Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2-, alpha 6 beta 2-, alpha 3 beta 4- and alpha 7-nicotine acetylcholine receptors
Grady, Sharon R, Drenan, Ryan M, Breining, Scott R, Yohannes, Daniel, Wageman, Charles R, Fedorov, Nikolai B, McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A, Marks, Michael J
Published in Neuropharmacology (01.06.2010)
Published in Neuropharmacology (01.06.2010)
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Journal Article
Structure–Activity Studies of 7‑Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands
Breining, Scott R, Melvin, Matt, Bhatti, Balwinder S, Byrd, Gary D, Kiser, Melanie N, Hepler, Christopher D, Hooker, Dawn N, Zhang, Jenny, Reynolds, Leslie A, Benson, Lisa R, Fedorov, Nikolai B, Sidach, Serguei S, Mitchener, J. Pike, Lucero, Linda M, Lukas, Ronald J, Whiteaker, Paul, Yohannes, Daniel
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Journal Article
Structural differences determine the relative selectivity of nicotinic compounds for native α4β2-, α6β2-, α3β4- and α7-nicotine acetylcholine receptors
Grady, Sharon R., Drenan, Ryan M., Breining, Scott R., Yohannes, Daniel, Wageman, Charles R., Fedorov, Nikolai B., McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A., Marks, Michael J.
Published in Neuropharmacology (01.06.2010)
Published in Neuropharmacology (01.06.2010)
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Journal Article
Development of a Scalable Synthesis of a Pyridinyl-3-azabicyclononene, a Novel Nicotinic Partial Agonist
Breining, Scott R, Genus, John F, Mitchener, J. Pike, Cuthbertson, Timothy J, Heemstra, Ronald, Melvin, Matt S, Dull, Gary M, Yohannes, Daniel
Published in Organic process research & development (15.03.2013)
Published in Organic process research & development (15.03.2013)
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Journal Article
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR)
Kombo, David C., Hauser, Terry A., Grinevich, Vladimir P., Melvin, Matthew S., Strachan, Jon-Paul, Sidach, Serguei S., Chewning, Joseph, Fedorov, Nikolai, Tallapragada, Kartik, Breining, Scott R., Miller, Craig H.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6∗ subtype
Breining, Scott R., Bencherif, Merouane, Grady, Sharon R., Whiteaker, Paul, Marks, Michael J., Wageman, Charles R., Lester, Henry A., Yohannes, Daniel
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands
Bhatti, Balwinder S, Strachan, Jon-Paul, Breining, Scott R, Miller, Craig H, Tahiri, Persida, Crooks, Peter A, Deo, Niranjan, Day, Cynthia S, Caldwell, William S
Published in Journal of organic chemistry (02.05.2008)
Published in Journal of organic chemistry (02.05.2008)
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Journal Article
Comparison of binding and functional activity profiles for a set of nicotinic acetylcholine receptor ligands across multiple α6 expression systems
Breining, Scott R., Hepler, Christopher, Whiteaker, Paul, Quik, Maryka, Grady, Sharon R., Yohannes, Daniel
Published in Biochemical pharmacology (01.10.2011)
Published in Biochemical pharmacology (01.10.2011)
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Journal Article
Structural differences determine the relative selectivity of nicotinic compounds for native a4b2-, a6b2-, a3b4- and a7-nicotine acetylcholine receptors
Grady, Sharon R, Drenan, Ryan M, Breining, Scott R, Yohannes, Daniel, Wageman, Charles R, Fedorov, Nikolai B, McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A, Marks, Michael J
Published in Neuropharmacology (01.06.2010)
Published in Neuropharmacology (01.06.2010)
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Journal Article
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha 6 super() subtype
Breining, Scott R, Bencherif, Merouane, Grady, Sharon R, Whiteaker, Paul, Marks, Michael J, Wageman, Charles R, Lester, Henry A, Yohannes, Daniel
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS
HEEMSTRA RONALD JOSEPH, MURTHY SRINIVASA V, MELVIN MATT S, XIAO YUNDE, HAMMOND PHILIP S, BHATTI BALWINDER SINGH, SHOWALTER TODD, YOHANNES DANIEL, AKIREDDY SRINIVASA RAO, MIAO LAN, STRACHAN JON PAUL, BREINING SCOTT R, SPEAKE JASON, MAZUROV ANATOLY A, KOMBO DAVID
Year of Publication 28.03.2014
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Year of Publication 28.03.2014
Patent
PREPARATION AND ENANTIOMERIC SEPARATION OF 7-(3-PYRIDINYL)-1,7-DIAZASPIRO[4.4]NONANE AND NOVEL SALT FORMS OF THE RACEMATE AND ENANTIOMERS
BREINING SCOTT, XIE JIANXUN, BEAVER JESSICA, TOLER STEVE M, WAMSLEY JAMES, MATHEW JACOB, GENUS JOHN, GATTO GERGORY J, MUNOZ JULIO A, DULL GARY MAURICE, PFEIFFER INIGO
Year of Publication 04.11.2010
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Year of Publication 04.11.2010
Patent
(R)-3-(E)-2-(PYRROLIDIN-3-YL)VINYL)-5-(TETRAHYDROPYRAN-4-YLOXY)PYRIDINE, ITS SALTS, ITS SYNTHESIS AND ITS USE AS LIGAND FOR NICOTINIC ACETYLCHOLINERGIC RECEPTORS
GATTO GREGORY J, YOHANNES DANIEL, CUTHBERTSON TIMOTHY J, MITCHENER JOSEPH PIKE JR, OTTEN PIETER ALBERT, GENUS JOHN, MUNOZ JULIO A, FEDOROV NIKOLAI, AKIREDDY SRINIVISA RAO, BREINING SCOTT R, DULL GARY MAURICE, HAMMOND PHILIP S
Year of Publication 23.08.2011
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Year of Publication 23.08.2011
Patent
NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES
MURTHY V. SRINIVASA, MELVIN MATT S, MIAO LAN, MILLER CRAIG H, WHITAKER REGINA C, AKIREDDY SRINIVISA RAO, MAZUROV ANATOLY, HAMMOND PHILIP S, BREINING SCOTT R, XIAO YUN DE
Year of Publication 26.11.2010
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Year of Publication 26.11.2010
Patent
NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES
MURTHY V. SRINIVASA, HEEMSTRA RONALD JOSEPH, MELVIN MATT S, MIAO LAN, AKIREDDY SRINIVISA RAO, STRACHAN JON PAUL, BREINING SCOTT R, HAMMOND PHILIP S, MAZUROV ANATOLY, BHATTI BALWINDER SINGH, XIAO YUN DE
Year of Publication 22.11.2010
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Year of Publication 22.11.2010
Patent
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( ) subtype
Breining, Scott R, Bencherif, Merouane, Grady, Sharon R, Whiteaker, Paul, Marks, Michael J, Wageman, Charles R, Lester, Henry A, Yohannes, Daniel
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES
MURTHY V. SRINIVASA, MELVIN MATT S, MIAO LAN, MILLER CRAIG H, WHITAKER REGINA C, AKIREDDY SRINIVISA RAO, MAZUROV ANATOLY, HAMMOND PHILIP S, BREINING SCOTT R, XIAO YUN DE
Year of Publication 03.07.2009
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Year of Publication 03.07.2009
Patent