A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors
Moores, Sheri L, Chiu, Mark L, Bushey, Barbara S, Chevalier, Kristen, Luistro, Leopoldo, Dorn, Keri, Brezski, Randall J, Haytko, Peter, Kelly, Thomas, Wu, Sheng-Jiun, Martin, Pauline L, Neijssen, Joost, Parren, Paul W H I, Schuurman, Janine, Attar, Ricardo M, Laquerre, Sylvie, Lorenzi, Matthew V, Anderson, G Mark
Published in Cancer research (Chicago, Ill.) (01.07.2016)
Published in Cancer research (Chicago, Ill.) (01.07.2016)
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Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages
Shi, Yun, Fan, Xuejun, Deng, Hui, Brezski, Randall J, Rycyzyn, Michael, Jordan, Robert E, Strohl, William R, Zou, Quanming, Zhang, Ningyan, An, Zhiqiang
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.
Published in The Journal of biological chemistry (03.03.2017)
Published in The Journal of biological chemistry (03.03.2017)
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An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
Vafa, Omid, Gilliland, Gary L., Brezski, Randall J., Strake, Brandy, Wilkinson, Teresa, Lacy, Eilyn R., Scallon, Bernard, Teplyakov, Alexey, Malia, Thomas J., Strohl, William R.
Published in Methods (San Diego, Calif.) (01.01.2014)
Published in Methods (San Diego, Calif.) (01.01.2014)
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Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease
Biancheri, Paolo, Brezski, Randall J, Di Sabatino, Antonio, Greenplate, Allison R, Soring, Keri L, Corazza, Gino R, Kok, Klaartje B, Rovedatti, Laura, Vossenkämper, Anna, Ahmad, Nadja, Snoek, Susanne A, Vermeire, Severine, Rutgeerts, Paul, Jordan, Robert E, MacDonald, Thomas T
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2015)
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Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes
Gupta, Nidhi, Wang, Xinhua, Wen, Xiaohui, Moran, Paul, Paluch, Maciej, Hass, Philip E, Heidersbach, Amy, Haley, Benjamin, Kirchhofer, Daniel, Brezski, Randall J, Peterson, Andrew S, Scales, Suzie J
Published in Journal of the American Society of Nephrology (01.09.2020)
Published in Journal of the American Society of Nephrology (01.09.2020)
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Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections
Buckley, Peter T., Chan, Rita, Fernandez, Jeffrey, Luo, Jinquan, Lacey, Keenan A., DuMont, Ashley L., O’Malley, Aidan, Brezski, Randall J., Zheng, Songmao, Malia, Thomas, Whitaker, Brian, Zwolak, Adam, Payne, Angela, Clark, Desmond, Sigg, Martin, Lacy, Eilyn R., Kornilova, Anna, Kwok, Debra, McCarthy, Steve, Wu, Bingyuan, Morrow, Brian, Nemeth-Seay, Jennifer, Petley, Ted, Wu, Sam, Strohl, William R., Lynch, Anthony Simon, Torres, Victor J.
Published in Cell host & microbe (10.05.2023)
Published in Cell host & microbe (10.05.2023)
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Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function
Grugan, Katharine D, McCabe, Francis L, Kinder, Michelle, Greenplate, Allison R, Harman, Benjamin C, Ekert, Jason E, van Rooijen, Nico, Anderson, G Mark, Nemeth, Jeffrey A, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Published in The Journal of immunology (1950) (01.12.2012)
Published in The Journal of immunology (1950) (01.12.2012)
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Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling
Treml, Laura S, Quinn III, William J, Kaileh, Mary, Scholz, Jean L, Cancro, Michael P, Jordan, Kimberly A, Karnell, Fredrick G, Monroe, John G, Stadanlick, Jason E, Sen, Ranjan, Miller, Juli P, Brezski, Randall J
Published in Nature immunology (01.12.2008)
Published in Nature immunology (01.12.2008)
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Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells
Huang, Tao, Mathieu, Mary, Lee, Sophia, Wang, Xinhua, Kee, Yee Seir, Bevers, Jack J., Ciferri, Claudio, Estavez, Alberto, Wong, Manda, Chiang, Nancy Y., Nakamura, Gerald, Brezski, Randall J.
Published in The Journal of biological chemistry (19.01.2018)
Published in The Journal of biological chemistry (19.01.2018)
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Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity
Zhang, Ningyan, Deng, Hui, Fan, Xuejun, Gonzalez, Anneliese, Zhang, Songlin, Brezski, Randall J, Choi, Byung-Kwon, Rycyzyn, Michael, Strohl, William, Jordan, Robert, An, Zhiqiang
Published in Clinical cancer research (01.12.2015)
Published in Clinical cancer research (01.12.2015)
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yang, Yanli, Yeh, Sherry H, Madireddi, Shravan, Matochko, Wadim L, Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F, Leonard, Brandon, Scales, Suzie J, Zhu, Jing W, Christensen, Erin, Hang, Julie Q, Brezski, Randall J, Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M, Lazar, Greg A
Published in mAbs (18.08.2019)
Published in mAbs (18.08.2019)
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A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy
Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Published in Breast cancer research : BCR (08.08.2012)
Published in Breast cancer research : BCR (08.08.2012)
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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
Brezski, Randall J, Vafa, Omid, Petrone, Diane, Tam, Susan H, Powers, Gordon, Ryan, Mary H, Luongo, Jennifer L, Oberholtzer, Allison, Knight, David M, Jordan, Robert E
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (20.10.2009)
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A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies
Fan, Xuejun, Brezski, Randall J, Deng, Hui, Dhupkar, Pooja M, Shi, Yun, Gonzalez, Anneliese, Zhang, Songlin, Rycyzyn, Michael, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
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Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge
Malia, Thomas J., Teplyakov, Alexey, Brezski, Randall J., Luo, Jinquan, Kinder, Michelle, Sweet, Raymond W., Almagro, Juan C., Jordan, Robert E., Gilliland, Gary L.
Published in Proteins, structure, function, and bioinformatics (01.08.2014)
Published in Proteins, structure, function, and bioinformatics (01.08.2014)
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