SW, Zhang, FQ, Sun, WY, Tian, D, Shen, QR, Zhang, J, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Schorn, TW, Chen, TB, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Zhang, KY, Gilbert, J, Pettibone, DJ, Patane, MA, Bock, MG, Freidinger, RM, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)
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Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation
Broten, T P, Miyashiro, J K, Moncada, S, Feigl, E O
Published in The American journal of physiology (01.05.1992)
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Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists
DiPardo, R M, Patane, M A, Newton, R C, Price, R, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Freidinger, R M, Bock, M G
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series
Wong, WC, Sun, WY, Lagu, B, Tian, D, Marzabadi, MR, Zhang, FQ, Nagarathnam, D, Miao, SW, Wetzel, JM, Peng, J, Forray, C, Chang, RSL, Chen, TB, Ransom, R, O'Malley, S, Broten, TP, Kling, P, Vyas, KP, Zhang, KY, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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De novo design of a novel oxazolidinone analogue as a potent and selective alpha(1A) adrenergic receptor antagonist with high oral bioavailability
Lagu, B, Tian, D, Jeon, Y, Li, C, Wetzel, JM, Nagarathnam, D, Shen, QR, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Chan, TB, O'Malley, SS, Schorn, TW, Rodrigues, AD, Kassahun, K, Pettibone, DJ, Freidinger, R, Gluchowski, C
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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A HIGHLY POTENT, ORALLY-ACTIVE IMIDAZO[4,5-B]PYRIDINE BIPHENYLACYLSULFONAMIDE (MK-996-L-159,282) - A NEW ANGIOTENSIN-II RECEPTOR ANTAGONIST
CHAKRAVARTY, PK, NAYLOR, EM, CHEN, A, CHANG, RSL, CHEN, TB, FAUST, KA, LOTTI, VJ, KIVLIGHN, SD, GABLE, RA, ZINGARO, GJ, SCHORN, TW, SCHAFFER, LW, BROTEN, TP, SIEGL, PKS, PATCHETT, AA, GREENLEE, WJ
Published in Journal of medicinal chemistry (25.11.1994)
Published in Journal of medicinal chemistry (25.11.1994)
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Phenylacetamides as selective alpha-1A adrenergic receptor antagonists
Patane, M A, DiPardo, R M, Newton, R C, Price, R P, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Nagarathnam, D, Forray, C, Gluchowski, C, Bock, M G
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Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists
Nerenberg, J B, Erb, J M, Thompson, W J, Lee, H Y, Guare, J P, Munson, P M, Bergman, J M, Huff, J R, Broten, T P, Chang, R S, Chen, T B, O'Malley, S, Schorn, T W, Scott, A L
Published in Bioorganic & medicinal chemistry letters (22.09.1998)
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In vivo pharmacology of a novel AT selective angiotensin II receptor antagonist, MK-996
KIVLIGHN, S, ZINGARO, G, GABEL, R, BROTEN, T, SCHORN, T, SCHAFFER, L, NAYLOR, E, CHAKRAVARTY, P, PATCHETT, A, GREENLEE, W
Published in American journal of hypertension (01.01.1995)
Published in American journal of hypertension (01.01.1995)
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Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension
Siegl, P K, Kivlighn, S D, Broten, T P
Published in Journal of hypertension. Supplement (01.07.1995)
Published in Journal of hypertension. Supplement (01.07.1995)
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