Search Results - "BRIAN EASTMAN" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

by Tam, Betty Y., Chiu, Kevin, Chung, Heekyung, Bossard, Carine, Nguyen, John Duc, Creger, Emily, Eastman, Brian W., Mak, Chi Ching, Ibanez, Maureen, Ghias, Abdullah, Cahiwat, Joseph, Do, Long, Cho, Shawn, Nguyen, Jackie, Deshmukh, Vishal, Stewart, Josh, Chen, Chiao-Wen, Barroga, Charlene, Dellamary, Luis, KC, Sunil K., Phalen, Timothy J., Hood, John, Cha, Steven, Yazici, Yusuf
Published in Cancer letters (31.03.2020)

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Journal Article

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

by Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T
Published in Journal of medicinal chemistry (16.01.2003)

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Journal Article

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors

by White, Alex W., Curtin, Nicola J., Eastman, Brian W., Golding, Bernard T., Hostomsky, Zdenek, Kyle, Suzanne, Li, Jianke, Maegley, Karen A., Skalitzky, Donald J., Webber, Stephen E., Yu, Xiao-Hong, Griffin, Roger J.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)

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Journal Article

3-[3-Fluoro-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

3-[3-Fluoro-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

by Poon, Steve F., Eastman, Brian W., Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Holtz, Gregory, Cosford, Nicholas D.P., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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Journal Article

Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease

Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease

by Johnson, Theodore O, Hua, Ye, Luu, Hiep T, Brown, Edward L, Chan, Fora, Chu, Shao Song, Dragovich, Peter S, Eastman, Brian W, Ferre, Rose Ann, Fuhrman, Shella A, Hendrickson, Thomas F, Maldonado, Fausto C, Matthews, David A, Meador, James W, Patick, Amy K, Reich, Siegfried H, Skalitzky, Donald J, Worland, Stephen T, Yang, Michelle, Zalman, Leora S
Published in Journal of medicinal chemistry (09.05.2002)

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Journal Article

The Pan-Clk/Dyrk Inhibitor Cirtuvivint (SM08502) Exposes Mechanistic Underpinnings of Alternative Splicing As a Therapeutic Vulnerability in Heme Malignancies

The Pan-Clk/Dyrk Inhibitor Cirtuvivint (SM08502) Exposes Mechanistic Underpinnings of Alternative Splicing As a Therapeutic Vulnerability in Heme Malignancies

by Bossard, Carine, McMillan, Elizabeth A., Creger, Emily, Eastman, Brian, Mak, Chi-Ching, Beaupre, Darrin M., White, Michael A.
Published in Blood (23.11.2021)

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Journal Article

Abstract P250: Evaluation of systemic pan-CLK/DYRK inhibition on organ function and tissue self-renewal

Abstract P250: Evaluation of systemic pan-CLK/DYRK inhibition on organ function and tissue self-renewal

by Falahatpisheh, Hadi, Dehghani, Maryam, Morrow, Jane, Tsao, Catherine, Dorrow, Steven, Stewart, Josh, Bossard, Carine, Eastman, Brian, Mak, Chi-Ching, Pandher, Karamjeet, White, Michael A.
Published in Molecular cancer therapeutics (01.12.2021)

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Journal Article

Abstract P242: Preclinical efficacy landscape of the pan-CLK/DYRK inhibitor Cirtuvivint (SM08502)

Abstract P242: Preclinical efficacy landscape of the pan-CLK/DYRK inhibitor Cirtuvivint (SM08502)

by Bossard, Carine, Creger, Emily, McMillan, Elizabeth A., Merkwirth, Carsten, Ibanez, Maureen, Bhat, Deepti, Stewart, Josh, Eastman, Brian, Mak, Chi-Ching, Deshmukh, Vishal, White, Michael A.
Published in Molecular cancer therapeutics (01.12.2021)

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Journal Article

Abstract C08: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates activity against cancer stem cell (CSC)-enriched pancreatic cancer cells and suppresses stemness in vitro

Abstract C08: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates activity against cancer stem cell (CSC)-enriched pancreatic cancer cells and suppresses stemness in vitro

by Bossard, Carine, Cruz, Nathalia, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.12.2019)

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Journal Article

Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models

Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models

by Chung, Heekyung, Sitts, Lauren, Wu, Chu-Chiao, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Stewart, Josh, Bossard, Carine, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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Journal Article

