Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent
Theoclitou, Maria-Elena, Aquila, Brian, Block, Michael H, Brassil, Patrick J, Castriotta, Lillian, Code, Erin, Collins, Michael P, Davies, Audrey M, Deegan, Tracy, Ezhuthachan, Jayachandran, Filla, Sandra, Freed, Ellen, Hu, Haiqing, Huszar, Dennis, Jayaraman, Muthusamy, Lawson, Deborah, Lewis, Paula M, Nadella, Murali V. P, Oza, Vibha, Padmanilayam, Maniyan, Pontz, Timothy, Ronco, Lucienne, Russell, Daniel, Whitston, David, Zheng, Xiaolan
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Journal Article
Estimation of human drug clearance using multiexponential techniques
Goteti, Kosalaram, Brassil, Patrick J, Good, Steven S, Garner, C Edwin
Published in Journal of clinical pharmacology (01.10.2008)
Published in Journal of clinical pharmacology (01.10.2008)
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Journal Article
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice
Burke, James R., Pattoli, Mark A., Gregor, Kurt R., Brassil, Patrick J., MacMaster, John F., McIntyre, Kim W., Yang, Xiaoxia, Iotzova, Violetta S., Clarke, Wendy, Strnad, Joann, Qiu, Yuping, Zusi, F. Christopher
Published in The Journal of biological chemistry (17.01.2003)
Published in The Journal of biological chemistry (17.01.2003)
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Journal Article
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents
Goteti, Kosalaram, Edwin Garner, C, Utley, Lucas, Dai, Jing, Ashwell, Susan, Moustakas, Demetri T, Gönen, Mithat, Schwartz, Gary K, Kern, Steven E, Zabludoff, Sonya, Brassil, Patrick J
Published in Cancer chemotherapy and pharmacology (01.07.2010)
Published in Cancer chemotherapy and pharmacology (01.07.2010)
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Journal Article
Synthesis and structure–activity relationship of imidazo(1,2- a)thieno(3,2- e)pyrazines as IKK-β inhibitors
Belema, Makonen, Bunker, Amy, Nguyen, Van N., Beaulieu, Francis, Ouellet, Carl, Qiu, Yuping, Zhang, Yunhui, Martel, Alain, Burke, James R., McIntyre, Kim W., Pattoli, Mark A., Daloisio, Connie, Gillooly, Kathleen M., Clarke, Wendy J., Brassil, Patrick J., Zusi, F. Chris, Vyas, Dolatrai M.
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
야누스 키나아제 저해제의 글루쿠로니드 프로드러그
LONG DANIEL D, HUDSON RYAN, BRASSIL PATRICK J, LOO MANDY, WILTON DONNA A.A
Year of Publication 30.01.2020
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Year of Publication 30.01.2020
Patent
Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies
Schulz, Thomas G, Thiel, Renate, Neubert, Diether, Brassil, Patrick J, Schulz-Utermoehl, Timothy, Boobis, Alan R, Edwards, Robert J
Published in Biochimica et biophysica acta (09.03.2001)
Published in Biochimica et biophysica acta (09.03.2001)
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위장관 염증 질환의 치료를 위한 JAK 저해제 화합물의 프로드러그
LONG DANIEL D, HUDSON RYAN, BRASSIL PATRICK J, LOO MANDY, WILTON DONNA A.A
Year of Publication 11.07.2018
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Year of Publication 11.07.2018
Patent
Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130
Taber, Matthew T., Wright, Robert N., Molski, Thaddeus F., Clarke, Wendy J., Brassil, Patrick J., Denhart, Derek J., Mattson, Ronald J., Lodge, Nicholas J.
Published in Pharmacology, biochemistry and behavior (01.03.2005)
Published in Pharmacology, biochemistry and behavior (01.03.2005)
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Journal Article
BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A2 That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models
Burke, J R, Davern, L B, Stanley, P L, Gregor, K R, Banville, J, Remillard, R, Russell, J W, Brassil, P J, Witmer, M R, Johnson, G, Tredup, J A, Tramposch, K M
Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
Journal Article
Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-metlyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-metlylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent
Theoclitou, Maria-Elena, Aquila, Brian, Block, Michael H., Brassil, Patrick J., Castriotta, Lillian, Code, Erin, Collins, Michael P., Davies, Audrey M., Deegan, Tracy, Ezhuthachan, Jayachandran, Filla, Sandra, Freed, Ellen, Hu, Haiqing, Huszar, Dennis, Jayaraman, Muthusamy, Lawson, Deborah, Lewis, Paula M., Nadella, Murali V. P., Oza, Vibha, Padmanilayam, Maniyan, Pontz, Timothy, Ronco, Lucienne, Russell, Daniel, Whitston, David, Zheng, Xiaolan
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Journal Article
Prodrugs of a JAK inhibitor compound for treatment of gastrointestinal inflammatory disease
Hudson, Ryan, Brassil, Patrick J, Loo, Mandy, Wilton, Donna A. A, Long, Daniel D
Year of Publication 21.03.2023
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Year of Publication 21.03.2023
Patent
Glucuronide prodrugs of janus kinase inhibitors
Hudson, Ryan, Brassil, Patrick J, Wilton, Donna A.a, Loo, Mandy, Long, Daniel D
Year of Publication 01.07.2022
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Year of Publication 01.07.2022
Patent
PRODRUGS OF A JAK INHIBITOR COMPOUND FOR TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISEASE
WILTON, Donna A.A, LONG, Daniel D, LOO, Mandy, HUDSON, Ryan, BRASSIL, Patrick J
Year of Publication 22.03.2022
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Year of Publication 22.03.2022
Patent
Glucuronide prodrugs of Janus kinase inhibitors
Hudson, Ryan, Brassil, Patrick J, Wilton, Donna A.A, Loo, Mandy, Long, Daniel D
Year of Publication 30.09.2021
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Year of Publication 30.09.2021
Patent
Prodrugs of a JAK Inhibitor Compound for Treatment of Gastrointestinal Inflammatory Disease
Hudson, Ryan, Brassil, Patrick J, Wilton, Donna A.A, Loo, Mandy, Long, Daniel D
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
Patent