Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Hong, Chuan, Byrne, Noel J., Zamlynny, Beata, Tummala, Srivanya, Xiao, Li, Shipman, Jennifer M., Partridge, Andrea T., Minnick, Christina, Breslin, Michael J., Rudd, Michael T., Stachel, Shawn J., Rada, Vanessa L., Kern, Jeffrey C., Armacost, Kira A., Hollingsworth, Scott A., O’Brien, Julie A., Hall, Dawn L., McDonald, Terrence P., Strickland, Corey, Brooun, Alexei, Soisson, Stephen M., Hollenstein, Kaspar
Published in Nature communications (05.02.2021)
Published in Nature communications (05.02.2021)
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Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Vardigan, Joshua D, Pall, Parul S, McDevitt, Dillon S, Huang, ChienJung, Clements, Michelle K, Li, Yuxing, Kraus, Richard L, Breslin, Michael J, Bungard, Christopher J, Nemenov, Mikhail I, Klukinov, Mikhail, Burgey, Chritopher S, Layton, Mark E, Stachel, Shawn J, Lange, Henry S, Savitz, Alan T, Santarelli, Vincent P, Henze, Darrell A, Uslaner, Jason M
Published in Pain (Amsterdam) (08.10.2024)
Published in Pain (Amsterdam) (08.10.2024)
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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Tannenbaum, Pamela L., Garson, Susan L., Doran, Scott M., Breslin, Michael J., Schreier, John D., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Neuropharmacology (01.02.2012)
Published in Neuropharmacology (01.02.2012)
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2-Aminopyridines as Potent and Selective Na v 1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J, Schubert, Jeffrey W, Wang, Deping, Huang, Chienjung, Clements, Michelle K, Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D, Kraus, Richard L, Santarelli, Vincent P, Uslaner, Jason M, Coleman, Paul J, Stachel, Shawn J
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Journal Article
2‑Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J., Schubert, Jeffrey W., Wang, Deping, Huang, Chienjung, Clements, Michelle K., Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D., Kraus, Richard L., Santarelli, Vincent P., Uslaner, Jason M., Coleman, Paul J., Stachel, Shawn J.
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Examining the relationship between schizotypy and religious experience among Irish adults
Breslin, Michael J., Lewis, Christopher Alan
Published in Mental health, religion & culture (21.04.2017)
Published in Mental health, religion & culture (21.04.2017)
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Journal Article
Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist
Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.
Published in Journal of neurogenetics (01.03.2011)
Published in Journal of neurogenetics (01.03.2011)
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Journal Article
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey
Smith, Sean M., Uslaner, Jason M., Cox, Christopher D., Huszar, Sarah L., Cannon, Christopher E., Vardigan, Joshua D., Eddins, Donnie, Toolan, Dawn M., Kandebo, Monika, Yao, Lihang, Raheem, Izzat T., Schreier, John D., Breslin, Michael J., Coleman, Paul J., Renger, John J.
Published in Neuropharmacology (01.01.2013)
Published in Neuropharmacology (01.01.2013)
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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D, Coleman, Paul J, Breslin, Michael J, Whitman, David B, Garbaccio, Robert M, Fraley, Mark E, Buser, Carolyn A, Walsh, Eileen S, Hamilton, Kelly, Schaber, Michael D, Lobell, Robert B, Tao, Weikang, Davide, Joseph P, Diehl, Ronald E, Abrams, Marc T, South, Vicki J, Huber, Hans E, Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E, Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C, Kohl, Nancy E, Hartman, George D
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Journal Article
Psychometric Properties of Three Measures of “Facebook Engagement and/or Addiction” Among a Sample of English-Speaking Pakistani University Students
Turley, Joanne, Lewis, Christopher Alan, Musharraf, Sadia, Malik, Jamil A., Breslin, Michael J.
Published in International journal of mental health and addiction (01.08.2019)
Published in International journal of mental health and addiction (01.08.2019)
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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran, H. Marie, Schirripa, Kathy M., Roecker, Anthony J., Breslin, Michael J., Tong, Ling, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Newman, Justin A., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.
