Engineering therapeutic bispecific antibodies using CrossMab technology
Klein, Christian, Schaefer, Wolfgang, Regula, Joerg T., Dumontet, Charles, Brinkmann, Ulrich, Bacac, Marina, Umaña, Pablo
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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Journal Article
Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression
Buntz, Annette, Killian, Tobias, Schmid, Daniela, Seul, Heike, Brinkmann, Ulrich, Ravn, Jacob, Lindholm, Marie, Knoetgen, Hendrik, Haucke, Volker, Mundigl, Olaf
Published in Nucleic acids research (25.01.2019)
Published in Nucleic acids research (25.01.2019)
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DPH1 and DPH2 variants that confer susceptibility to diphthamide deficiency syndrome in human cells and yeast models
Ütkür, Koray, Mayer, Klaus, Khan, Maliha, Manivannan, Thirishika, Schaffrath, Raffael, Brinkmann, Ulrich
Published in Disease models & mechanisms (01.09.2023)
Published in Disease models & mechanisms (01.09.2023)
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Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
Dengl, Stefan, Mayer, Klaus, Bormann, Felix, Duerr, Harald, Hoffmann, Eike, Nussbaum, Bianca, Tischler, Michael, Wagner, Martina, Kuglstatter, Andreas, Leibrock, Lea, Buldun, Can, Georges, Guy, Brinkmann, Ulrich
Published in Nature communications (02.10.2020)
Published in Nature communications (02.10.2020)
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Journal Article
Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis
Zhang, Hongliang, Quintana, Julia, Ütkür, Koray, Adrian, Lorenz, Hawer, Harmen, Mayer, Klaus, Gong, Xiaodi, Castanedo, Leonardo, Schulten, Anna, Janina, Nadežda, Peters, Marcus, Wirtz, Markus, Brinkmann, Ulrich, Schaffrath, Raffael, Krämer, Ute
Published in Nature communications (11.07.2022)
Published in Nature communications (11.07.2022)
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Journal Article
Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast
Hawer, Harmen, Ütkür, Koray, Arend, Meike, Mayer, Klaus, Adrian, Lorenz, Brinkmann, Ulrich, Schaffrath, Raffael
Published in PloS one (18.10.2018)
Published in PloS one (18.10.2018)
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Journal Article
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Klein, Christian, Sustmann, Claudio, Thomas, Markus, Stubenrauch, Kay, Croasdale, Rebecca, Schanzer, Jürgen, Brinkmann, Ulrich, Kettenberger, Hubert, Regula, Jörg T., Schaefer, Wolfgang
Published in mAbs (01.11.2012)
Published in mAbs (01.11.2012)
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Journal Article
DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2
Ütkür, Koray, Schmidt, Sarina, Mayer, Klaus, Klassen, Roland, Brinkmann, Ulrich, Schaffrath, Raffael
Published in Biomolecules (Basel, Switzerland) (16.11.2023)
Published in Biomolecules (Basel, Switzerland) (16.11.2023)
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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy
Vasic, Vedran, Buldun, Can, Ritz, Manfred, Dickopf, Steffen, Georges, Guy J., Spick, Christian, Peuker, Alessa, Meier, Thomas, Mayer, Klaus, Brinkmann, Ulrich
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
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Journal Article
Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress
Mayer, Klaus, Mundigl, Olaf, Kettenberger, Hubert, Birzele, Fabian, Stahl, Sebastian, Pastan, Ira, Brinkmann, Ulrich
Published in Redox biology (01.01.2019)
Published in Redox biology (01.01.2019)
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Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Stahl, Sebastian, Seidl, Ana Rita da Silva Mateus, Ducret, Axel, van Geijtenbeek, Sabine Kux, Michel, Sven, Racek, Tomas, Birzele, Fabian, Haas, Alexander K., Rueger, Ruediger, Gerg, Michael, Niederfellner, Gerhard, Pastan, Ira, Brinkmann, Ulrich
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2015)
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Journal Article
A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular Properties
Schanzer, Juergen M., Wartha, Katharina, Croasdale, Rebecca, Moser, Samuel, Künkele, Klaus-Peter, Ries, Carola, Scheuer, Werner, Duerr, Harald, Pompiati, Sandra, Pollman, Jan, Stracke, Jan, Lau, Wilma, Ries, Stefan, Brinkmann, Ulrich, Klein, Christian, Umana, Pablo
Published in The Journal of biological chemistry (04.07.2014)
Published in The Journal of biological chemistry (04.07.2014)
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Journal Article
Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2
Arend, Meike, Ütkür, Koray, Hawer, Harmen, Mayer, Klaus, Ranjan, Namit, Adrian, Lorenz, Brinkmann, Ulrich, Schaffrath, Raffael
Published in Microbial cell (04.09.2023)
Published in Microbial cell (04.09.2023)
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A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors
Thomas, Markus, Kienast, Yvonne, Scheuer, Werner, Bähner, Monika, Kaluza, Klaus, Gassner, Christian, Herting, Frank, Brinkmann, Ulrich, Seeber, Stefan, Kavlie, Anita, Welschof, Martin, Ries, Stefan, Weidner, K Michael, Regula, Jörg T, Klein, Christian
Published in PloS one (06.02.2013)
Published in PloS one (06.02.2013)
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Journal Article
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy
Bauss, Frieder, Lechmann, Martin, Krippendorff, Ben-Fillippo, Staack, Roland, Herting, Frank, Festag, Matthias, Imhof-Jung, Sabine, Hesse, Friederike, Pompiati, Marc, Kollmorgen, Gwendlyn, da Silva Mateus Seidl, Rita, Bossenmaier, Birgit, Lau, Wilma, Schantz, Christian, Stracke, Jan O., Brinkmann, Ulrich, Onda, Masanori, Pastan, Ira, Bosslet, Klaus, Niederfellner, Gerhard
Published in Molecular oncology (01.10.2016)
Published in Molecular oncology (01.10.2016)
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Journal Article
Bispecific digoxigenin-binding antibodies for targeted payload delivery
Metz, Silke, Haas, Alexander K, Daub, Karin, Croasdale, Rebecca, Stracke, Jan, Lau, Wilma, Georges, Guy, Josel, Hans-Peter, Dziadek, Sebastian, Hopfner, Karl-Peter, Lammens, Alfred, Scheuer, Werner, Hoffmann, Eike, Mundigl, Olaf, Brinkmann, Ulrich
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
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Journal Article
Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains
Schanzer, Jürgen, Jekle, Andreas, Nezu, Junichi, Lochner, Adriane, Croasdale, Rebecca, Dioszegi, Marianna, Zhang, Jun, Hoffmann, Eike, Dormeyer, Wilma, Stracke, Jan, Schäfer, Wolfgang, Ji, Changhua, Heilek, Gabrielle, Cammack, Nick, Brandt, Michael, Umana, Pablo, Brinkmann, Ulrich
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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