Comparative transcriptomic analysis validates iPSC derived in-vitro progressive fibrosis model as a screening tool for drug discovery and development in systemic sclerosis
Nathan, Shyam, Wang, Yifei, D’ambrosio, Matthew, Paul, Reeba, Lyu, Huimin, Delic, Denis, Bretschneider, Tom, Falana, Kimberly, Li, Li, Vijayaraj, Preethi
Published in Scientific reports (18.10.2024)
Published in Scientific reports (18.10.2024)
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Journal Article
Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen
Graupner, Katharina, Scherlach, Kirstin, Bretschneider, Tom, Lackner, Gerald, Roth, Martin, Gross, Harald, Hertweck, Christian
Published in Angewandte Chemie International Edition (21.12.2012)
Published in Angewandte Chemie International Edition (21.12.2012)
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Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
Schruf, Eva, Schroeder, Victoria, Kuttruff, Christian A, Weigle, Sabine, Krell, Martin, Benz, Maryke, Bretschneider, Tom, Holweg, Alexander, Schuler, Michael, Frick, Manfred, Nicklin, Paul, Garnett, James P, Sobotta, Mirko C
Published in Respiratory research (09.05.2019)
Published in Respiratory research (09.05.2019)
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Phenalenone-type phytoalexins mediate resistance of banana plants (Musa spp.) to the burrowing nematode Radopholus similis
Hölscher, Dirk, Dhakshinamoorthy, Suganthagunthalam, Alexandrov, Theodore, Becker, Michael, Bretschneider, Tom, Buerkert, Andreas, Crecelius, Anna C., Waele, Dirk De, Elsen, Annemie, Heckel, David G., Heklau, Heike, Hertweck, Christian, Kai, Marco, Knop, Katrin, Krafft, Christoph, Maddula, Ravi K., Matthäus, Christian, Popp, Jürgen, Schneider, Bernd, Schubert, Ulrich S., Sikora, Richard A., Svatoš, Aleš, Swennen, Rony L.
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
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Journal Article
A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis
Bretschneider, Tom, Zocher, Georg, Unger, Michelle, Scherlach, Kirstin, Stehle, Thilo, Hertweck, Christian
Published in Nature chemical biology (18.12.2011)
Published in Nature chemical biology (18.12.2011)
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Journal Article
Mapping the metabolomic and lipidomic changes in the bleomycin model of pulmonary fibrosis in young and aged mice
Weckerle, Jelena, Picart-Armada, Sergio, Klee, Stephan, Bretschneider, Tom, Luippold, Andreas H, Rist, Wolfgang, Haslinger, Christian, Schlüter, Holger, Thomas, Matthew J, Krawczyk, Bartlomiej, Fernandez-Albert, Francesc, Kästle, Marc, Veyel, Daniel
Published in Disease models & mechanisms (01.01.2022)
Published in Disease models & mechanisms (01.01.2022)
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Journal Article
Synthetic Remodeling of the Chartreusin Pathway to Tune Antiproliferative and Antibacterial Activities
Ueberschaar, Nico, Xu, Zhongli, Scherlach, Kirstin, Metsä-Ketelä, Mikko, Bretschneider, Tom, Dahse, Hans-Martin, Görls, Helmar, Hertweck, Christian
Published in Journal of the American Chemical Society (20.11.2013)
Published in Journal of the American Chemical Society (20.11.2013)
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Journal Article
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors
Winter, Martin, Simon, Roman P., Wang, Yuting, Bretschneider, Tom, Bauer, Margit, Magarkar, Aniket, Reindl, Wolfgang, Fernández-Montalván, Amaury, Montel, Florian, Büttner, Frank H.
