Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N‑[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile
Werner, Stefan, Mesch, Stefanie, Hillig, Roman C, ter Laak, Antonius, Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Bräuer, Nico, Puetter, Vera, Nubbemeyer, Reinhard, Schulz, Simone, Bairlein, Michaela, Zollner, Thomas M, Steinmeyer, Andreas
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
Davenport, Adam J, Neagoe, Ioana, Bräuer, Nico, Koch, Markus, Rotgeri, Andrea, Nagel, Jens, Laux-Biehlmann, Alexis, Machet, Frederic, Coelho, Anne-Marie, Boyce, Susan, Carty, Nikisha, Gemkow, Mark J, Hess, Stephen D, Zollner, Thomas M, Fischer, Oliver M
Published in Scientific reports (06.10.2021)
Published in Scientific reports (06.10.2021)
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Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
Wortmann, Lars, Bräuer, Nico, Holton, Simon J, Irlbacher, Horst, Weiske, Jörg, Lechner, Christian, Meier, Robin, Karén, Jakob, Siöberg, Catrine Berthold, Pütter, Vera, Christ, Clara D, ter Laak, Antonius, Lienau, Philip, Lesche, Ralf, Nicke, Barbara, Cheung, Shing-Hu, Bauser, Marcus, Haegebarth, Andrea, von Nussbaum, Franz, Mumberg, Dominik, Lemos, Clara
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis
Koppitz, Marcus, Bräuer, Nico, Ter Laak, Antonius, Irlbacher, Horst, Rotgeri, Andrea, Coelho, Anne-Marie, Walter, Daryl, Steinmeyer, Andreas, Zollner, Thomas M., Peters, Michaele, Nagel, Jens
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Bäurle, Stefan, Nagel, Jens, Peters, Olaf, Bräuer, Nico, ter Laak, Antonius, Preusse, Cornelia, Rottmann, Antje, Heldmann, Dieter, Bothe, Ulrich, Blume, Thorsten, Zorn, Ludwig, Walter, Daryl, Zollner, Thomas M, Steinmeyer, Andreas, Langer, Gernot
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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13--2- 13-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO COELHO ANNE MARIE, ROTGERI ANDREA, ROTTMANN ANTJE, NAGEL JENS, DAVENPORT ADAM JAMES, NEAGOE IOANA, FISCHER OLIVER MARTIN, KLAR JUERGEN, BRAEUER NICO
Year of Publication 03.07.2023
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Year of Publication 03.07.2023
Patent
Abstract 4584: Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I and Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Nicke, Barbara, Bone, Wilhelm, Golfier, Sven, Brzezinka, Krzysztof, Kaulfuss, Stefan, Kopitz, Charlotte, Steuber, Holger, Braeuer, Nico, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Kuehnlenz, Julia, Potze, Lisette, Zanconato, Francesca, Montebaur, Anna, Pilari, Sabine, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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P2X3 억제제로서의 신규 피라졸로-피롤로-피리미딘-디온 유도체
CARR JAMES LINDSAY, SIEBENEICHER HOLGER, CONNELLY URSINYOVA NINA, KOPPITZ MARCUS, PARROTT SHELLEY ANNE, POOK ELISABETH, BRAEUER NICO, ROTGERI ANDREA, NAGEL JENS, NEUHAUS ROLAND, DAVENPORT ADAM JAMES, TOWNSEND ROBERT JAMES, FISCHER OLIVER MARTIN
Year of Publication 01.07.2020
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Year of Publication 01.07.2020
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방향족 술폰아미드 유도체
HARDAKER ELIZABETH, HERBERT SIMON ANTHONY, CLEVE ARWED, WERNER STEFAN, LISHCHYNSKYI ANTON, MESCH STEFANIE, KOCH MARKUS, OSMERS MAREN, BRAEUER NICO, DAHLLOEF HENRIK
Year of Publication 09.01.2019
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Year of Publication 09.01.2019
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SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF
GODINHO COELHO ANNE MARIE, ROTGERI ANDREA, KOPPITZ MARCUS, NAGEL JENS, PETERS MICHAELE, IRLBACHER HORST, SCHWEDE WOLFGANG, BRAEUER NICO, DAHLLOEF HENRIK
Year of Publication 30.08.2017
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Year of Publication 30.08.2017
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13--2- 13-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
GODINHO COELHO ANNE MARIE, ROTGERI ANDREA, ROTTMANN ANTJE, NAGEL JENS, DAVENPORT ADAM JAMES, NEAGOE IOANA, FISCHER OLIVER MARTIN, BRAEUER NICO
Year of Publication 14.08.2017
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Year of Publication 14.08.2017
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PHARMACEUTICAL COMPOSITION AND THE USE THEREOF, AND APPLICATION REGIME OF SAID PHARMACEUTICAL COMPOSITION FOR ON-DEMAND CONTRACEPTION
SERNO PETER, ROTGERI ANDREA, BUCHMANN BERND, ROEHN ULRIKE, TER LAAK ANTONIUS, LINDENTHAL BERNHARD, FUHRMANN ULRIKE, BRAEUER NICO, MENGEL ANNE
Year of Publication 11.02.2016
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Year of Publication 11.02.2016
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NOVEL 2H-INDAZOLES AS EP2 RECEPTOR ANTAGONISTS
ROTGERI ANDREA, BUCHMANN BERND, ROEHN ULRIKE, TER LAAK ANTONIUS, LINDENTHAL BERNHARD, BRAEUER NICO, MENGEL ANNE
Year of Publication 27.08.2014
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Year of Publication 27.08.2014
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NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
KUHNKE JOACHIM, PETERS OLAF, ZORN LUDWIG, NAGEL JENS, LANGER GERNOT, KAULFUSS STEFAN, BLUME THORSTEN, TER LAAK ANTONIUS, BRAEUER NICO
Year of Publication 12.08.2015
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Year of Publication 12.08.2015
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8-BETA-SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS
PETERS OLAF, PRELLE KATJA, FRITZEMEIER KARL HEINRICH, THIEME INA, MUHN HANS PETER, BRAEUER NICO
Year of Publication 09.04.2010
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Year of Publication 09.04.2010
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1,3-thiazol-2-yl substituted benzamides
Godinho-Coelho, Anne-Marie, Fischer, Oliver Martin, Davenport, Adam James, Nagel, Jens, Neagoe, Ioana, Klar, Juergen, Braeuer, Nico, Rotgeri, Andrea, Rottmann, Antje
Year of Publication 25.03.2022
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Year of Publication 25.03.2022
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1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
NEAGOE, IOANA, GODINHO-COELHO, ANNE-MARIE, KLAR, JUERGEN, DAVENPORT, ADAM JAMES, FISCHER, OLIVER MARTIN, NAGEL, JENS, BRAEUER, NICO, ROTGERI, ANDREA, ROTTMANN, ANTJE
Year of Publication 13.12.2021
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Year of Publication 13.12.2021
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