LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
Coskun, Tamer, Urva, Shweta, Roell, William C., Qu, Hongchang, Loghin, Corina, Moyers, Julie S., O’Farrell, Libbey S., Briere, Daniel A., Sloop, Kyle W., Thomas, Melissa K., Pirro, Valentina, Wainscott, David B., Willard, Francis S., Abernathy, Matthew, Morford, LaRonda, Du, Yu, Benson, Charles, Gimeno, Ruth E., Haupt, Axel, Milicevic, Zvonko
Published in Cell metabolism (06.09.2022)
Published in Cell metabolism (06.09.2022)
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice
Briere, Daniel A, Ruan, Xiaoping, Cheng, Christine C, Siesky, Angela M, Fitch, Thomas E, Dominguez, Carmen, Sanfeliciano, Sonia Gutierrez, Montero, Carlos, Suen, Chen S, Xu, Yanping, Coskun, Tamer, Michael, M Dodson
Published in PloS one (27.08.2015)
Published in PloS one (27.08.2015)
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The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP‐1 receptor agonists
Urva, Shweta, Coskun, Tamer, Loghin, Corina, Cui, Xuewei, Beebe, Emily, O'Farrell, Libbey, Briere, Daniel A., Benson, Charles, Nauck, Michael A., Haupt, Axel
Published in Diabetes, obesity & metabolism (01.10.2020)
Published in Diabetes, obesity & metabolism (01.10.2020)
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Journal Article
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior
Samms, Ricardo J, Cosgrove, Richard, Snider, Brandy M, Furber, Ellen C, Droz, Brian A, Briere, Daniel A, Dunbar, James, Dogra, Mridula, Alsina-Fernandez, Jorge, Borner, Tito, De Jonghe, Bart C, Hayes, Matthew R, Coskun, Tamer, Sloop, Kyle W, Emmerson, Paul J, Ai, Minrong
Published in Diabetes (New York, N.Y.) (01.07.2022)
Published in Diabetes (New York, N.Y.) (01.07.2022)
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Mechanisms to Elevate Endogenous GLP-1 Beyond Injectable GLP-1 Analogs and Metabolic Surgery
Briere, Daniel A, Bueno, Ana B, Gunn, Ellen J, Michael, M Dodson, Sloop, Kyle W
Published in Diabetes (New York, N.Y.) (01.02.2018)
Published in Diabetes (New York, N.Y.) (01.02.2018)
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Journal Article
Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor
Willard, Francis S, Wainscott, David B, Showalter, Aaron D, Stutsman, Cynthia, Ma, Wenzhen, Cardona, Guemalli R, Zink, Richard W, Corkins, Christopher M, Chen, Qi, Yumibe, Nathan, Agejas, Javier, Cumming, Graham R, Minguez, José Miguel, Jiménez, Alma, Mateo, Ana I, Castaño, Ana M, Briere, Daniel A, Sloop, Kyle W, Bueno, Ana B
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function
Lin, Hua V., Wang, Jingru, Wang, Jie, Li, Weiji, Wang, Xuesong, Alston, James T., Thomas, Melissa K., Briere, Daniel A., Syed, Samreen K., Efanov, Alexander M.
Published in Molecular metabolism (Germany) (01.05.2018)
Published in Molecular metabolism (Germany) (01.05.2018)
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Journal Article
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
Samms, Ricardo J, Christe, Michael E, Collins, Kyla A, Pirro, Valentina, Droz, Brian A, Holland, Adrienne K, Friedrich, Jessica L, Wojnicki, Samantha, Konkol, Debra L, Cosgrove, Richard, Conceição Furber, Ellen Ps, Ruan, Xiaoping, O'Farrell, Libbey S, Long, Annie M, Dogra, Mridula, Willency, Jill A, Lin, Yanzhu, Ding, Liyun, Cheng, Christine C, Cabrera, Over, Briere, Daniel A, Alsina-Fernandez, Jorge, Gimeno, Ruth E, Moyers, Julie S, Coskun, Tamer, Coghlan, Matthew P, Sloop, Kyle W, Roell, William C
Published in The Journal of clinical investigation (15.06.2021)
Published in The Journal of clinical investigation (15.06.2021)
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Journal Article
Activation of Prostaglandin E Receptor 4 Triggers Secretion of Gut Hormone Peptides GLP-1, GLP-2, and PYY
Coskun, Tamer, O'Farrell, Libbey S, Syed, Samreen K, Briere, Daniel A, Beavers, Lisa S, DuBois, Susan L, Michael, Mervyn D, Franciskovich, Jeffry B, Barrett, David G, Efanov, Alexander M
Published in Endocrinology (Philadelphia) (01.01.2013)
Published in Endocrinology (Philadelphia) (01.01.2013)
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Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3
Engler, Thomas A, Henry, James R, Malhotra, Sushant, Cunningham, Brian, Furness, Kelly, Brozinick, Joseph, Burkholder, Timothy P, Clay, Michael P, Clayton, Joshua, Diefenbacher, Clive, Hawkins, Eric, Iversen, Philip W, Li, Yihong, Lindstrom, Terry D, Marquart, Angela L, McLean, Johnathan, Mendel, David, Misener, Elizabeth, Briere, Daniel, O'Toole, John C, Porter, Warren J, Queener, Steven, Reel, Jon K, Owens, Rebecca A, Brier, Richard A, Eessalu, Thomas E, Wagner, Jill R, Campbell, Robert M, Vaughn, Renee
Published in Journal of medicinal chemistry (29.07.2004)
Published in Journal of medicinal chemistry (29.07.2004)
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2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents
Martín, José A., Brooks, Dawn A., Prieto, Lourdes, González, Rosario, Torrado, Alicia, Rojo, Isabel, López de Uralde, Beatriz, Lamas, Carlos, Ferritto, Rafael, Dolores Martín-Ortega, María, Agejas, Javier, Parra, Francisco, Rizzo, John R., Rhodes, Gary A., Robey, Roger L., Alt, Charles A., Wendel, Samuel R., Zhang, Tony Y., Reifel-Miller, Anne, Montrose-Rafizadeh, Chahrzad, Brozinick, Joseph T., Hawkins, Eric, Misener, Elizabeth A., Briere, Daniel A., Ardecky, Robert, Fraser, James D., Warshawsky, Alan M.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Journal Article
The development of potent and selective bisarylmaleimide GSK3 inhibitors
Engler, Thomas A., Malhotra, Sushant, Burkholder, Timothy P., Henry, James R., Mendel, David, Porter, Warren J., Furness, Kelly, Diefenbacher, Clive, Marquart, Angela, Reel, Jon K., Li, Yihong, Clayton, Joshua, Cunningham, Brian, McLean, Johnathan, O’Toole, John C., Brozinick, Joseph, Hawkins, Eric, Misener, Elizabeth, Briere, Daniel, Brier, Richard A., Wagner, Jill R., Campbell, Robert M., Anderson, Bryan D., Vaughn, Renee, Bennett, Donald B., Meier, Timothy I., Cook, James A.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents
Henry, James R., Li, Yihong, Warshawsky, Alan M., Brozinick, Joseph T., Hawkins, Eric D., Misener, Elizabeth A., Briere, Daniel A., Montrose-Rafizadeh, Chahrzad, Zink, Richard W., Yumibe, Nathan P., Ajamie, Rose T., Wilken, Brad, Devanarayan, Viswanath
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
모듈식 통신 디바이스
RICCIO LUCCA, REPP TIMOTHY CORCORAN, RICCIO MICHAEL, BRIERE DANIEL DEAN
Year of Publication 08.05.2023
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Year of Publication 08.05.2023
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