Search Results - "BRITT-MARIE SWAHN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

by Jeppsson, Fredrik, Eketjäll, Susanna, Janson, Juliette, Karlström, Sofia, Gustavsson, Susanne, Olsson, Lise-Lotte, Radesäter, Ann-Cathrine, Ploeger, Bart, Cebers, Gvido, Kolmodin, Karin, Swahn, Britt-Marie, von Berg, Stefan, Bueters, Tjerk, Fälting, Johanna
Published in The Journal of biological chemistry (30.11.2012)

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Journal Article

Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand

Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand

by Juréus, Anders, Swahn, Britt-Marie, Sandell, Johan, Jeppsson, Fredrik, Johnson, Allan E, Johnström, Peter, Neelissen, Jan A.M, Sunnemark, Dan, Farde, Lars, Svensson, Samuel P.S
Published in Journal of neurochemistry (01.08.2010)

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Journal Article

Radiosynthesis of the candidate β-amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys

Radiosynthesis of the candidate β-amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys

by Andersson, Jan D., Varnäs, Katarina, Cselényi, Zsolt, Gulyás, Balázs, Wensbo, David, Finnema, Sjoerd J., Swahn, Britt-Marie, Svensson, Samuel, Nyberg, Svante, Farde, Lars, Halldin, Christer
Published in Synapse (New York, N.Y.) (01.10.2010)

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Journal Article

New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain

by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik
Published in Journal of medicinal chemistry (08.11.2012)

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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides

by Swahn, Britt-Marie, Kolmodin, Karin, Karlström, Sofia, von Berg, Stefan, Söderman, Peter, Holenz, Jörg, Berg, Stefan, Lindström, Johan, Sundström, Marie, Turek, Dominika, Kihlström, Jacob, Slivo, Can, Andersson, Lars, Pyring, David, Rotticci, Didier, Öhberg, Liselotte, Kers, Annika, Bogar, Krisztian, von Kieseritzky, Fredrik, Bergh, Margareta, Olsson, Lise-Lotte, Janson, Juliette, Eketjäll, Susanna, Georgievska, Biljana, Jeppsson, Fredrik, Fälting, Johanna
Published in Journal of medicinal chemistry (08.11.2012)

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Journal Article

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

by Luker, Tim, Alcaraz, Lilian, Chohan, Kamaldeep K., Blomberg, Niklas, Brown, Dearg S., Butlin, Roger J., Elebring, Thomas, Griffin, Andrew M., Guile, Simon, St-Gallay, Stephen, Swahn, Britt-Marie, Swallow, Steve, Waring, Michael J., Wenlock, Mark C., Leeson, Paul D.
Published in Bioorganic & medicinal chemistry letters (01.10.2011)

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Journal Article

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice

by Eketjäll, Susanna, Janson, Juliette, Jeppsson, Fredrik, Svanhagen, Alexander, Kolmodin, Karin, Gustavsson, Susanne, Radesäter, Ann-Cathrin, Eliason, Kristina, Briem, Sveinn, Appelkvist, Paulina, Niva, Camilla, Berg, Anna-Lena, Karlström, Sofia, Swahn, Britt-Marie, Fälting, Johanna
Published in The Journal of neuroscience (12.06.2013)

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Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy

Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy

by Viklund, Jenny, Kolmodin, Karin, Nordvall, Gunnar, Swahn, Britt-Marie, Svensson, Mats, Gravenfors, Ylva, Rahm, Fredrik
Published in ACS medicinal chemistry letters (10.04.2014)

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Journal Article

Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3

by Swahn, Britt-Marie, Xue, Yafeng, Arzel, Erwan, Kallin, Elisabet, Magnus, Angelika, Plobeck, Niklas, Viklund, Jenny
Published in Bioorganic & medicinal chemistry letters (01.03.2006)

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Journal Article

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

by Forsberg, Anton, Juréus, Anders, Cselényi, Zsolt, Eriksdotter, Maria, Freund-Levi, Yvonne, Jeppsson, Fredrik, Swahn, Britt-Marie, Sandell, Johan, Julin, Per, Schou, Magnus, Andersson, Jan, Johnström, Peter, Varnäs, Katarina, Halldin, Christer, Farde, Lars, Svensson, Samuel
Published in European journal of nuclear medicine and molecular imaging (2013)

