SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile : Lack of tolerance and withdrawal anxiety
WOOD, M. D, REAVILL, C, RILEY, G, HOLLAND, V, BROMIDGE, S. M, FORBES, I. T, MIDDLEMISS, D. N, TRAIL, B, WILSON, A, STEAN, T, KENNETT, G. A, LIGHTOWLER, S, BLACKBURN, T. P, THOMAS, D, GAGER, T. L
Published in Neuropharmacology (01.08.2001)
Published in Neuropharmacology (01.08.2001)
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Journal Article
SB 202026: A Novel Muscarinic Partial Agonist with Functional Selectivity for M1 Receptors
Loudon, J M, Bromidge, S M, Brown, F, Clark, M S, Hatcher, J P, Hawkins, J, Riley, G J, Noy, G, Orlek, B S
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
Journal Article
Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist
Hagan, Jim J, Price, Gary W, Jeffrey, Phillip, Deeks, Nigel J, Stean, Tania, Piper, David, Smith, Martin I, Upton, Neil, Medhurst, Andrew D, Middlemiss, Derek N, Riley, Graham J, Lovell, Peter J, Bromidge, Steven M, Thomas, David R
Published in British journal of pharmacology (01.06.2000)
Published in British journal of pharmacology (01.06.2000)
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Journal Article
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents
BROMIDGE, S. M, DABBS, S, HOLLAND, V, KENNETT, G. A, LIGHTOWLER, S, MIDDLEMISS, D. N, RILEY, G. J, TRAIL, B, WOOD, M. D, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, JONES, G. E, JONES, J, KING, F. D, SAUNDERS, D. V, BLACKBURN, T. P
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Journal Article
5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): A potent, selective, and orally bioavailable 5-HT6 receptor antagonist
Bromidge, SM, Brown, AM, Clarke, SE, Dodgson, K, Gager, T, Grassam, HL, Jeffrey, PM, Joiner, GF, King, FD, Middlemiss, DN, Moss, SF, Newman, H, Riley, G, Routledge, C, Wyman, P
Published in Journal of medicinal chemistry (28.01.1999)
Published in Journal of medicinal chemistry (28.01.1999)
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Journal Article
Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonist
Routledge, Carol, Bromidge, Steven M, Moss, Stephen F, Price, Gary W, Hirst, Warren, Newman, Helen, Riley, Graham, Gager, Tracey, Stean, Tania, Upton, Neil, Clarke, Stephen E, Brown, Anthony M, Middlemiss, Derek N
Published in British journal of pharmacology (01.08.2000)
Published in British journal of pharmacology (01.08.2000)
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Journal Article
Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue
Hirst, Warren D, Minton, Jayne A L, Bromidge, Steven M, Moss, Stephen F, Latter, Alison J, Riley, Graham, Routledge, Carol, Middlemiss, Derek N, Price, Gary W
Published in British journal of pharmacology (01.08.2000)
Published in British journal of pharmacology (01.08.2000)
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Journal Article
Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
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Journal Article
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists : Identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
BROMIDGE, Steven M, CLARKE, Stephen E, NEWMAN, Helen, RILEY, Graham, ROGERS, Derek, ROUTLEDGE, Carol, SERAFINOWSKA, Halina, SMITH, Douglas R, GAGER, Tracey, GRIFFITH, Kerry, JEFFREY, Phillip, JENNINGS, Andrew J, JOINER, Graham F, KING, Frank D, LOVELL, Peter J, MOSS, Stephen F
Published in Bioorganic & medicinal chemistry letters (08.01.2001)
Published in Bioorganic & medicinal chemistry letters (08.01.2001)
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Journal Article
Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Duckworth, D. Malcolm, Forbes, Ian T, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Starr, Susannah, Thewlis, Kevin M, Wyman, Paul A, Blaney, Frank E, Naylor, Christopher B, Bailey, Fiona, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
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Journal Article
Design of [R-(Z)]-(+)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile (SB 202026), a Functionally Selective Azabicyclic Muscarinic M1 Agonist Incorporating the N-Methoxy Imidoyl Nitrile Group as a Novel Ester Bioisostere
Bromidge, Steven M, Brown, Frank, Cassidy, Frederick, Clark, Michael S. G, Dabbs, Steven, Hadley, Michael S, Hawkins, Julie, Loudon, Julia M, Naylor, Christopher B, Orlek, Barry S, Riley, Graham J
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Journal Article
6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist
Bromidge, Steven M, Duckworth, Malcolm, Forbes, Ian T, Ham, Peter, King, Frank D, Thewlis, Kevin M, Blaney, Frank E, Naylor, Christopher B, Blackburn, Thomas P, Kennett, Guy A, Wood, Martyn D, Clarke, Stephen E
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Journal Article
Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists
BROMIDGE, S. M, DABBS, S, SAUNDERS, D. V, THEWLIS, K. M, VYAS, D, BLACKBURN, T. P, HOLLAND, V, KENNETT, G. A, RILEY, G. J, WOOD, M. D, DAVIES, D. T, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, GADRE, A, HAM, P, JONES, G. E, KING, F. D
Published in Bioorganic & medicinal chemistry (01.12.1999)
Published in Bioorganic & medicinal chemistry (01.12.1999)
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Journal Article
Bridged 1,2,5,6-tetrahydropyridine esters and oxime ethers related to arecoline are novel and potent muscarinic agonists
Bromidge, Steven M., Cassidy, Frederick, Clark, Michael S.G., Faulkner, Richard E., Hadley, Michael S., Orlek, Barry S., Riley, Graham J., Stemp, Geoffrey
Published in Bioorganic & medicinal chemistry letters (19.05.1994)
Published in Bioorganic & medicinal chemistry letters (19.05.1994)
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Journal Article
1,2,5,6-tetrahydropyridine oxime ethers incorporating electron withdrawing groups are potent and selective muscarinic agonists
Bromidge, Steven M., Brown, Frank, Cassidy, Frederick, Clark, Michael S.G., Collings, Emma J., Dabbs, Steven, Faulkner, Richard E., Loudon, Julia M., Orlek, Barry S., Riley, Graham J.
Published in Bioorganic & medicinal chemistry letters (24.02.1994)
Published in Bioorganic & medicinal chemistry letters (24.02.1994)
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Journal Article
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Bromidge, S M, Dabbs, S, Davies, D T, Davies, S, Duckworth, D M, Forbes, I T, Gaster, L M, Ham, P, Jones, G E, King, F D, Mulholland, K R, Saunders, D V, Wyman, P A, Blaney, F E, Clarke, S E, Blackburn, T P, Holland, V, Kennett, G A, Lightowler, S, Middlemiss, D N, Trail, B, Riley, G J, Wood, M D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
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Journal Article
A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Lovell, Peter J, Bromidge, Steven M, Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T, Jennings, Andrew J, King, Frank D, Middlemiss, Derek N, Rahman, Shirley K, Saunders, Damian V, Collin, Lissa L, Hagan, Jim J, Riley, Graham J, Thomas, David R
Published in Journal of medicinal chemistry (10.02.2000)
Published in Journal of medicinal chemistry (10.02.2000)
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Journal Article
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor
Bromidge, S M, Griffith, K, Heightman, T D, Jennings, A, King, F D, Moss, S F, Newman, H, Riley, G, Routledge, C, Serafinowska, H T, Thomas, D R
Published in Bioorganic & medicinal chemistry letters (05.11.2001)
Published in Bioorganic & medicinal chemistry letters (05.11.2001)
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Journal Article