NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model
Moretti, Daniele, Tambone, Sara, Cerretani, Mauro, Fezzardi, Paola, Missineo, Antonino, Sherman, Leticia-Toledo, Munoz-Sajuan, Ignacio, Harper, Steven, Dominquez, Celia, Pacifici, Robert, Tomei, Licia, Park, Larry, Bresciani, Alberto
Published in Free radical biology & medicine (01.01.2021)
Published in Free radical biology & medicine (01.01.2021)
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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1)
Bresciani, Alberto, Missineo, Antonino, Gallo, Mariana, Cerretani, Mauro, Fezzardi, Paola, Tomei, Licia, Cicero, Daniel Oscar, Altamura, Sergio, Santoprete, Alessia, Ingenito, Raffaele, Bianchi, Elisabetta, Pacifici, Robert, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Harper, Steven, Toledo-Sherman, Leticia, Park, Larry C.
Published in Archives of biochemistry and biophysics (01.10.2017)
Published in Archives of biochemistry and biophysics (01.10.2017)
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Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases
Chierichetti, Marta, Cerretani, Mauro, Ciammaichella, Alina, Crippa, Valeria, Rusmini, Paola, Ferrari, Veronica, Tedesco, Barbara, Casarotto, Elena, Cozzi, Marta, Mina, Francesco, Pramaggiore, Paola, Galbiati, Mariarita, Piccolella, Margherita, Bresciani, Alberto, Cristofani, Riccardo, Poletti, Angelo
Published in Life sciences (1973) (01.06.2023)
Published in Life sciences (1973) (01.06.2023)
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AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington’s disease mouse model
Thomson, Sarah B, Stam, Anouk, Brouwers, Cynthia, Fodale, Valentina, Bresciani, Alberto, Vermeulen, Michael, Mostafavi, Sara, Petkau, Terri L, Hill, Austin, Yung, Andrew, Russell-Schulz, Bretta, Kozlowski, Piotr, MacKay, Alex, Ma, Da, Beg, Mirza Faisal, Evers, Melvin M, Vallès, Astrid, Leavitt, Blair R
Published in Brain (London, England : 1878) (01.06.2023)
Published in Brain (London, England : 1878) (01.06.2023)
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Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy
Vallès, Astrid, Evers, Melvin M, Stam, Anouk, Sogorb-Gonzalez, Marina, Brouwers, Cynthia, Vendrell-Tornero, Carlos, Acar-Broekmans, Seyda, Paerels, Lieke, Klima, Jiri, Bohuslavova, Bozena, Pintauro, Roberta, Fodale, Valentina, Bresciani, Alberto, Liscak, Roman, Urgosik, Dusan, Starek, Zdenek, Crha, Michal, Blits, Bas, Petry, Harald, Ellederova, Zdenka, Motlik, Jan, van Deventer, Sander, Konstantinova, Pavlina
Published in Science translational medicine (07.04.2021)
Published in Science translational medicine (07.04.2021)
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A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation
Acchioni, Chiara, Acchioni, Marta, Mancini, Flavia, Amendola, Antonello, Marsili, Giulia, Tirelli, Valentina, Gwee, Chin Piaw, Chan, Kitti Wing-Ki, Sandini, Silvia, Bisbocci, Monica, Mysara, Mohamed, ElHefnawi, Mahmoud, Sanchez, Massimo, Venturi, Giulietta, Barreca, Maria Letizia, Manfroni, Giuseppe, Bresciani, Alberto, Vasudevan, Subhash G., Sgarbanti, Marco
Published in Virology (New York, N.Y.) (01.06.2023)
Published in Virology (New York, N.Y.) (01.06.2023)
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Aspergillus olivimuriae sp. nov., a halotolerant species isolated from olive brine
Crognale, Silvia, Pesciaroli, Lorena, Felli, Martina, Petruccioli, Maurizio, D'Annibale, Alessandro, Bresciani, Alberto, Peterson, Stephen W
Published in International journal of systematic and evolutionary microbiology (01.09.2019)
Published in International journal of systematic and evolutionary microbiology (01.09.2019)
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Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Andreini, Matteo, Cerretani, Mauro, Missineo, Antonino, Moretti, Daniele, Tambone, Sara, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Munoz-Sanjuan, Ignacio, Park, Larry, Summa, Vincenzo, Tomei, Licia, Bresciani, Alberto, Dominguez, Celia, Toledo-Sherman, Leticia, Bianchi, Elisabetta
Published in Bioorganic & medicinal chemistry (01.11.2020)
Published in Bioorganic & medicinal chemistry (01.11.2020)
