Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published in Nature communications (02.07.2015)
Published in Nature communications (02.07.2015)
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Journal Article
Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Journal Article
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Journal Article
HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF
BENOIT MOREAU, RICHARD WOOSTER, BRIAN H WHITE, SUDHAKAR KADIYALA, MARK T BILODEAU
Year of Publication 30.07.2024
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Year of Publication 30.07.2024
Patent
CONJUGATE FOR DRUG DELIVERY
BENOIT MOREAU, RICHARD WOOSTER, BRIAN H WHITE, TIMOTHY EDWARD BARDER, SUDHAKAR KADIYALA, RAJESH R SHINDE, MARK T BILODEAU
Year of Publication 15.06.2017
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Year of Publication 15.06.2017
Patent
Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 3094: Discovery of a HeliconTM peptide inhibitor of the beta-catenin-TCF interaction with in vivo activity
White, Brian H., Si, Yaguang, Cappucci, Sarah, Li, Zhi, Ramirez, Jessica D., Ponthier, Charles M., Visness, Erica, Du, Peicheng, Choi, Minjung, Beerepoot, Pieter C., Ortet, Paula C., Jewett, Ivan T., Alfaro-Lopez, Josue, Agarwal, Sorabh, La, Daniel, Fulgham, Aaron, McGee, John H., Orford, Keith, Hurov, Jonathan B., Tremblay, Martin R., Verdine, Gregory L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF
Bilodeau, Mark T, White, Brian H, Shinde, Rajesh R, Moreau, Benoît, Wooster, Richard, Kadiyala, Sudhakar
Year of Publication 15.09.2022
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Year of Publication 15.09.2022
Patent