Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
Liles, W. Conrad, Broxmeyer, Hal E., Rodger, Elin, Wood, Brent, Hübel, Kai, Cooper, Scott, Hangoc, Giao, Bridger, Gary J., Henson, Geoffrey W., Calandra, Gary, Dale, David C.
Published in Blood (15.10.2003)
Published in Blood (15.10.2003)
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Molecular Mechanism of Action of Monocyclam Versus Bicyclam Non-peptide Antagonists in the CXCR4 Chemokine Receptor
Rosenkilde, Mette M., Gerlach, Lars-Ole, Hatse, Sigrid, Skerlj, Renato T., Schols, Dominique, Bridger, Gary J., Schwartz, Thue W.
Published in The Journal of biological chemistry (14.09.2007)
Published in The Journal of biological chemistry (14.09.2007)
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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
Hendrix, Craig W, Collier, Ann C, Lederman, Michael M, Schols, Dominique, Pollard, Richard B, Brown, Stephen, Jackson, J Brooks, Coombs, Robert W, Glesby, Marshall J, Flexner, Charles W, Bridger, Gary J, Badel, Karin, MacFarland, Ronald T, Henson, Geoffrey W, Calandra, Gary
Published in Journal of acquired immune deficiency syndromes (1999) (01.10.2004)
Published in Journal of acquired immune deficiency syndromes (1999) (01.10.2004)
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The molecular pharmacology of AMD11070: An orally bioavailable CXCR4 HIV entry inhibitor
Mosi, Renee M., Anastassova, Virginia, Cox, Jennifer, Darkes, Marilyn C., Idzan, Stefan R., Labrecque, Jean, Lau, Gloria, Nelson, Kim L., Patel, Ketan, Santucci, Zefferino, Wong, Rebecca S.Y., Skerlj, Renato T., Bridger, Gary J., Huskens, Dana, Schols, Dominique, Fricker, Simon P.
Published in Biochemical pharmacology (15.02.2012)
Published in Biochemical pharmacology (15.02.2012)
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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
Hatse, Sigrid, Princen, Katrien, Clercq, Erik De, Rosenkilde, Mette M., Schwartz, Thue W., Hernandez-Abad, Pedro E., Skerlj, Renato T., Bridger, Gary J., Schols, Dominique
Published in Biochemical pharmacology (01.09.2005)
Published in Biochemical pharmacology (01.09.2005)
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Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4
Bodart, Veronique, Anastassov, Virginia, Darkes, Marilyn C., Idzan, Stefan R., Labrecque, Jean, Lau, Gloria, Mosi, Renee M., Neff, Kathleen S., Nelson, Kim L., Ruzek, Melanie C., Patel, Ketan, Santucci, Zefferino, Scarborough, Robert, Wong, Rebecca S.Y., Bridger, Gary J., MacFarland, Ron T., Fricker, Simon P.
Published in Biochemical pharmacology (15.10.2009)
Published in Biochemical pharmacology (15.10.2009)
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Spontaneous Enzymatically Mediated Dynamic Kinetic Resolution of 8-Amino-5,6,7,8-tetrahydroquinoline
Crawford, Jason B, Skerlj, Renato T, Bridger, Gary J
Published in Journal of organic chemistry (19.01.2007)
Published in Journal of organic chemistry (19.01.2007)
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A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome
Badolato, Raffaele, Alsina, Laia, Azar, Antoine, Bertrand, Yves, Bolyard, Audrey A., Dale, David, Deyà-Martínez, Àngela, Dickerson, Kathryn E., Ezra, Navid, Hasle, Henrik, Kang, Hyoung Jin, Kiani-Alikhan, Sorena, Kuijpers, Taco W., Kulagin, Alexander, Langguth, Daman, Levin, Carina, Neth, Olaf, Olbrich, Peter, Peake, Jane, Rodina, Yulia, Rutten, Caroline E., Shcherbina, Anna, Tarrant, Teresa K., Vossen, Matthias G., Wysocki, Christian A., Belschner, Andrea, Bridger, Gary J., Chen, Kelly, Dubuc, Susan, Hu, Yanping, Jiang, Honghua, Li, Sunny, MacLeod, Rick, Stewart, Murray, Taveras, Arthur G., Yan, Tina, Donadieu, Jean
Published in Blood (04.07.2024)
Published in Blood (04.07.2024)
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Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor
HATSE, Sigrid, HUSKENS, Dana, PRMCEN, Katrien, VERMEIRE, Kurt, BRIDGER, Gary J, DE CLERCQ, Erik, ROSENKILDE, Mette M, SCHWARTZ, Thue W, SCHOLS, Dominique
Published in Journal of Virology (01.04.2007)
Published in Journal of Virology (01.04.2007)
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Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication
Skerlj, Renato T, Bridger, Gary J, Kaller, Al, McEachern, Ernest J, Crawford, Jason B, Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor
Rosenkilde, Mette M, Gerlach, Lars-Ole, Jakobsen, Janus S, Skerlj, Renato T, Bridger, Gary J, Schwartz, Thue W
Published in The Journal of biological chemistry (23.01.2004)
Published in The Journal of biological chemistry (23.01.2004)
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Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication
Bridger, Gary J, Skerlj, Renato T, Hernandez-Abad, Pedro E, Bogucki, David E, Wang, Zhongren, Zhou, Yuanxi, Nan, Susan, Boehringer, Eva M, Wilson, Trevor, Crawford, Jason, Metz, Markus, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor
Gerlach, L O, Skerlj, R T, Bridger, G J, Schwartz, T W
Published in The Journal of biological chemistry (27.04.2001)
Published in The Journal of biological chemistry (27.04.2001)
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Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro
Martin, Coralie, Bridger, Gary J., Rankin, Sara M.
Published in British journal of haematology (01.08.2006)
Published in British journal of haematology (01.08.2006)
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HIV - 1 entry inhibition by small - molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high - throughput assay
Labrecque, Jean, Metz, Markus, Lau, Gloria, Darkes, Marilyn C, Wong, Rebecca S.Y, Bogucki, David, Carpenter, Bryon, Chen, Gang, Li, Tongshuang, Nan, Susan, Schols, Dominique, Bridger, Gary J, Fricker, Simon P, Skerlj, Renato T
Published in Virology (New York, N.Y.) (10.05.2011)
Published in Virology (New York, N.Y.) (10.05.2011)
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Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach
Metz, Markus, Bourque, Elyse, Labrecque, Jean, Danthi, Sanjay J, Langille, Jonathan, Harwig, Curtis, Yang, Wen, Darkes, Marilyn C, Lau, Gloria, Santucci, Zefferino, Bridger, Gary J, Schols, Dominique, Fricker, Simon P, Skerlj, Renato T
Published in Journal of the American Chemical Society (19.10.2011)
Published in Journal of the American Chemical Society (19.10.2011)
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