Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)
Strotman, Neil A, Baxter, Carl A, Brands, Karel M. J, Cleator, Ed, Krska, Shane W, Reamer, Robert A, Wallace, Debra J, Wright, Timothy J
Published in Journal of the American Chemical Society (01.06.2011)
Published in Journal of the American Chemical Society (01.06.2011)
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Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction
Zhao, Matthew M, McNamara, James M, Ho, Guo-Jie, Emerson, Khateeta M, Song, Zhiguo J, Tschaen, David M, Brands, Karel M. J, Dolling, Ulf-H, Grabowski, Edward J. J, Reider, Paul J, Cottrell, Ian F, Ashwood, Michael S, Bishop, Brian C
Published in Journal of organic chemistry (20.09.2002)
Published in Journal of organic chemistry (20.09.2002)
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Journal Article
Practical Synthesis of the New Carbapenem Antibiotic Ertapenem Sodium
Williams, J. Michael, Brands, Karel M. J, Skerlj, Renato T, Jobson, Ronald B, Marchesini, George, Conrad, Karen M, Pipik, Brenda, Savary, Kimberly A, Tsay, Fuh-Rong, Houghton, Peter G, Sidler, D. Richard, Dolling, Ulf-H, DiMichele, Lisa M, Novak, Thomas J
Published in Journal of organic chemistry (16.09.2005)
Published in Journal of organic chemistry (16.09.2005)
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Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation
Brands, Karel M. J, Payack, Joseph F, Rosen, Jonathan D, Nelson, Todd D, Candelario, Alexander, Huffman, Mark A, Zhao, Matthew M, Li, Jing, Craig, Bridgette, Song, Zhiguo J, Tschaen, David M, Hansen, Karl, Devine, Paul N, Pye, Philip J, Rossen, Kai, Dormer, Peter G, Reamer, Robert A, Welch, Christopher J, Mathre, David J, Tsou, Nancy N, McNamara, James M, Reider, Paul J
Published in Journal of the American Chemical Society (26.02.2003)
Published in Journal of the American Chemical Society (26.02.2003)
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Journal Article
Efficient One-Pot Synthesis of the 2-Aminocarbonylpyrrolidin-4-ylthio-Containing Side Chain of the New Broad-Spectrum Carbapenem Antibiotic Ertapenem
Brands, Karel M. J, Jobson, Ronald B, Conrad, Karen M, Williams, J. Michael, Pipik, Brenda, Cameron, Mark, Davies, Antony J, Houghton, Peter G, Ashwood, Michael S, Cottrell, Ian F, Reamer, Robert A, Kennedy, Derek J, Dolling, Ulf-H, Reider, Paul J
Published in Journal of organic chemistry (12.07.2002)
Published in Journal of organic chemistry (12.07.2002)
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Journal Article
A Practical Synthesis of a γ-Secretase Inhibitor
Scott, Jeremy P, Lieberman, David R, Beureux, Olivier M, Brands, Karel M. J, Davies, Antony J, Gibson, Andrew W, Hammond, Deborah C, McWilliams, Chris J, Stewart, Gavin W, Wilson, Robert D, Dolling, Ulf-H
Published in Journal of organic chemistry (25.05.2007)
Published in Journal of organic chemistry (25.05.2007)
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Journal Article
Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition
Scott, Jeremy P, Oliver, Steven F, Brands, Karel M. J, Brewer, Sarah E, Davies, Antony J, Gibb, Andrew D, Hands, David, Keen, Stephen P, Sheen, Faye J, Reamer, Robert A, Wilson, Robert D, Dolling, Ulf-H
Published in Journal of organic chemistry (14.04.2006)
Published in Journal of organic chemistry (14.04.2006)
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Journal Article
Development of a Phase Transfer Catalyzed Asymmetric Synthesis for an Estrogen Receptor Beta Selective Agonist
Scott, Jeremy P, Ashwood, Michael S, Brands, Karel M. J, Brewer, Sarah E, Cowden, Cameron J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Goodyear, Adrian, Oliver, Steven F, Stewart, Gavin W, Wallace, Debra J
Published in Organic process research & development (01.07.2008)
Published in Organic process research & development (01.07.2008)
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Journal Article
A Novel Crystallization-Induced Diastereomeric Transformation Based on a Reversible Carbon−Sulfur Bond Formation. Application to the Synthesis of a γ-Secretase Inhibitor
