Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.
Published in Cancer cell (01.02.2005)
Published in Cancer cell (01.02.2005)
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Journal Article
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Journal Article
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities
Mancuso, Riccardo V., Schneider, Gisbert, Hürzeler, Marianne, Gut, Martin, Zurflüh, Jonas, Breitenstein, Werner, Bouitbir, Jamal, Reisen, Felix, Atz, Kenneth, Ehrhardt, Claus, Duthaler, Urs, Gygax, Daniel, Schmidt, Albrecht G., Krähenbühl, Stephan, Weitz-Schmidt, Gabriele
Published in Biochemical pharmacology (01.05.2023)
Published in Biochemical pharmacology (01.05.2023)
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Journal Article
Recent trends and observations in the design of high-quality screening collections
Renner, Steffen, Popov, Maxim, Schuffenhauer, Ansgar, Roth, Hans-Joerg, Breitenstein, Werner, Marzinzik, Andreas, Lewis, Ian, Krastel, Philipp, Nigsch, Florian, Jenkins, Jeremy, Jacoby, Edgar
Published in Future medicinal chemistry (01.04.2011)
Published in Future medicinal chemistry (01.04.2011)
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Journal Article
ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans
John, Markus R, Widler, Leo, Gamse, Rainer, Buhl, Thomas, Seuwen, Klaus, Breitenstein, Werner, Bruin, Gerard J.M, Belleli, Rossella, Klickstein, Lloyd B, Kneissel, Michaela
Published in Bone (New York, N.Y.) (01.08.2011)
Published in Bone (New York, N.Y.) (01.08.2011)
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Journal Article
The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches
Lorthiois, Edwige, Breitenstein, Werner, Cumin, Frederic, Ehrhardt, Claus, Francotte, Eric, Jacoby, Edgar, Ostermann, Nils, Sellner, Holger, Kosaka, Takatoshi, Webb, Randy L, Rigel, Dean F, Hassiepen, Ulrich, Richert, Paul, Wagner, Trixie, Maibaum, Jürgen
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Journal Article
A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P-3-P-1 Pharmacophore
Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D., Cumin, Frederic, Hassiepen, Ulrich, Trappe, Joerg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Kroemer, Markus, Kosaka, Takatoshi, Webb, Randy L., Rigel, Dean F., Maibaum, Juergen, Baeschlin, Daniel K.
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Journal Article
A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore
Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D, Cumin, Frederic, Hassiepen, Ulrich, Trappe, Jörg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Krömer, Markus, Kosaka, Takatoshi, Webb, Randy L, Rigel, Dean F, Maibaum, Jürgen, Baeschlin, Daniel K
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Journal Article
New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck
Gommermann, Nina, Buehlmayer, Peter, von Matt, Anette, Breitenstein, Werner, Masuya, Keiichi, Pirard, Bernard, Furet, Pascal, Cowan-Jacob, Sandra W., Weckbecker, Gisbert
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists
Widler, Leo, Altmann, Eva, Beerli, René, Breitenstein, Werner, Bouhelal, Rochdi, Buhl, Thomas, Gamse, Rainer, Gerspacher, Marc, Halleux, Christine, John, Markus R, Lehmann, Hansjoerg, Kalb, Oskar, Kneissel, Michaela, Missbach, Martin, Müller, Irene R, Reidemeister, Sibylle, Renaud, Johanne, Taillardat, Agnes, Tommasi, Ruben, Weiler, Sven, Wolf, Romain M, Seuwen, Klaus
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
LFA-1 SMALL MOLECULE LFA-1 INHIBITORS
SCHNEIDER GISBERT, WEITZ SCHMIDT GABRIELE, KELLY TERENCE, BREITENSTEIN WERNER, HUERZELER MARIANNE, MANCUSO RICCARDO
Year of Publication 02.02.2017
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Year of Publication 02.02.2017
Patent
Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors
Ehara, Takeru, Irie, Osamu, Kosaka, Takatoshi, Kanazawa, Takanori, Breitenstein, Werner, Grosche, Philipp, Ostermann, Nils, Suzuki, Masaki, Kawakami, Shimpei, Konishi, Kazuhide, Hitomi, Yuko, Toyao, Atsushi, Gunji, Hiroki, Cumin, Frederic, Schiering, Nikolaus, Wagner, Trixie, Rigel, Dean F, Webb, Randy L, Maibaum, Jürgen, Yokokawa, Fumiaki
Published in ACS medicinal chemistry letters (10.07.2014)
Published in ACS medicinal chemistry letters (10.07.2014)
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Journal Article
The use of MPA amide for the assignment of absolute configuration of a sterically hindered cyclic secondary amine by 'mix and shake' NMR method
Gao, Jinhai, Haas, Hansjoerg, Wang, Kate Yaping, Chen, Zhuoliang, Breitenstein, Werner, Rajan, Srinivasan
Published in Magnetic resonance in chemistry (01.01.2008)
Published in Magnetic resonance in chemistry (01.01.2008)
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Journal Article
1-Alkyl-4-phenyl-6-alkoxy-1 H -quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists
Widler, Leo, Altmann, Eva, Beerli, René, Breitenstein, Werner, Bouhelal, Rochdi, Buhl, Thomas, Gamse, Rainer, Gerspacher, Marc, Halleux, Christine, John, Markus R., Lehmann, Hansjoerg, Kalb, Oskar, Kneissel, Michaela, Missbach, Martin, Müller, Irene R., Reidemeister, Sibylle, Renaud, Johanne, Taillardat, Agnes, Tommasi, Ruben, Weiler, Sven, Wolf, Romain M., Seuwen, Klaus
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
BROOKS CLINTON, LOREN JON, LIU XIAODONG, WRONA WOJCIECH, REVESZ LASZLO, PEREZ LAWRENCE B, CHIANELLI DONATELLA, NABAKKA JULIET, MANLEY PAUL W, LI XIAOLIN, MOLTENI VALENTINA, BREITENSTEIN WERNER
Year of Publication 16.05.2012
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Year of Publication 16.05.2012
Patent
Inhibitors of tyrosine kinases
Manley, Paul William, Breitenstein, Werner, Furet, Pascal, Jacob, Sandra
Year of Publication 30.06.2022
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Year of Publication 30.06.2022
Patent
Inhibitors of tyrosine kinases
Manley, Paul William, Breitenstein, Werner, Furet, Pascal, Jacob, Sandra
Year of Publication 09.06.2022
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Year of Publication 09.06.2022
Patent
PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE
VON MATT ANETTE, PIRARD BERNARD, FURET PASCAL, ZOLLER THOMAS, BUEHLMAYER PETER, BREITENSTEIN WERNER
Year of Publication 02.07.2009
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Year of Publication 02.07.2009
Patent
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
BROOKS CLINTON, LOREN JON, LIU XIAODONG, WRONA WOJCIECH, REVESZ LASZLO, PEREZ LAWRENCE B, CHIANELLI DONATELLA, NABAKKA JULIET, MANLEY PAUL W, LI XIAOLIN, MOLTENI VALENTINA, BREITENSTEIN WERNER
Year of Publication 09.07.2009
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Year of Publication 09.07.2009
Patent