Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening
Turcano, Lorenzo, Torrente, Esther, Missineo, Antonino, Andreini, Matteo, Gramiccia, Marina, Di Muccio, Trentina, Genovese, Ilaria, Fiorillo, Annarita, Harper, Steven, Bresciani, Alberto, Colotti, Gianni, Ilari, Andrea
Published in PLoS neglected tropical diseases (01.11.2018)
Published in PLoS neglected tropical diseases (01.11.2018)
Get full text
Journal Article
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
Scagliola, Alessandra, Miluzio, Annarita, Ventura, Gabriele, Oliveto, Stefania, Cordiglieri, Chiara, Manfrini, Nicola, Cirino, Delia, Ricciardi, Sara, Valenti, Luca, Baselli, Guido, D’Ambrosio, Roberta, Maggioni, Marco, Brina, Daniela, Bresciani, Alberto, Biffo, Stefano
Published in Nature communications (12.08.2021)
Published in Nature communications (12.08.2021)
Get full text
Journal Article
Quantifying autophagy using novel LC3B and p62 TR-FRET assays
Bresciani, Alberto, Spiezia, Maria Carolina, Boggio, Roberto, Cariulo, Cristina, Nordheim, Anja, Altobelli, Roberta, Kuhlbrodt, Kirsten, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Wityak, John, Fodale, Valentina, Marchionini, Deanna M, Weiss, Andreas
Published in PloS one (19.03.2018)
Published in PloS one (19.03.2018)
Get full text
Journal Article
Salivary Huntingtin protein is uniquely associated with clinical features of Huntington’s disease
Parkin, Georgia M., Corey-Bloom, Jody, Snell, Chase, Smith, Haileigh, Laurenza, Angela, Daldin, Manuel, Bresciani, Alberto, Thomas, Elizabeth A.
Published in Scientific reports (19.01.2023)
Published in Scientific reports (19.01.2023)
Get full text
Journal Article
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease
Vezzoli, Elena, Caron, Ilaria, Talpo, Francesca, Besusso, Dario, Conforti, Paola, Battaglia, Elisa, Sogne, Elisa, Falqui, Andrea, Petricca, Lara, Verani, Margherita, Martufi, Paola, Caricasole, Andrea, Bresciani, Alberto, Cecchetti, Ottavia, Rivetti di Val Cervo, Pia, Sancini, Giulio, Riess, Olaf, Nguyen, Hoa, Seipold, Lisa, Saftig, Paul, Biella, Gerardo, Cattaneo, Elena, Zuccato, Chiara
Published in The Journal of clinical investigation (01.06.2019)
Published in The Journal of clinical investigation (01.06.2019)
Get full text
Journal Article
Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
Fodale, Valentina, Pintauro, Roberta, Daldin, Manuel, Altobelli, Roberta, Spiezia, Maria Carolina, Bisbocci, Monica, Macdonald, Douglas, Bresciani, Alberto
Published in Scientific reports (17.12.2020)
Published in Scientific reports (17.12.2020)
Get full text
Journal Article
Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni
Lalli, Cristiana, Guidi, Alessandra, Gennari, Nadia, Altamura, Sergio, Bresciani, Alberto, Ruberti, Giovina
Published in PLoS neglected tropical diseases (01.01.2015)
Published in PLoS neglected tropical diseases (01.01.2015)
Get full text
Journal Article
Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production
Guidi, Alessandra, Lalli, Cristiana, Gimmelli, Roberto, Nizi, Emanuela, Andreini, Matteo, Gennari, Nadia, Saccoccia, Fulvio, Harper, Steven, Bresciani, Alberto, Ruberti, Giovina
Published in PLoS neglected tropical diseases (06.10.2017)
Published in PLoS neglected tropical diseases (06.10.2017)
Get full text
Journal Article
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme
Turcano, Lorenzo, Battista, Theo, De Haro, Esther Torrente, Missineo, Antonino, Alli, Cristina, Paonessa, Gicomo, Colotti, Gianni, Harper, Steven, Fiorillo, Annarita, Ilari, Andrea, Bresciani, Alberto
Published in PLoS neglected tropical diseases (21.05.2020)
Published in PLoS neglected tropical diseases (21.05.2020)
Get full text
Journal Article