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Journal Article

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

by Swahn, Britt-Marie, Huerta, Fernando, Kallin, Elisabet, Malmström, Jonas, Weigelt, Tatjana, Viklund, Jenny, Womack, Patrick, Xue, Yafeng, Öhberg, Liselotte
Published in Bioorganic & medicinal chemistry letters (15.11.2005)

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Journal Article

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

by Swahn, Britt-Marie, Holenz, Jörg, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, Plobeck, Niklas, Rotticci, Didier, Sehgelmeble, Fernando, Sundström, Marie, Berg, Stefan von, Fälting, Johanna, Georgievska, Biljana, Gustavsson, Susanne, Neelissen, Jan, Ek, Margareta, Olsson, Lise-Lotte, Berg, Stefan
Published in Bioorganic & medicinal chemistry letters (01.03.2012)

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Journal Article

Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

by Swahn, Britt-Marie, Macsari, Istvan, Viklund, Jenny, Öhberg, Liselotte, Sjödin, Johanna, Neelissen, Jan, Lindquist, Johanna
Published in Bioorganic & medicinal chemistry letters (01.04.2009)

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Journal Article

COMPOUNDS AND THEIR USE AS BACE INHIBITORS

COMPOUNDS AND THEIR USE AS BACE INHIBITORS

by STEFAN VON BERG, LARS SANDBERG, KARIN KOLMODIN, ANNIKA KERS, SOFIA KARLSTROEM, PETER SODERMAN, GABOR CSJERNYIK, FERNANDO SEHGELMEBLE, BRITT-MARIE SWAHN, MARTIN NYLOF, LISELOTTE OHBERG, LASZLO RAKOS
Year of Publication 31.05.2018

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Patent

COMPOUNDS AND THEIR USE AS BACE INHIBITORS

COMPOUNDS AND THEIR USE AS BACE INHIBITORS

by STEFAN VON BERG, LARS SANDBERG, KARIN KOLMODIN, ANNIKA KERS, SOFIA KARLSTROEM, PETER SODERMAN, GABOR CSJERNYIK, FERNANDO SEHGELMEBLE, BRITT-MARIE SWAHN, MARTIN NYLOF, LISELOTTE OHBERG, LASZLO RAKOS
Year of Publication 12.01.2017

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Patent

ChemInform Abstract: Synthesis and Evaluation of Pyridylbenzofuran, Pyridylbenzothiazole and Pyridylbenzoxazole Derivatives as 18F-PET Imaging Agents for β-Amyloid Plaques

ChemInform Abstract: Synthesis and Evaluation of Pyridylbenzofuran, Pyridylbenzothiazole and Pyridylbenzoxazole Derivatives as 18F-PET Imaging Agents for β-Amyloid Plaques

by Swahn, Britt-Marie, ., et al
Published in ChemInform (30.10.2012)

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Journal Article

New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

by Swahn, Britt-Marie, Claesson, Alf, Pelcman, Benjamin, Besidski, Yevgeni, Molin, Håkan, Sandberg, Mats P., Berge, Odd-Geir
Published in Bioorganic & medicinal chemistry letters (23.07.1996)

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Journal Article

Competitive NMDA antagonist that base their activity on a unique conformational effect

Competitive NMDA antagonist that base their activity on a unique conformational effect

by Claesson, Alf, Swahn, Britt-Marie, Edvinsson, Karin M., Molin, H»kan, Sandberg, Mats
Published in Bioorganic & medicinal chemistry letters (1992)

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Journal Article

Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity

Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity

by Swahn, Britt-Marie, Edvinsson, Karin M., Kallin, Elisabet, Larsson, Ulf, Berge, Odd-Geir, Molin, Håkan, Pelcman, Benjamin, Claesson, Alf
Published in Bioorganic & medicinal chemistry (01.07.1997)

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Journal Article

Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

Biotransformation of two β-secretase inhibitors including ring opening and contraction of a pyrimidine ring

by Lindgren, Anders, Eklund, Göran, Turek, Dominika, Malmquist, Jonas, Swahn, Britt-Marie, Holenz, Jörg, von Berg, Stefan, Karlström, Sofia, Bueters, Tjerk
Published in Drug metabolism and disposition (01.05.2013)

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Journal Article

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