Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Published in Cell (11.04.2013)
Published in Cell (11.04.2013)
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Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.
Published in Cell (28.09.2012)
Published in Cell (28.09.2012)
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RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, James E., Rabadan, Raul, Basu, Uttiya
Published in Cell (07.05.2015)
Published in Cell (07.05.2015)
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Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers
Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Weintraub, Abraham S., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Published in Molecular cell (16.04.2015)
Published in Molecular cell (16.04.2015)
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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason, Neel, Benjamin G.
Published in Cell (14.01.2016)
Published in Cell (14.01.2016)
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Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
Lockwood, William W., Zejnullahu, Kreshnik, Bradner, James E., Varmus, Harold
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
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BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
Zhu, Hengrui, Bengsch, Fee, Svoronos, Nikolaos, Rutkowski, Melanie R., Bitler, Benjamin G., Allegrezza, Michael J., Yokoyama, Yuhki, Kossenkov, Andrew V., Bradner, James E., Conejo-Garcia, Jose R., Zhang, Rugang
Published in Cell reports (Cambridge) (13.09.2016)
Published in Cell reports (Cambridge) (13.09.2016)
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BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
Anand, Priti, Brown, Jonathan D., Lin, Charles Y., Qi, Jun, Zhang, Rongli, Artero, Pedro Calderon, Alaiti, M. Amer, Bullard, Jace, Alazem, Kareem, Margulies, Kenneth B., Cappola, Thomas P., Lemieux, Madeleine, Plutzky, Jorge, Bradner, James E., Haldar, Saptarsi M.
Published in Cell (01.08.2013)
Published in Cell (01.08.2013)
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.
Published in Cancer cell (09.12.2013)
Published in Cancer cell (09.12.2013)
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Small-Molecule Inhibition of BRDT for Male Contraception
Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.
Published in Cell (17.08.2012)
Published in Cell (17.08.2012)
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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis
Brown, Jonathan D., Lin, Charles Y., Duan, Qiong, Griffin, Gabriel, Federation, Alexander J., Paranal, Ronald M., Bair, Steven, Newton, Gail, Lichtman, Andrew H., Kung, Andrew L., Yang, Tianlun, Wang, Hong, Luscinskas, Francis W., Croce, Kevin J., Bradner, James E., Plutzky, Jorge
Published in Molecular cell (23.10.2014)
Published in Molecular cell (23.10.2014)
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The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
Lu, Gang, Middleton, Richard E., Sun, Huahang, Naniong, MarkVic, Ott, Christopher J., Mitsiades, Constantine S., Wong, Kwok-Kin, Bradner, James E., Kaelin, William G.
Published in Science (American Association for the Advancement of Science) (17.01.2014)
Published in Science (American Association for the Advancement of Science) (17.01.2014)
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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud
Published in Cell (10.04.2014)
Published in Cell (10.04.2014)
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Plasticity in binding confers selectivity in ligand-induced protein degradation
Nowak, Radosław P, DeAngelo, Stephen L, Buckley, Dennis, He, Zhixiang, Donovan, Katherine A, An, Jian, Safaee, Nozhat, Jedrychowski, Mark P, Ponthier, Charles M, Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D, Gray, Nathanael S, Bradner, James E, Fischer, Eric S
Published in Nature chemical biology (01.07.2018)
Published in Nature chemical biology (01.07.2018)
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Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome
Orlando, David A., Chen, Mei Wei, Brown, Victoria E., Solanki, Snehakumari, Choi, Yoon J., Olson, Eric R., Fritz, Christian C., Bradner, James E., Guenther, Matthew G.
Published in Cell reports (Cambridge) (06.11.2014)
Published in Cell reports (Cambridge) (06.11.2014)
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.
Published in Cell (14.12.2017)
Published in Cell (14.12.2017)
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Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
Remillard, David, Buckley, Dennis L., Paulk, Joshiawa, Brien, Gerard L., Sonnett, Matthew, Seo, Hyuk‐Soo, Dastjerdi, Shiva, Wühr, Martin, Dhe‐Paganon, Sirano, Armstrong, Scott A., Bradner, James E.
Published in Angewandte Chemie (International ed.) (15.05.2017)
Published in Angewandte Chemie (International ed.) (15.05.2017)
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Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability
Meng, Fei-Long, Du, Zhou, Federation, Alexander, Hu, Jiazhi, Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Meyers, Robin M., Amor, Corina, Wasserman, Caitlyn R., Neuberg, Donna, Casellas, Rafael, Nussenzweig, Michel C., Bradner, James E., Liu, X. Shirley, Alt, Frederick W.
Published in Cell (18.12.2014)
Published in Cell (18.12.2014)
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S
Published in Nature chemical biology (01.02.2018)
Published in Nature chemical biology (01.02.2018)
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