Abstract 5691: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt pathway inhibition in castration-resistant prostate cancer (CRPC) models

Abstract 5691: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt pathway inhibition in castration-resistant prostate cancer (CRPC) models

by Bossard, Carine, Cruz, Nathalia, Chiu, Kevin, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Bucci, Gail, Stewart, Josh, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)

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Journal Article

Abstract A09: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects in diverse ovarian cancer models

Abstract A09: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects in diverse ovarian cancer models

by Chung, Heekyung, Sitts, Lauren, Creger, Emily, Liao, Erica, Eastman, Brian, Mak, Chi-Ching, Sunil, K.C., Tam, Betty, Bucci, Gail, Stewart, Josh, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Clinical cancer research (01.07.2020)

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Journal Article

Abstract P3-13-01: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects as monotherapy and in combination with chemotherapy in triple-negative breast cancer (TNBC) models

Abstract P3-13-01: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects as monotherapy and in combination with chemotherapy in triple-negative breast cancer (TNBC) models

by Chung, Heekyung, Sitts, Lauren, Creger, Emily, Nguyen, John Duc, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.02.2020)

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Journal Article

Abstract A02: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, downregulates the Wnt signaling pathway and demonstrates antitumor activity in pancreatic cancer cell lines and in vivo xenograft models

Abstract A02: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, downregulates the Wnt signaling pathway and demonstrates antitumor activity in pancreatic cancer cell lines and in vivo xenograft models

by Bossard, Carine, Cruz, Nathalia, Eastman, Brian, Mak, Chi-Ching, Sunil, K.C., Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.12.2019)

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Journal Article

Abstract C09: Inhibition of tumor growth and post-treatment regrowth by SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, in combination with standard of care in pancreatic cancer models

Abstract C09: Inhibition of tumor growth and post-treatment regrowth by SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, in combination with standard of care in pancreatic cancer models

by Bossard, Carine, Astsaturov, Igor, Cruz, Nathalia, Eastman, Brian, Mak, Chi-Ching, Sunil, K.C., Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.12.2019)

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Journal Article

Effects of SM08502, a novel, oral small-molecule inhibitor of Wnt pathway signaling, on gene expression and antitumor activity in colorectal cancer (CRC) models

Effects of SM08502, a novel, oral small-molecule inhibitor of Wnt pathway signaling, on gene expression and antitumor activity in colorectal cancer (CRC) models

by Bossard, Carine, Chiu, Kevin, Chung, Heekyung, Nguyen, John Duc, Creger, Emily, Eastman, Brian, Mak, Chi Ching, Do, Long, Cho, Shawn, KC, Sunil, Phalen, Timothy, Tambiah, Jeyanesh, Cha, Steven
Published in Journal of clinical oncology (20.05.2019)

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Journal Article

Abstract 3928: The pan-CLK/DYRK inhibitor cirtuvivint selectively disrupts alternative splicing and has broad anti-tumor activity in preclinical models

Abstract 3928: The pan-CLK/DYRK inhibitor cirtuvivint selectively disrupts alternative splicing and has broad anti-tumor activity in preclinical models

by McMillan, Elizabeth A., Bossard, Carine, Creger, Emily, Merkwirth, Carsten, Pippa, Raffaella, Jarvis, Matthew, Sriram, Krishna, Pedraza, Melinda, Ibanez, Maureen, Bhat, Deepti, Lai, Carolyn, Stewart, Josh, Eastman, Brian, Mak, Chi-Ching, White, Michael A., Beaupre, Darrin
Published in Cancer research (Chicago, Ill.) (15.06.2022)

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Journal Article

Sterile drape for a surgical display and method related thereto

Sterile drape for a surgical display and method related thereto

by Gerg, James, Eastman, Brian
Year of Publication 12.04.2022

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Patent

STERILE DRAPE FOR A SURGICAL DISPLAY AND METHOD RELATED THERETO

STERILE DRAPE FOR A SURGICAL DISPLAY AND METHOD RELATED THERETO

by GERG, James, EASTMAN, Brian
Year of Publication 13.05.2020

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Patent

WORK VEHICLE AND METHOD FOR PROVIDING TRACTION CONTROL IN A WORK VEHICLE

WORK VEHICLE AND METHOD FOR PROVIDING TRACTION CONTROL IN A WORK VEHICLE

by EASTMAN BRIAN T
Year of Publication 08.08.2023

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Patent

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