R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Journal Article
JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice
Chang, Betty Y, Zhao, Feifei, He, Xiaodong, Ren, Hong, Braselmann, Sylvia, Taylor, Vanessa, Wicks, Joan, Payan, Donald G, Grossbard, Elliott B, Pine, Polly R, Bullard, Daniel C
Published in The Journal of immunology (1950) (01.08.2009)
Published in The Journal of immunology (1950) (01.08.2009)
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Tuning the Reactivity of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy
Markovtsov, Vadim, Duncton, Matthew A. J., Bagos, Art, Yi, Sothy, Braselmann, Sylvia, Bhamidipati, Somasekhar, Darwish, Ihab S., Yu, Jiaxin, Owyang, Alexander M., Fernandez, Beth, Samant, Bhushan, Park, Gary, Masuda, Esteban S., Shaw, Simon J.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Abstract 346: Potential role for R191, potent and selective IRAK4 kinase inhibitor, in treatment of hematologic malignancies
Markovtsov, Vadim V., Lamagna, Chrystelle, Chan, Meagan, Yi, Sothy, Young, Chi, Frances, Roy, Siu, Stacey, Braselmann, Sylvia, Li, Hui, Singh, Rajinder, Park, Gary, Masuda, Esteban, Taylor, Vanessa, Payan, Donald G.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 4869: Small molecule inhibitors of the anti-inflammatory TAM receptor MerTK
Holland, Sacha J., Owyang, Alex M., Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Arthur, Tai, Ernest, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Duncton, Matthew, Singh, Rajinder, Masuda, Esteban, Payan, Donald G.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases
Lamagna, Chrystelle, Chan, Meagan, Yi, Sothy, Young, Chi, Frances, Roy, Siu, Stacey, Braselmann, Sylvia, Payan, Donald G, McMurtrie, Darren, Kelley, Ryan, Heckrodt, Thilo, Yen, Rose, Chen, Yan, Li, Hui, Singh, Rajinder, Park, Gary, Masuda, Esteban, Taylor, Vanessa
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling
Argade, Ankush, Bhamidipati, Somasekhar, Li, Hui, Sylvain, Catherine, Clough, Jeffrey, Carroll, David, Keim, Holger, Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Herlaar, Ellen, Issakani, Sarkiz D., Wong, Brian R., Masuda, Esteban S., Payan, Donald G., Singh, Rajinder
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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In vitro and in vivo characterization of small molecule inhibitors of the anti-inflammatory TAM receptor MerTK
Owyang, Alexander, Holland, Sacha, Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Art, Tai, Ernie, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Yu, Jiaxin, Ding, Pingyu, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Singh, Raj, Payan, Donald G, Masuda, Esteban S
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Identification of the Syk kinase inhibitor R112 by a human mast cell screen
Rossi, Alexander B., Herlaar, Ellen, Braselmann, Sylvia, Huynh, Stacey, Taylor, Vanessa, Frances, Roy, Issakani, Sarkiz D., Argade, Ankush, Singh, Rajinder, Payan, Donald G., Masuda, Esteban S.
Published in Journal of Allergy and Clinical Immunology (01.09.2006)
Published in Journal of Allergy and Clinical Immunology (01.09.2006)
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Identification of the SyR kinase inhibitor R112 by a human mast cell screen
ROSSI, Alexander B, HERLAAR, Ellen, MASUDA, Esteban S, BRASELMANN, Sylvia, HUYNH, Stacey, TAYLOR, Vanessa, FRANCES, Roy, ISSAKANI, Sarkiz D, ARGADE, Ankush, SINGH, Rajinder, PAYAN, Donald G
Published in Journal of allergy and clinical immunology (2006)
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Published in Journal of allergy and clinical immunology (2006)
Journal Article
Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor
BERGERS, G, REIKERSTORFER, A, BRASELMANN, S, GRANINGER, P, BUSSLINGER, M
Published in The EMBO journal (01.03.1994)
Published in The EMBO journal (01.03.1994)
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Characterizing the Interactions between the Two Subunits of the p101/p110γ Phosphoinositide 3-Kinase and Their Role in the Activation of This Enzyme by Gβγ Subunits
Sonja Krugmann, Phillip T. Hawkins, Nancy Pryer, Sylvia Braselmann
Published in The Journal of biological chemistry (11.06.1999)
Published in The Journal of biological chemistry (11.06.1999)
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