Search Results - "BRIAN W. METCALF" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

by Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Published in British journal of haematology (01.10.2016)

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Journal Article

Target Validation in Drug Discovery

Target Validation in Drug Discovery

by Metcalf, Brian W, Dillon, Susan
Year of Publication 2006

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eBook

COMPOUND FOR MODIFYING HEMOGLOBIN AND USE THEREOF

COMPOUND FOR MODIFYING HEMOGLOBIN AND USE THEREOF

by JASON R HARRIS, LI ZHE, BRIAN W METCALF, XU QING, STEPHEN L GWALTNEY II, CALVIN W YEE
Year of Publication 28.03.2019

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Patent

COMPOUNDS AND USES THEREOF FOR MODULATION OF HEMOGLOBIN

COMPOUNDS AND USES THEREOF FOR MODULATION OF HEMOGLOBIN

by JASON R HARRIS, LI ZHE, XU QING, BRIAN W METCALF, STEPHEN L GWALTNEY II, CALVIN W YEE
Year of Publication 29.11.2018

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Patent

COMPOUNDS AND USES THEREOF FOR MODULATION OF HEMOGLOBIN

COMPOUNDS AND USES THEREOF FOR MODULATION OF HEMOGLOBIN

by JASON R HARRIS, LI ZHE, XU QING, BRIAN W METCALF, STEPHEN L GWALTNEY II, CALVIN W YEE
Year of Publication 29.11.2018

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Patent

cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase

cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase

by Adams, Jerry L, Meek, Thomas D, Mong, Shau Ming, Johnson, Randall K, Metcalf, Brian W
Published in Journal of medicinal chemistry (01.07.1988)

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Journal Article

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

by Meek, Thomas D, Lambert, Dennis M, Dreyer, Geoffrey B, Carr, Thomas J, Tomaszek, Thaddeus A, Moore, Michael L, Strickler, James E, Debouck, Christine, Hyland, Lawrence J, Matthews, Thomas J, Metcalf, Brian W, Petteway, Stephen R
Published in Nature (London) (04.01.1990)

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Journal Article

Inhibition of rat liver steroid 5.alpha.-reductase by 3-androstene-3-carboxylic acids: mechanism of enzyme-inhibitor interaction

Inhibition of rat liver steroid 5.alpha.-reductase by 3-androstene-3-carboxylic acids: mechanism of enzyme-inhibitor interaction

by Levy, Mark A, Brandt, Martin, Heys, J. Richard, Holt, Dennis A, Metcalf, Brian W
Published in Biochemistry (Easton) (20.03.1990)

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Journal Article

alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase

alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase

by Danzin, Charles, Casara, Patrick, Claverie, Nicole, Metcalf, Brian W
Published in Journal of medicinal chemistry (01.01.1981)

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Journal Article

Inhibition of steroid 5.alpha.-reductase by unsaturated 3-carboxy steroids

Inhibition of steroid 5.alpha.-reductase by unsaturated 3-carboxy steroids

by Holt, Dennis A, Levy, Mark A, Oh, Hye Ja, Erb, Jill M, Heaslip, Julie I, Brandt, Martin, Lan-Hargest, Hsuan Yin, Metcalf, Brian W
Published in Journal of medicinal chemistry (01.03.1990)

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Journal Article

An Orally Bioavailable HIV-1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis

An Orally Bioavailable HIV-1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis

by Abdel-Meguid, Sherin S, Metcalf, Brian W, Carr, Thomas J, Demarsh, Peter, DesJarlais, Renee L, Fisher, Seth, Green, David W, Ivanoff, Lucinda, Lambert, Dennis M
Published in Biochemistry (Easton) (04.10.1994)

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Journal Article

Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere

Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere

by Thompson, Scott K., Eppley, Alecia M., Frazee, James S., Darcy, Michael G., Lum, Robert T., Tomaszek, Thaddeus A., Ivanoff, Lucinda A., Morris, Jane F., Sternberg, Edmund J., Lambert, Dennis M., Fernandez, Annabellee V., Petteway, Stephen R., Meek, Thomas D, Metcalf, Brian W., Gleason, John G.
Published in Bioorganic & medicinal chemistry letters (01.10.1994)

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Journal Article

GBT 440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

GBT 440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

by Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Published in British journal of haematology (01.10.2016)

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Journal Article

A stereospecific total synthesis of racemic 11.alpha.-hydroxyprogesterone via a biomimetic polyene cyclization

A stereospecific total synthesis of racemic 11.alpha.-hydroxyprogesterone via a biomimetic polyene cyclization

by Johnson, William S, Escher, Sina, Metcalf, Brian W
Published in Journal of the American Chemical Society (01.02.1976)

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Journal Article

Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease

Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease

by Tomaszek, Thaddeus A, Moore, Michael L, Strickler, James E, Sanchez, Robert L, Dixon, J. Scott, Metcalf, Brian W, Hassell, Anne, Dreyer, Geoffrey B, Brooks, Isobel
Published in Biochemistry (Easton) (27.10.1992)

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Journal Article

Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

by Louis-Flamberg, Pearl, Peishoff, Catherine E, Bryan, Deborah L, Leber, Jack, Elliott, John D, Metcalf, Brian W, Mayer, Ruth J
Published in Biochemistry (Easton) (01.05.1990)

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Journal Article

Correction: Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Erratum to document cited in CA112(23):212921g]

Correction: Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Erratum to document cited in CA112(23):212921g]

by Louis-Flamberg, Pearl, Peishoff, Catherine E, Bryan, Deborah L, Leber, Jack, Elliott, John D, Metcalf, Brian W, Mayer, Ruth J
Published in Biochemistry (Easton) (01.08.1990)

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Journal Article

4-Amino-4,5-dihydrothiophene-2-carboxylic acid

4-Amino-4,5-dihydrothiophene-2-carboxylic acid

by Adams, Jerry L, Chen, Teng Man, Metcalf, Brian W
Published in Journal of organic chemistry (01.07.1985)

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Journal Article

THE PHOTOCHEMICAL-REARRANGEMENT OF A STEROIDAL DIENOL TRIFLATE

THE PHOTOCHEMICAL-REARRANGEMENT OF A STEROIDAL DIENOL TRIFLATE

by LANHARGEST, HY, ELLIOTT, JD, EGGLESTON, DS, METCALF, BW
Published in Tetrahedron letters (01.01.1987)

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Journal Article

Steroidal A ring aryl carboxylic acids: a new class of steroid 5.alpha.-reductase inhibitors

Steroidal A ring aryl carboxylic acids: a new class of steroid 5.alpha.-reductase inhibitors

by Holt, Dennis A, Levy, Mark A, Ladd, David L, Oh, Hye Ja, Erb, Jill M, Heaslip, Julie I, Brandt, Martin, Metcalf, Brian W
Published in Journal of medicinal chemistry (01.03.1990)

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Journal Article

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