Published in SLAS discovery (01.07.2022)
Published in SLAS discovery (01.07.2022)
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Journal Article
Vinylogous chain branching catalysed by a dedicated polyketide synthase module
Bretschneider, Tom, Heim, Joel B., Heine, Daniel, Winkler, Robert, Busch, Benjamin, Kusebauch, Björn, Stehle, Thilo, Zocher, Georg, Hertweck, Christian
Published in Nature (London) (03.10.2013)
Published in Nature (London) (03.10.2013)
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Journal Article
Biomarker discovery for chronic liver diseases by multi-omics – a preclinical case study
Veyel, Daniel, Wenger, Kathrin, Broermann, Andre, Bretschneider, Tom, Luippold, Andreas H., Krawczyk, Bartlomiej, Rist, Wolfgang, Simon, Eric
Published in Scientific reports (28.01.2020)
Published in Scientific reports (28.01.2020)
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Journal Article
Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
Jones, Amanda K, Chen, Hongxing, Ng, Khing Jow, Villalona, Jorge, McHugh, Mark, Zeveleva, Svetlana, Wilks, James, Brilisauer, Klaus, Bretschneider, Tom, Qian, Hu Sheng, Fryer, Ryan M
Published in The Journal of pharmacology and experimental therapeutics (01.07.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2023)
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Journal Article
Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions
Münster, Alexandra, Sommer, Susanne, Kúkeľová, Diana, Sigrist, Hannes, Koros, Eliza, Deiana, Serena, Klinder, Klaus, Baader-Pagler, Tamara, Mayer-Wrangowski, Svenja, Ferger, Boris, Bretschneider, Tom, Pryce, Christopher R., Hauber, Wolfgang, von Heimendahl, Moritz
Published in Neuropharmacology (01.08.2022)
Published in Neuropharmacology (01.08.2022)
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Journal Article
Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
Kuttruff, Christian A., Fleck, Martin, Carotta, Sebastian, Arnhof, Heribert, Bretschneider, Tom, Dahmann, Georg, Gremel, Gabriela, Grube, Achim, Handschuh, Sandra, Heimann, Annekatrin, Hofmann, Marco H., Impagnatiello, Maria A., Nar, Herbert, Rast, Georg, Schaaf, Otmar, Schmidt, Esther, Oost, Thorsten
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice
Weckerle, Jelena, Mayr, Christoph H, Fundel-Clemens, Katrin, Lämmle, Bärbel, Boryn, Lukasz, Thomas, Matthew J, Bretschneider, Tom, Luippold, Andreas H, Huber, Heinrich J, Viollet, Coralie, Rist, Wolfgang, Veyel, Daniel, Ramirez, Fidel, Klee, Stephan, Kästle, Marc
Published in American journal of respiratory cell and molecular biology (01.10.2023)
Published in American journal of respiratory cell and molecular biology (01.10.2023)
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Journal Article
Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis
Baader, Manuel, Bretschneider, Tom, Broermann, Andre, Rippmann, Joerg F, Stierstorfer, Birgit, Kuttruff, Christian A, Mark, Michael
Published in British journal of pharmacology (01.02.2018)
Published in British journal of pharmacology (01.02.2018)
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Journal Article
Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI‑3231, a Well-Characterized Chemical Probe Available for Open Science
Thamm, Sven, Willwacher, Marina K., Aspnes, Gary E., Bretschneider, Tom, Brown, Nicholas F., Buschbom-Helmke, Silke, Fox, Thomas, Gargano, Emanuele M., Grabowski, Daniel, Hoenke, Christoph, Matera, Damian, Mueck, Katja, Peters, Stefan, Reindl, Sophia, Riether, Doris, Schmid, Matthias, Tautermann, Christofer S., Teitelbaum, Aaron M., Trünkle, Cornelius, Veser, Thomas, Winter, Martin, Wortmann, Lars
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Journal Article
Biosynthesis and Mass Spectrometric Imaging of Tolaasin, the Virulence Factor of Brown Blotch Mushroom Disease
Scherlach, Kirstin, Lackner, Gerald, Graupner, Katharina, Pidot, Sacha, Bretschneider, Tom, Hertweck, Christian
Published in Chembiochem : a European journal of chemical biology (16.12.2013)
Published in Chembiochem : a European journal of chemical biology (16.12.2013)
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