Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor
Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.
Published in Cell (29.01.2015)
Published in Cell (29.01.2015)
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PHLiPPing the switch on Akt and protein kinase C signaling
Brognard, John, Newton, Alexandra C
Published in Trends in endocrinology and metabolism (01.08.2008)
Published in Trends in endocrinology and metabolism (01.08.2008)
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Serine-linked PARP1 auto-modification controls PARP inhibitor response
Prokhorova, Evgeniia, Zobel, Florian, Smith, Rebecca, Zentout, Siham, Gibbs-Seymour, Ian, Schützenhofer, Kira, Peters, Alessandra, Groslambert, Joséphine, Zorzini, Valentina, Agnew, Thomas, Brognard, John, Nielsen, Michael L., Ahel, Dragana, Huet, Sébastien, Suskiewicz, Marcin J., Ahel, Ivan
Published in Nature communications (01.07.2021)
Published in Nature communications (01.07.2021)
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The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C
Gao, Tianyan, Brognard, John, Newton, Alexandra C.
Published in The Journal of biological chemistry (07.03.2008)
Published in The Journal of biological chemistry (07.03.2008)
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Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy
Puto, Lorena A., Brognard, John, Hunter, Tony
Published in The Journal of biological chemistry (19.06.2015)
Published in The Journal of biological chemistry (19.06.2015)
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TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin
Torres-Ayuso, Pedro, An, Elvira, Nyswaner, Katherine M, Bensen, Ryan C, Ritt, Daniel A, Specht, Suzanne I, Das, Sudipto, Andresson, Thorkell, Cachau, Raul E, Liang, Roger J, Ries, Amy L, Robinson, Christina M, Difilippantonio, Simone, Gouker, Brad, Bassel, Laura, Karim, Baktiar O, Miller, Chad J, Turk, Benjamin E, Morrison, Deborah K, Brognard, John
Published in Cancer discovery (01.06.2021)
Published in Cancer discovery (01.06.2021)
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Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor-Suppressing Kinase
BROGNARD, John, ZHANG, You-Wei, PUTO, Lorena A, HUNTER, Tony
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
Zhang, You-Wei, Brognard, John, Coughlin, Chris, You, Zhongsheng, Dolled-Filhart, Marisa, Aslanian, Aaron, Manning, Gerard, Abraham, Robert T., Hunter, Tony
Published in Molecular cell (28.08.2009)
Published in Molecular cell (28.08.2009)
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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
Marusiak, Anna A., Edwards, Zoe C., Hugo, Willy, Trotter, Eleanor W., Girotti, Maria R., Stephenson, Natalie L., Kong, Xiangju, Gartside, Michael G., Fawdar, Shameem, Hudson, Andrew, Breitwieser, Wolfgang, Hayward, Nicholas K., Marais, Richard, Lo, Roger S., Brognard, John
Published in Nature communications (22.05.2014)
Published in Nature communications (22.05.2014)
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Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
Fawdar, Shameem, Trotter, Eleanor W., Li, Yaoyong, Stephenson, Natalie L., Hanke, Franziska, Marusiak, Anna A., Edwards, Zoe C., Ientile, Sara, Waszkowycz, Bohdan, Miller, Crispin J., Brognard, John
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
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Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery
Hudson, Andrew M, Yates, Tim, Li, Yaoyong, Trotter, Eleanor W, Fawdar, Shameem, Chapman, Phil, Lorigan, Paul, Biankin, Andrew, Miller, Crispin J, Brognard, John
Published in Cancer research (Chicago, Ill.) (15.11.2014)
Published in Cancer research (Chicago, Ill.) (15.11.2014)
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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
West, Kip A, Brognard, John, Clark, Amy S, Linnoila, Ilona R, Yang, Xiaowei, Swain, Sandra M, Harris, Curtis, Belinsky, Steven, Dennis, Phillip A
Published in The Journal of clinical investigation (01.01.2003)
Published in The Journal of clinical investigation (01.01.2003)
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Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output
Reyes, Gloria, Niederst, Matt, Cohen-Katsenelson, Ksenya, Stender, Joshua D, Kunkel, Maya T, Chen, Muhan, Brognard, John, Sierecki, Emma, Gao, Tianyan, Nowak, Dawid G, Trotman, Lloyd C, Glass, Christopher K, Newton, Alexandra C
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
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Somatically mutated ABL1 is an actionable and essential NSCLC survival gene
Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John
Published in EMBO molecular medicine (01.02.2016)
Published in EMBO molecular medicine (01.02.2016)
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The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells
Brumbaugh, Kathryn M., Otterness, Diane M., Geisen, Christoph, Oliveira, Vasco, Brognard, John, Li, Xiaojie, Lejeune, Fabrice, Tibbetts, Randal S., Maquat, Lynne E., Abraham, Robert T.
Published in Molecular cell (04.06.2004)
Published in Molecular cell (04.06.2004)
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