Proteolytic Activation Cascade of the Netherton Syndrome–Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis
Fortugno, Paola, Bresciani, Alberto, Paolini, Chantal, Pazzagli, Chiara, El Hachem, May, D'Alessio, Marina, Zambruno, Giovanna
Published in Journal of investigative dermatology (01.11.2011)
Published in Journal of investigative dermatology (01.11.2011)
Get full text
Journal Article
Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production
Guidi, Alessandra, Saccoccia, Fulvio, Gennari, Nadia, Gimmelli, Roberto, Nizi, Emanuela, Lalli, Cristiana, Paonessa, Giacomo, Papoff, Giuliana, Bresciani, Alberto, Ruberti, Giovina
Published in Parasites & vectors (27.12.2018)
Published in Parasites & vectors (27.12.2018)
Get full text
Journal Article
Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems
Guidi, Alessandra, Lalli, Cristiana, Perlas, Emerald, Bolasco, Giulia, Nibbio, Martina, Monteagudo, Edith, Bresciani, Alberto, Ruberti, Giovina
Published in PLoS neglected tropical diseases (12.08.2016)
Published in PLoS neglected tropical diseases (12.08.2016)
Get full text
Journal Article
Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro
Ferrigno, Federica, Biancofiore, Ilaria, Malancona, Savina, Ponzi, Simona, Paonessa, Giacomo, Graziani, Rita, Bresciani, Alberto, Gennari, Nadia, Di Marco, Annalise, Kaiser, Marcel, Summa, Vincenzo, Harper, Steven, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Get full text
Journal Article
Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Daldin, Manuel, Fodale, Valentina, Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Spiezia, Maria Carolina, Deguire, Sean M., Cherubini, Marta, Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto, Vonsattel, Jean-Paul Gerard, Petricca, Lara, Marsh, J. Lawrence, Gines, Silvia, Santimone, Iolanda, Marano, Massimo, Lashuel, Hilal A., Squitieri, Ferdinando, Caricasole, Andrea
Published in Scientific reports (11.07.2017)
Published in Scientific reports (11.07.2017)
Get full text
Journal Article
Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy
Guidi, Alessandra, Petrella, Greta, Fustaino, Valentina, Saccoccia, Fulvio, Lentini, Sara, Gimmelli, Roberto, Di Pietro, Giulia, Bresciani, Alberto, Cicero, Daniel Oscar, Ruberti, Giovina
Published in PLoS neglected tropical diseases (01.10.2020)
Published in PLoS neglected tropical diseases (01.10.2020)
Get full text
Journal Article
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes
Paonessa, Giacomo, Siciliano, Giulia, Graziani, Rita, Lalli, Cristiana, Cecchetti, Ottavia, Alli, Cristina, La Valle, Roberto, Petrocchi, Alessia, Sferrazza, Alessio, Bisbocci, Monica, Falchi, Mario, Toniatti, Carlo, Bresciani, Alberto, Alano, Pietro
Published in Communications biology (06.06.2022)
Published in Communications biology (06.06.2022)
Get full text
Journal Article
Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
Pesce, Elisa, Miluzio, Annarita, Turcano, Lorenzo, Minici, Claudia, Cirino, Delia, Calamita, Piera, Manfrini, Nicola, Oliveto, Stefania, Ricciardi, Sara, Grifantini, Renata, Degano, Massimo, Bresciani, Alberto, Biffo, Stefano
Published in Cells (Basel, Switzerland) (10.01.2020)
Published in Cells (Basel, Switzerland) (10.01.2020)
Get full text
Journal Article
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis
Reggio, Alessio, Rosina, Marco, Palma, Alessandro, Cerquone Perpetuini, Andrea, Petrilli, Lucia Lisa, Gargioli, Cesare, Fuoco, Claudia, Micarelli, Elisa, Giuliani, Giulio, Cerretani, Mauro, Bresciani, Alberto, Sacco, Francesca, Castagnoli, Luisa, Cesareni, Gianni
Published in Cell death and differentiation (01.10.2020)
Published in Cell death and differentiation (01.10.2020)
Get full text
Journal Article