Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction
Barrett, T D, Yan, W, Freedman, J M, Lagaud, G J, Breitenbucher, J G, Shankley, N P
Published in British journal of pharmacology (01.04.2008)
Published in British journal of pharmacology (01.04.2008)
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Journal Article
Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity: Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator
Mackman, Richard L, Katz, Bradley A, Breitenbucher, J. Guy, Hui, Hon C, Verner, Erik, Luong, Christine, Liu, Liang, Sprengeler, Paul A
Published in Journal of medicinal chemistry (08.11.2001)
Published in Journal of medicinal chemistry (08.11.2001)
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Journal Article
Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist
Swanson, Devin M, Dubin, Adrienne E, Shah, Chandra, Nasser, Nadia, Chang, Leon, Dax, Scott L, Jetter, Michele, Breitenbucher, J. Guy, Liu, Changlu, Mazur, Curt, Lord, Brian, Gonzales, Lisa, Hoey, Kenway, Rizzolio, Michele, Bogenstaetter, Michael, Codd, Ellen E, Lee, Doo H, Zhang, Sui-Po, Chaplan, Sandra R, Carruthers, Nicholas I
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles
Arienti, Kristen L, Brunmark, Anders, Axe, Frank U, McClure, Kelly, Lee, Alice, Blevitt, Jon, Neff, Danielle K, Huang, Liming, Crawford, Shelby, Pandit, Chennagiri R, Karlsson, Lars, Breitenbucher, J. Guy
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets
Katz, Bradley A, Sprengeler, Paul A, Luong, Christine, Verner, Erik, Elrod, Kyle, Kirtley, Matt, Janc, James, Spencer, Jeffrey R, Breitenbucher, J.Guy, Hui, Hon, McGee, Danny, Allen, Darin, Martelli, Arnold, Mackman, Richard L
Published in Chemistry & biology (01.11.2001)
Published in Chemistry & biology (01.11.2001)
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Journal Article
Non-imidazole heterocyclic histamine H 3 receptor antagonists
Chai, Wenying, Breitenbucher, J.Guy, Kwok, Annette, Li, Xiaobing, Wong, Victoria, Carruthers, Nicholas I., Lovenberg, Timothy W., Mazur, Curt, Wilson, Sandy J., Axe, Frank U., Jones, Todd K.
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Journal Article
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.
Published in European journal of pharmacology (01.08.2011)
Published in European journal of pharmacology (01.08.2011)
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Journal Article
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
Novel non-benzimidazole chk2 kinase inhibitors
McClure, Kelly J., Huang, Liming, Arienti, Kristen L., Axe, Frank U., Brunmark, Anders, Blevitt, Jon, Guy Breitenbucher, J.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity
SEHON, Clark, MCCLURE, Kelly, HACK, Michael, MORTON, Magda, GOMEZ, Laurent, LI, Lina, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Journal Article
Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity
MCCLURE, Kelly, HACK, Michael, LIMING HUANG, SEHON, Clark, MORTON, Magda, LINA LI, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Journal Article
Novel human histamine H 3 receptor antagonists
Shah, Chandra, McAtee, Laura, Breitenbucher, J.Guy, Rudolph, Dale, Li, Xiaobing, Lovenberg, Timothy W, Mazur, Curt, Wilson, Sandy J, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Journal Article
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms
Chang, Leon, Luo, Lin, Palmer, James A, Sutton, Steven, Wilson, Sandy J, Barbier, Ann J, Breitenbucher, James Guy, Chaplan, Sandra R, Webb, Michael
Published in British journal of pharmacology (01.05.2006)
Published in British journal of pharmacology (01.05.2006)
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Journal Article
2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
MACKMAN, Richard L, HUI, Hon C, SPRENGELER, Paul A, TARIO, James, VERNER, Erik, JING WANG, BREITENBUCHER, J. Guy, KATZ, Bradley A, LUONG, Christine, MARTELLI, Arnold, MCGEE, Danny, RADIKA, Kesavan, SENDZIK, Martin, SPENCER, Jeffrey R
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
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