Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1
Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Journal Article
Antimony Uptake Systems in the Protozoan Parasite Leishmania and Accumulation Differences in Antimony-Resistant Parasites
BROCHU, Christian, JINGYU WANG, ROY, Gaétan, MESSIER, Nadine, WANG, Xiao-Yan, SARAVIA, Nancy G, OUELLETTE, Marc
Published in Antimicrobial Agents and Chemotherapy (01.10.2003)
Published in Antimicrobial Agents and Chemotherapy (01.10.2003)
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Journal Article
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds
Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
Stability, Reactivity, Solution, and Solid-State Structure of Halomethylzinc Alkoxides
Charette, André B, Molinaro, Carmela, Brochu, Christian
Published in Journal of the American Chemical Society (12.12.2001)
Published in Journal of the American Chemical Society (12.12.2001)
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Journal Article
Improved Procedure for the Synthesis of Enantiomerically Enriched Cyclopropylmethanol Derivatives
Charette, Andre B, Prescott, Sylvie, Brochu, Christian
Published in Journal of organic chemistry (01.02.1995)
Published in Journal of organic chemistry (01.02.1995)
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Journal Article
Preparation, Solid-State Structure, and Synthetic Applications of Isolable and Storable Haloalkylzinc Reagents
Charette, André B, Marcoux, Jean-François, Molinaro, Carmela, Beauchemin, André, Brochu, Christian, Isabel, Élise
Published in Journal of the American Chemical Society (10.05.2000)
Published in Journal of the American Chemical Society (10.05.2000)
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Journal Article
A new strategy for the Lewis acid-catalyzed cyclopropanation of allylic alcohols
Charette, Andre B, Brochu, Christian
Published in Journal of the American Chemical Society (01.11.1995)
Published in Journal of the American Chemical Society (01.11.1995)
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Journal Article
Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127)
LaPlante, Steven R., Bös, Michael, Brochu, Christian, Chabot, Catherine, Coulombe, René, Gillard, James R., Jakalian, Araz, Poirier, Martin, Rancourt, Jean, Stammers, Timothy, Thavonekham, Bounkham, Beaulieu, Pierre L., Kukolj, George, Tsantrizos, Youla S.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B
LaPlante, Steven R, Gillard, James R, Jakalian, Araz, Aubry, Norman, Coulombe, René, Brochu, Christian, Tsantrizos, Youla S, Poirier, Martin, Kukolj, George, Beaulieu, Pierre L
Published in Journal of the American Chemical Society (03.11.2010)
Published in Journal of the American Chemical Society (03.11.2010)
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Journal Article
Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency
Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
A novel cis -acting element from the 3′UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression
Melanson, Brian D., Cabrita, Miguel A., Bose, Reetesh, Hamill, Jeffrey D., Pan, Elysia, Brochu, Christian, Marcellus, Kristen A., Zhao, Tong T., Holcik, Martin, McKay, Bruce C.
Published in Nucleic acids research (01.06.2013)
Published in Nucleic acids research (01.06.2013)
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Journal Article
Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection
Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061
Llinàs-Brunet, Montse, Bailey, Murray D, Bolger, Gordon, Brochu, Christian, Faucher, Anne-Marie, Ferland, Jean Marie, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Grand-Maître, Chantal, Halmos, Ted, Lapeyre-Paquette, Nicole, Liard, Francine, Poirier, Martin, Rhéaume, Manon, Tsantrizos, Youla S, Lamarre, Daniel
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Journal Article
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus
Décor, Anne, Grand-Maître, Chantal, Hucke, Oliver, O’Meara, Jeff, Kuhn, Cyrille, -Forget, Léa Constantineau, Brochu, Christian, Malenfant, Eric, Bertrand-Laperle, Mégan, Bordeleau, Josée, Ghiro, Elise, Pesant, Marc, Fazal, Gulrez, Gorys, Vida, Little, Michael, Boucher, Colette, Bordeleau, Sylvain, Turcotte, Pascal, Guo, Tim, Garneau, Michel, Spickler, Catherine, Gauthier, Annick
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression
Melanson, Brian D, Cabrita, Miguel A, Bose, Reetesh, Hamill, Jeffrey D, Pan, Elysia, Brochu, Christian, Marcellus, Kristen A, Zhao, Tong T, Holcik, Martin, McKay, Bruce C
Published in Nucleic acids research (01.06.2013)
Published in Nucleic acids research (01.06.2013)
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Journal Article
Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans
Faucher, Anne-Marie, Bailey, Murray D, Beaulieu, Pierre L, Brochu, Christian, Duceppe, Jean-Simon, Ferland, Jean-Marie, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Kawai, Stephen H, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S, Llinàs-Brunet, Montse
Published in Organic letters (19.08.2004)
Published in Organic letters (19.08.2004)
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