Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
Fuller, Nathan O., Hubbs, Jed L., Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S., Tate, Barbara, Austin, Wesley F., Pojasek, Kevin, Xia, Weiming, McKee, Timothy D., Loureiro, Robyn M. B., Dumin, Jo Ann
Published in International journal of alzheimer's disease (2012)
Published in International journal of alzheimer's disease (2012)
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Journal Article
Optimization of a Natural Product-Based Class of γ‑Secretase Modulators
Hubbs, Jed L, Fuller, Nathan O, Austin, Wesley F, Shen, Ruichao, Creaser, Steffen P, McKee, Timothy D, Loureiro, Robyn M. B, Tate, Barbara, Xia, Weiming, Ives, Jeffrey, Bronk, Brian S
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Journal Article
In Vitro Microbiological Characterization of a Novel Azalide, Two Triamilides and an Azalide Ketal against Bovine and Porcine Respiratory Pathogens
NORCIA, LAURA J. L., SILVIA, ANNETTE M., SANTORO, SHERYL L., RETSEMA, JIM, LETAVIC, MICHAEL A., BRONK, BRIAN S., LUNDY, KRISTIN M., YANG, BINGWEI, EVANS, NIGEL A., HAYASHI, SHIGERU F.
Published in Journal of antibiotics (2004)
Published in Journal of antibiotics (2004)
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel alpha 7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O'Donnell, Christopher J., Rogers, Bruce N., Bronk, Brian S., Bryce, Dianne K., Coe, Jotham W., Cook, Karen K., Duplantier, Allen J., Evrard, Edelweiss, Hajos, Mihaly, Hoffmann, William E., Hurst, Raymond S., Maklad, Noha, Mather, Robert J., McLean, Stafford, Nedza, Frank M., O'Neill, Brian T., Peng, Langu, Qian, Weimin, Rottas, Melinda M., Sands, Steven B., Schmidt, Anne W., Shrikhande, Alka V., Spracklin, Douglas K., Wong, Diane F., Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Minimization of drug–drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators
Hubbs, Jed L., Fuller, Nathan O., Austin, Wesley F., Shen, Ruichao, Ma, Jianguo, Gong, Zhen, Li, Jian, McKee, Timothy D., Loureiro, Robyn M.B., Tate, Barbara, Dumin, Jo Ann, Ives, Jeffrey, Bronk, Brian S.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Journal Article
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O’Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O’Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ‑Secretase Modulator
Fuller, Nathan O, Hubbs, Jed L, Austin, Wesley F, Shen, Ruichao, Ives, Jeffrey, Osswald, Gerd, Bronk, Brian S
Published in Organic process research & development (20.06.2014)
Published in Organic process research & development (20.06.2014)
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Journal Article
Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models
Loureiro, Robyn M, Dumin, Jo Ann, McKee, Timothy D, Austin, Wesley F, Fuller, Nathan O, Hubbs, Jed L, Shen, Ruichao, Jonker, Jeff, Ives, Jeff, Bronk, Brian S, Tate, Barbara
Published in Alzheimer's research & therapy (18.04.2013)
Published in Alzheimer's research & therapy (18.04.2013)
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Journal Article
Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ‑Secretase Modulator
Shen, Ruichao, Fuller, Nathan O, Osswald, Gerd, Austin, Wesley F, Hubbs, Jed L, Haag, Dieter, Kovacs, Janos, Creaser, Steffen P, Findeis, Mark A, Ives, Jeffrey L, Bronk, Brian S
Published in Organic process research & development (20.06.2014)
Published in Organic process research & development (20.06.2014)
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Journal Article
Initial Optimization of a New Series of γ‑Secretase Modulators Derived from a Triterpene Glycoside
Fuller, Nathan O, Hubbs, Jed L, Austin, Wesley F, Creaser, Steffen P, McKee, Timothy D, Loureiro, Robyn M. B, Tate, Barbara, Xia, Weiming, Ives, Jeffrey L, Findeis, Mark A, Bronk, Brian S
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Journal Article
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014
Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Wood, Douglas E., Wood, Kathleen M., Van Deusen, Jeffrey W., Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease
Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Van Deusen, Jeffrey W., Wood, Douglas E., Wood, Kathleen M.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold
Austin, Wesley F, Hubbs, Jed L, Fuller, Nathan O, Creaser, Steffen P, McKee, Timothy D, Loureiro, Robyn M. B, Findeis, Mark A, Tate, Barbara, Ives, Jeffrey L, Bronk, Brian S
Published in MedChemComm (01.03.2013)
Published in MedChemComm (01.03.2013)
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Journal Article
In vitro and in vivo profile of 5-[(4' -trifluoromethyl -biphenyl -2-carbonyl ) -amino]-1H -indole -2 -carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity
JIN LI, BRONK, Brian S, HAVEN, Michelle L, KOLOSKO, Nicole L, BARRY, Chris J, MANION, Tara B, DIRLAM, John P, BLIZE, Alan E, BERTINATO, Peter, JAYNES, Burton H, HICKMAN, Anne, MISKELL, Christine, PILLAI, Usha A, TIBBITTS, Jay S
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Journal Article
P2-374: Small-molecule inhibitors of the receptor for advanced glycation end products (RAGE) are an effective therapy in animal models of Alzheimer's disease
Webster, Jeffrey C, Andrews, Robert, Shen, Jane, Majalli, Adnan M, Sahagan, Barbara G, Nelson, Robert B, Bronk, Brian S, Rothlein, Robert
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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Journal Article
Synthesis and Activity of a Novel Class of Tribasic Macrocyclic Antibiotics: The Triamilides
Letavic, Michael A., Bronk, Brian S., Bertsche, Camilla D., Casavant, Jeffrey M., Cheng, Hengmiao, Daniel, Kirsten L., George, David M., Hayashi, Shigeru F., Kamicker, Barbara J., Kolosko, Nicole L., Norcia, Laura J.L., Oberton, Vanessa D., Rushing, Margaret A., Santoro, Sheryl L.
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
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Journal Article
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
Li, Jin, Bertinato, Peter, Cheng, Hengmiao, Cole, Bridget M., Bronk, Brian S., Jaynes, Burton H., Hickman, Anne, Haven, Michelle L., Kolosko, Nicole L., Barry, Chris J., Manion, Tara B.
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article
In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor
Li, Jin, Lynch, Michael P., DeMello, Kristin Lundy, Sakya, Subas M., Cheng, Hengmiao, Rafka, Robert J., Bronk, Brian S., Jaynes, Burton H., Kilroy, Carolyn, Mann, Donald W., Haven, Michelle L., Kolosko, Nicole L., Petras, Carol, Seibel, Scott B., Lund, Lisa A.
Published in Bioorganic & medicinal chemistry (01.03.2005)
Published in Bioorganic & medicinal chemistry (01.03.2005)
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Journal Article
Synthesis, stereochemical assignment and biological activity of a novel series of C-4″ modified aza-Macrolides
Bronk, Brian S, Letavic, Michael A, Bertsche, Camilla D, George, David M, Hayashi, Shigeru F, Kamicker, Barbara J, Kolosko, Nicole L, Norcia, Laura J, Rushing, Margaret A, Santoro, Sheryl L, Yang, Bingwei V
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
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