Published in ACS medicinal chemistry letters (11.01.2024)
Published in ACS medicinal chemistry letters (11.01.2024)
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Journal Article
Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Breslin, Michael J., Whitman, David B., Bogusky, Michael J., McGaughey, Georgia B., Bednar, Rodney A., Lemaire, Wei, Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Harrell, C. Meacham, Reiss, Duane R., Cabalu, Tamara D., Cui, Donghui, Prueksaritanont, Thomayant, Stevens, Joanne, Tannenbaum, Pamela L., Ball, Richard G., Stellabott, Joyce, Young, Steven D., Hartman, George D., Winrow, Christopher J., Renger, John J.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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Journal Article
Eysenck's model of personality and prayer: the utility of a multidimensional approach
Breslin, Michael J., Lewis, Christopher Alan
Published in Mental health, religion & culture (16.03.2014)
Published in Mental health, religion & culture (16.03.2014)
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Journal Article
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant
Raheem, Izzat T., Breslin, Michael J., Bruno, Joseph, Cabalu, Tamara D., Cooke, Andrew, Cox, Christopher D., Cui, Donghui, Garson, Susan, Gotter, Anthony L., Fox, Steven V., Harrell, C. Meacham, Kuduk, Scott D., Lemaire, Wei, Prueksaritanont, Thomayant, Renger, John J., Stump, Craig, Tannenbaum, Pamela L., Williams, Peter D., Winrow, Christopher J., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Cox, Christopher D., Breslin, Michael J., Mariano, Brenda J., Coleman, Paul J., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Huber, Hans E., Kohl, Nancy E., Torrent, Maricel, Yan, Youwei, Kuo, Laurence C., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Raheem, Izzat T., Breslin, Michael J., Fandozzi, Christine, Fuerst, Joy, Hill, Nicole, Huszar, Sarah, Kandebo, Monika, Kim, Somang H., Ma, Bennett, McGaughey, Georgia, Renger, John J., Schreier, John D., Sharma, Sujata, Smith, Sean, Uslaner, Jason, Yan, Youwei, Coleman, Paul J., Cox, Christopher D.
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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Journal Article
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
Cox, Christopher D, Breslin, Michael J, Whitman, David B, Schreier, John D, McGaughey, Georgia B, Bogusky, Michael J, Roecker, Anthony J, Mercer, Swati P, Bednar, Rodney A, Lemaire, Wei, Bruno, Joseph G, Reiss, Duane R, Harrell, C. Meacham, Murphy, Kathy L, Garson, Susan L, Doran, Scott M, Prueksaritanont, Thomayant, Anderson, Wayne B, Tang, Cuyue, Roller, Shane, Cabalu, Tamara D, Cui, Donghui, Hartman, George D, Young, Steven D, Koblan, Ken S, Winrow, Christopher J, Renger, John J, Coleman, Paul J
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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Journal Article
Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs
McGaughey, Georgia, Bayly, Christopher I., Cox, Christopher D., Schreier, John D., Breslin, Michael J., Bogusky, Michael, Pitzenberger, Steve, Ball, Richard, Coleman, Paul J.
Published in Journal of computer-aided molecular design (2014)
Published in Journal of computer-aided molecular design (2014)
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Journal Article
Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
Whitman, David B., Cox, Christopher D., Breslin, Michael J., Brashear, Karen M., Schreier, John D., Bogusky, Michael J., Bednar, Rodney A., Lemaire, Wei, Bruno, Joseph G., Hartman, George D., Reiss , Duane R., Harrell, C. Meacham, Kraus, Richard L., Li, Yuxing, Garson, Susan L., Doran, Scott M., Prueksaritanont, Thomayant, Li, Chunze, Winrow, Christopher J., Koblan, Kenneth S., Renger, John J., Coleman, Paul J.
Published in ChemMedChem (06.07.2009)
Published in ChemMedChem (06.07.2009)
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