Davies, Antony J, Scott, Jeremy P, Bishop, Brian C, Brands, Karel M. J, Brewer, Sarah E, DaSilva, Jimmy O, Dormer, Peter G, Dolling, Ulf-H, Gibb, Andrew D, Hammond, Deborah C, Lieberman, David R, Palucki, Michael, Payack, Joseph F
Published in Journal of organic chemistry (22.06.2007)
Published in Journal of organic chemistry (22.06.2007)
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Journal Article
The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder
Baxter, Carl A, Cleator, Ed, Brands, Karel M. J, Edwards, John S, Reamer, Robert A, Sheen, Faye J, Stewart, Gavin W, Strotman, Neil A, Wallace, Debra J
Published in Organic process research & development (18.03.2011)
Published in Organic process research & development (18.03.2011)
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Journal Article
Development of a General Protocol To Prepare 2H‑1,3-Benzoxazine Derivatives
Qi, Ji, Oliver, Steven F, Xiao, Wensong, Song, Licheng, Brands, Karel M. J
Published in Organic process research & development (20.10.2017)
Published in Organic process research & development (20.10.2017)
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Journal Article
Thermal Hazard Evaluation of 4-Methoxybenzyl Chloride (PMB-Cl)
Brewer, Sarah E, Vickery, Thomas P, Bachert, Donald C, Brands, Karel M. J, Emerson, Khateeta M, Goodyear, Adrian, Kumke, Kathleen J, Lam, Thientu, Scott, Jeremy P
Published in Organic process research & development (01.11.2005)
Published in Organic process research & development (01.11.2005)
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Journal Article
Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor
Wallace, Debra J, Baxter, Carl A, Brands, Karel J. M, Bremeyer, Nadine, Brewer, Sarah E, Desmond, Richard, Emerson, Khateeta M, Foley, Jennifer, Fernandez, Paul, Hu, Weifeng, Keen, Stephen P, Mullens, Peter, Muzzio, Daniel, Sajonz, Peter, Tan, Lushi, Wilson, Robert D, Zhou, George, Zhou, Guoyue
Published in Organic process research & development (15.07.2011)
Published in Organic process research & development (15.07.2011)
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Journal Article
Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor
Stewart, Gavin W, Brands, Karel M. J, Brewer, Sarah E, Cowden, Cameron J, Davies, Antony J, Edwards, John S, Gibson, Andrew W, Hamilton, Simon E, Katz, Jason D, Keen, Stephen P, Mullens, Peter R, Scott, Jeremy P, Wallace, Debra J, Wise, Christopher S
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
SPECIAL FEATURE SECTION: ASYMMETRIC SYNTHESIS ON LARGE SCALE
Federsel, Hans Jürgen, Brands, Karel M. J
Published in Organic process research & development (18.05.2007)
Published in Organic process research & development (18.05.2007)
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Journal Article
A Practical and Scaleable Synthesis of 1R,5S-Bicyclo[3.1.0]hexan-2-one: The Development of a Catalytic Lithium 2,2,6,6-Tetramethylpiperidide (LTMP) Mediated Intramolecular Cyclopropanation of (R)-1,2-Epoxyhex-5-ene
Alorati, Anthony D, Bio, Matthew M, Brands, Karel M. J, Cleator, Ed, Davies, Antony J, Wilson, Robert D, Wise, Chris S
Published in Organic process research & development (01.05.2007)
Published in Organic process research & development (01.05.2007)
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Journal Article
Development of a Scaleable Synthesis of a Partial Nicotinic Acid Receptor Agonist
Wilson, Robert D, Cleator, Ed, Ashwood, Michael S, Bio, Matthew M, Brands, Karel M. J, Davies, Antony J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Hands, David, McKeown, Arlene E, Oliver, Steven F, Reamer, Robert A, Sheen, Faye J, Stewart, Gavin W, Zhou, George X
Published in Organic process research & development (15.05.2009)
Published in Organic process research & development (15.05.2009)
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Journal Article
Practical Asymmetric Synthesis of a Non-Peptidic αvβ3 Antagonist
Keen, Stephen P, Cowden, Cameron J, Bishop, Brian C, Brands, Karel M. J, Davies, Antony J, Dolling, Ulf H, Lieberman, David R, Stewart, Gavin W
Published in Journal of organic chemistry (04.03.2005)
Published in Journal of organic chemistry (04.03.2005)
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