3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels
Collins, Ian, Moyes, Christopher, Davey, William B, Rowley, Michael, Bromidge, Frances A, Quirk, Kathleen, Atack, John R, McKernan, Ruth M, Thompson, Sally-Ann, Wafford, Keith, Dawson, Gerard R, Pike, Andrew, Sohal, Bindi, Tsou, Nancy N, Ball, Richard G, Castro, José L
Published in Journal of medicinal chemistry (25.04.2002)
Published in Journal of medicinal chemistry (25.04.2002)
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Journal Article
Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABAA Receptor Agonists at the α3 Subunit
Russell, Michael G. N, Carling, Robert W, Atack, John R, Bromidge, Frances A, Cook, Susan M, Hunt, Peter, Isted, Catherine, Lucas, Matt, McKernan, Ruth M, Mitchinson, Andrew, Moore, Kevin W, Narquizian, Robert, Macaulay, Alison J, Thomas, David, Thompson, Sally-Anne, Wafford, Keith A, Castro, José L
Published in Journal of medicinal chemistry (10.03.2005)
Published in Journal of medicinal chemistry (10.03.2005)
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Journal Article
Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site
Street, Leslie J, Sternfeld, Francine, Jelley, Richard A, Reeve, Austin J, Carling, Robert W, Moore, Kevin W, McKernan, Ruth M, Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R, Bromidge, Frances A, Wafford, Keith A, Seabrook, Guy R, Thompson, Sally A, Marshall, George, Pillai, Goplan V, Castro, José L, Atack, John R, MacLeod, Angus M
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article
Discovery of Imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 Subtype Selective Agonists for the Treatment of Anxiety
Russell, Michael G. N, Carling, Robert W, Street, Leslie J, Hallett, David J, Goodacre, Simon, Mezzogori, Elena, Reader, Michael, Cook, Susan M, Bromidge, Frances A, Newman, Robert, Smith, Alison J, Wafford, Keith A, Marshall, George R, Reynolds, David S, Dias, Rebecca, Ferris, Pushpindar, Stanley, Jo, Lincoln, Rachael, Tye, Spencer J, Sheppard, Wayne F. A, Sohal, Bindi, Pike, Andrew, Dominguez, Maria, Atack, John R, Castro, José L
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Journal Article
6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A α5 Receptor Inverse Agonists
Chambers, Mark S, Atack, John R, Bromidge, Frances A, Broughton, Howard B, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Maubach, Karen A, Reeve, Austin J, Seabrook, Guy R, Wafford, Keith, MacLeod, Angus M
Published in Journal of medicinal chemistry (14.03.2002)
Published in Journal of medicinal chemistry (14.03.2002)
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N-(indol-3-ylglyoxylyl)piperidines : High affinity agonists of human GABA-A receptors containing the α1 subunit
COLLINS, I, DAVEY, W. B, ROWLEY, M, QUIRK, K, BROMIDGE, F. A, MCKERNAN, R. M, THOMPSON, S.-A, WAFFORD, K. A
Published in Bioorganic & medicinal chemistry letters (19.06.2000)
Published in Bioorganic & medicinal chemistry letters (19.06.2000)
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Journal Article
Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice
Sur, Cyrille, Wafford, Keith A, Reynolds, David S, Hadingham, Karen L, Bromidge, Frances, Macaulay, Alison, Collinson, Neil, O'Meara, Gillian, Howell, Owain, Newman, Richard, Myers, Janice, Atack, John R, Dawson, Gerard R, McKernan, Ruth M, Whiting, Paul J, Rosahl, Thomas W
Published in The Journal of neuroscience (15.05.2001)
Published in The Journal of neuroscience (15.05.2001)
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Journal Article
Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice
Sur, C, Wafford, K A, Reynolds, D S, Hadingham, K L, Bromidge, F, Macaulay, A, Collinson, N, O'Meara, G, Howell, O, Newman, R, Myers, J, Atack, J R, Dawson, G R, McKernan, R M, Whiting, P J, Rosahl, T W
Published in The Journal of neuroscience (15.05.2001)
Published in The Journal of neuroscience (15.05.2001)
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Journal Article
Imidazo[1,2 -a]pyrimidines as functionally selective GABAA ligands
BLACKABY, Wesley P, ATACK, John R, STREET, Leslie J, TATTERSALL, David F. D, WAFFORD, Keith A, BROMIDGE, Frances, CASTRO, José L, GOODACRE, Simon C, HALLETT, David J, LEWIS, Richard T, MARSHALL, George R, PIKE, Andrew, SMITH, Alison J
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Identification of amino acid residues responsible for the α5 subunit binding selectivity of L‐655,708, a benzodiazepine binding site ligand at the GABAA receptor
Casula, M. Anna, Bromidge, Frances A., Pillai, Gopalan V., Wingrove, Peter B., Martin, Karine, Maubach, Karen, Seabrook, Guy R., Whiting, Paul J., Hadingham, Karen L.