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SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Colarusso, Stefania, Ferrigno, Federica, Ponzi, Simona, Pavone, Francesca, Conte, Immacolata, Abate, Luigi, Beghetto, Elisa, Missineo, Antonino, Amaudrut, Jerome, Bresciani, Alberto, Paonessa, Giacomo, Tomei, Licia, Montalbetti, Christian, Bianchi, Elisabetta, Toniatti, Carlo, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry (01.03.2022)
Published in Bioorganic & medicinal chemistry (01.03.2022)
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Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents
Randazzo, Pietro, Sinisi, Roberta, Gornati, Davide, Bertuolo, Stefania, Bencheva, Leda, De Matteo, Marilenia, Nibbio, Martina, Monteagudo, Edith, Turcano, Lorenzo, Bianconi, Valeria, Peruzzi, Giovanna, Summa, Vincenzo, Bresciani, Alberto, Mozzetta, Chiara, Di Fabio, Romano
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
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Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin‑2 for Cardiovascular Diseases
Mallart, Sergio, Ingenito, Raffaele, Bianchi, Elisabetta, Bresciani, Alberto, Esposito, Simone, Gallo, Mariana, Magotti, Paola, Monteagudo, Edith, Orsatti, Laura, Roversi, Daniela, Santoprete, Alessia, Tucci, Federica, Veneziano, Maria, Bartsch, Régine, Boehm, Claudius, Brasseur, Denis, Bruneau, Patricia, Corbier, Alain, Froissant, Jacques, Gauzy-Lazo, Laurence, Gervat, Vincent, Marguet, Frank, Menguy, Isabelle, Minoletti, Claire, Nicolas, Marie-Françoise, Pasquier, Olivier, Poirier, Bruno, Raux, Alexandre, Riva, Laurence, Janiak, Philip, Strobel, Hartmut, Duclos, Olivier, Illiano, Stephane
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors
Ponzi, Simona, Bresciani, Alberto, Kaiser, Marcel, Nardi, Valentina, Nizi, Emanuela, Ontoria, Jesus M., Pace, Paola, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
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Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay
Fodale, Valentina, Pintauro, Roberta, Daldin, Manuel, Spiezia, Maria Carolina, Macdonald, Douglas, Bresciani, Alberto
Published in Journal of Huntington's disease (01.01.2022)
Published in Journal of Huntington's disease (01.01.2022)
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Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters
Breveglieri, Giulia, Salvatori, Francesca, Finotti, Alessia, Cosenza, Lucia Carmela, Zuccato, Cristina, Bianchi, Nicoletta, Breda, Laura, Rivella, Stefano, Bresciani, Alberto, Bisbocci, Monica, Borgatti, Monica, Gambari, Roberto
Published in Analytical and bioanalytical chemistry (01.11.2019)
Published in Analytical and bioanalytical chemistry (01.11.2019)
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Fish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens
Buonocore, Francesco, Picchietti, Simona, Porcelli, Fernando, Della Pelle, Giulia, Olivieri, Cristina, Poerio, Elia, Bugli, Francesca, Menchinelli, Giulia, Sanguinetti, Maurizio, Bresciani, Alberto, Gennari, Nadia, Taddei, Anna Rita, Fausto, Anna Maria, Scapigliati, Giuseppe
Published in Developmental and comparative immunology (01.07.2019)
Published in Developmental and comparative immunology (01.07.2019)
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Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors
Cerquone Perpetuini, Andrea, Giuliani, Giulio, Reggio, Alessio, Cerretani, Mauro, Santoriello, Marisabella, Stefanelli, Roberta, Palma, Alessandro, Vumbaca, Simone, Harper, Steven, Castagnoli, Luisa, Bresciani, Alberto, Cesareni, Gianni
Published in Scientific reports (24.03.2020)
Published in Scientific reports (24.03.2020)
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Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
Nizi, Emanuela, Sferrazza, Alessio, Fabbrini, Danilo, Nardi, Valentina, Andreini, Matteo, Graziani, Rita, Gennari, Nadia, Bresciani, Alberto, Paonessa, Giacomo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by .sup.1H-NMR spectroscopy
Gimmelli, Roberto, Ruberti, Giovina, Di Pietro, Giulia, Bresciani, Alberto, Cicero, Daniel Oscar, Lentini, Sara, Guidi, Alessandra, Saccoccia, Fulvio, Fustaino, Valentina, Petrella, Greta
Published in PLoS neglected tropical diseases (12.10.2020)
Published in PLoS neglected tropical diseases (12.10.2020)
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