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"BRAM HERPERS" » "BRAM HELPERS"
Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy
Koedoot, Esmee, Wolters, Liesanne, Smid, Marcel, Stoilov, Peter, Burger, Gerhard A., Herpers, Bram, Yan, Kuan, Price, Leo S., Martens, John W. M., Le Dévédec, Sylvia E., van de Water, Bob
Published in Scientific reports (31.03.2021)
Published in Scientific reports (31.03.2021)
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Journal Article
New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
Rodrigues, Daniela, de Souza, Terezinha, Coyle, Luke, Di Piazza, Matteo, Herpers, Bram, Ferreira, Sofia, Zhang, Mian, Vappiani, Johanna, Sévin, Daniel C., Gabor, Attila, Lynch, Anthony, Chung, Seung-Wook, Saez-Rodriguez, Julio, Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M.
Published in Archives of toxicology (01.08.2021)
Published in Archives of toxicology (01.08.2021)
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Journal Article
Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids
Rodrigues, Daniela, Coyle, Luke, Füzi, Barbara, Ferreira, Sofia, Jo, Heeseung, Herpers, Bram, Chung, Seung-Wook, Fisher, Ciarán, Kleinjans, Jos C S, Jennen, Danyel, de Kok, Theo M
Published in International journal of molecular sciences (24.01.2022)
Published in International journal of molecular sciences (24.01.2022)
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Journal Article
Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment
Wink, Steven, Hiemstra, Steven, Huppelschoten, Suzanna, Danen, Erik, Niemeijer, Marije, Hendriks, Giel, Vrieling, Harry, Herpers, Bram, van de Water, Bob
Published in Chemical research in toxicology (17.03.2014)
Published in Chemical research in toxicology (17.03.2014)
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Journal Article
A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids
Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C S, Jennen, Danyel G J, de Kok, Theo M
Published in International journal of molecular sciences (17.02.2022)
Published in International journal of molecular sciences (17.02.2022)
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Journal Article
3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors
Badder, Luned M, Hollins, Andrew J, Herpers, Bram, Yan, Kuan, Ewan, Kenneth B, Thomas, Mairian, Shone, Jennifer R, Badder, Delyth A, Naven, Marc, Ashelford, Kevin E, Hargest, Rachel, Clarke, Alan R, Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S, Shaw, Paul H, Dale, Trevor C
Published in PloS one (18.08.2020)
Published in PloS one (18.08.2020)
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Journal Article
Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility
Satomaa, Tero, Pynnönen, Henna, Vilkman, Anja, Kotiranta, Titta, Pitkänen, Virve, Heiskanen, Annamari, Herpers, Bram, Price, Leo, Helin, Jari, Saarinen, Juhani
Published in Antibodies (Basel) (22.03.2018)
Published in Antibodies (Basel) (22.03.2018)
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Journal Article
Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening
Di, Zi, Herpers, Bram, Fredriksson, Lisa, Yan, Kuan, van de Water, Bob, Verbeek, Fons J, Meerman, John H N
Published in PloS one (27.12.2012)
Published in PloS one (27.12.2012)
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Journal Article
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
Hadi, Mackenzie, Dragovic, Sanja, van Swelm, Rachel, Herpers, Bram, van de Water, Bob, Russel, Frans G. M., Commandeur, Jan N. M., Groothuis, Geny M. M.
Published in Archives of toxicology (01.01.2013)
Published in Archives of toxicology (01.01.2013)
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Journal Article
High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities
Wink, Steven, Hiemstra, Steven, Herpers, Bram, van de Water, Bob
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
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Journal Article
Abstract 6315: High content screening of intestinal organoid cultures to visualize and quantify effects of drug combinations
Madej, Mariusz, Zuvirie, Cinthya Del Angel, Mateos, Jara García, Price, Leo, Yan, Kuan, Herpers, Bram
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
Ramaiahgari, Sreenivasa C., den Braver, Michiel W., Herpers, Bram, Terpstra, Valeska, Commandeur, Jan N. M., van de Water, Bob, Price, Leo S.
Published in Archives of toxicology (01.05.2014)
Published in Archives of toxicology (01.05.2014)
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Journal Article
Abstract LB-A09: Predicting PARPi sensitivity in patient derived ex vivo 3D tumor cultures
Basten, Sander, Herpers, Bram, Yan, Kuan, Vader, Willemijn, Price, Leo
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Abstract 2083: Human normal and tumor colon organoids: a 3D high content screening platform for anticancer drug development
Madej, Mariusz, Mateos, Jara Garcia, Yan, Kuan, Daszkiewicz, Lidia, Herpers, Bram, Price, Leo S.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells
Benedetti, Giulia, Fredriksson, Lisa, Herpers, Bram, Meerman, John, van de Water, Bob, de Graauw, Marjo
Published in Biochemical pharmacology (15.01.2013)
Published in Biochemical pharmacology (15.01.2013)
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Journal Article