Published in Journal of neurochemistry (01.04.2001)
Published in Journal of neurochemistry (01.04.2001)
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Journal Article
Imidazo[1,2- a]pyrimidines as functionally selective GABA A ligands
Blackaby, Wesley P., Atack, John R., Bromidge, Frances, Castro, José L., Goodacre, Simon C., Hallett, David J., Lewis, Richard T., Marshall, George R., Pike, Andrew, Smith, Alison J., Street, Leslie J., Tattersall, David F.D., Wafford, Keith A.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Pyrazolopyridinones as functionally selective GABAA ligands
BLACKABY, Wesley P, ATACK, John R, BROMIDGE, Frances, LEWIS, Richard, RUSSELL, Michael G. N, SMITH, Alison, WAFFORD, Keith, MCKERNAN, Ruth M, STREET, Leslie J, CASTRO, José L
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Pyrazolopyridinones as functionally selective GABA A ligands
Blackaby, Wesley P., Atack, John R., Bromidge, Frances, Lewis, Richard, Russell, Michael G.N., Smith, Alison, Wafford, Keith, McKernan, Ruth M., Street, Leslie J., Castro, José L.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Imidazo[1,2-a]pyrimidines as functionally selective GABA sub(A) ligands
Blackaby, Wesley P, Atack, John R, Bromidge, Frances, Castro, Jose L, Goodacre, Simon C, Hallett, David J, Lewis, Richard T, Marshall, George R, Pike, Andrew, Smith, Alison J, Street, Leslie J, Tattersall, David FD, Wafford, Keith A
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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Journal Article
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety
Russell, Michael G N, Carling, Robert W, Street, Leslie J, Hallett, David J, Goodacre, Simon, Mezzogori, Elena, Reader, Michael, Cook, Susan M, Bromidge, Frances A, Newman, Robert, Smith, Alison J, Wafford, Keith A, Marshall, George R, Reynolds, David S, Dias, Rebecca, Ferris, Pushpindar, Stanley, Jo, Lincoln, Rachael, Tye, Spencer J, Sheppard, Wayne F A, Sohal, Bindi, Pike, Andrew, Dominguez, Maria, Atack, John R, Castro, José L
Published in Journal of medicinal chemistry (23.02.2006)
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Published in Journal of medicinal chemistry (23.02.2006)
Journal Article
Discovery of Imidazo[1,2- b ][1,2,4]triazines as GABA A α2/3 Subtype Selective Agonists for the Treatment of Anxiety
Russell, Michael G. N., Carling, Robert W., Street, Leslie J., Hallett, David J., Goodacre, Simon, Mezzogori, Elena, Reader, Michael, Cook, Susan M., Bromidge, Frances A., Newman, Robert, Smith, Alison J., Wafford, Keith A., Marshall, George R., Reynolds, David S., Dias, Rebecca, Ferris, Pushpindar, Stanley, Jo, Lincoln, Rachael, Tye, Spencer J., Sheppard, Wayne F. A., Sohal, Bindi, Pike, Andrew, Dominguez, Maria, Atack, John R., Castro, José L.
Published in Journal of medicinal chemistry (01.02.2006)
Published in Journal of medicinal chemistry (01.02.2006)
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Journal Article
Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit
Russell, Michael G N, Carling, Robert W, Atack, John R, Bromidge, Frances A, Cook, Susan M, Hunt, Peter, Isted, Catherine, Lucas, Matt, McKernan, Ruth M, Mitchinson, Andrew, Moore, Kevin W, Narquizian, Robert, Macaulay, Alison J, Thomas, David, Thompson, Sally-Anne, Wafford, Keith A, Castro, José L
Published in Journal of medicinal chemistry (10.03.2005)
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Published in Journal of medicinal chemistry (10.03.2005)
Journal Article
Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4- a ]phthalazines as GABA A Receptor Agonists at the α 3 Subunit
Russell, Michael G. N., Carling, Robert W., Atack, John R., Bromidge, Frances A., Cook, Susan M., Hunt, Peter, Isted, Catherine, Lucas, Matt, McKernan, Ruth M., Mitchinson, Andrew, Moore, Kevin W., Narquizian, Robert, Macaulay, Alison J., Thomas, David, Thompson, Sally-Anne, Wafford, Keith A., Castro, José L.
Published in Journal of medicinal chemistry (01.03.2005)
Published in Journal of medicinal chemistry (01.03.2005)
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Journal Article
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site
Street, Leslie J, Sternfeld, Francine, Jelley, Richard A, Reeve, Austin J, Carling, Robert W, Moore, Kevin W, McKernan, Ruth M, Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R, Bromidge, Frances A, Wafford, Keith A, Seabrook, Guy R, Thompson, Sally A, Marshall, George, Pillai, Goplan V, Castro, José L, Atack, John R, MacLeod, Angus M
Published in Journal of medicinal chemistry (01.07.2004)
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Published in Journal of medicinal chemistry (01.07.2004)
Journal Article
Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4- a ]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABA A α5 Benzodiazepine Binding Site
Street, Leslie J., Sternfeld, Francine, Jelley, Richard A., Reeve, Austin J., Carling, Robert W., Moore, Kevin W., McKernan, Ruth M., Sohal, Bindi, Cook, Susan, Pike, Andrew, Dawson, Gerard R., Bromidge, Frances A., Wafford, Keith A., Seabrook, Guy R., Thompson, Sally A., Marshall, George, Pillai, Goplan V., Castro, José L., Atack, John R., MacLeod, Angus M.
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article