A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome
Deng, Zimu, Chong, Zhenlu, Law, Christopher S, Mukai, Kojiro, Ho, Frances O, Martinu, Tereza, Backes, Bradley J, Eckalbar, Walter L, Taguchi, Tomohiko, Shum, Anthony K
Published in The Journal of experimental medicine (02.11.2020)
Published in The Journal of experimental medicine (02.11.2020)
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Journal Article
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.
Published in Cell metabolism (08.08.2012)
Published in Cell metabolism (08.08.2012)
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Journal Article
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
Wei, Ying, Kim, Thomas J, Peng, David H, Duan, Dana, Gibbons, Don L, Yamauchi, Mitsuo, Jackson, Julia R, Le Saux, Claude J, Calhoun, Cheresa, Peters, Jay, Derynck, Rik, Backes, Bradley J, Chapman, Harold A
Published in The Journal of clinical investigation (02.10.2017)
Published in The Journal of clinical investigation (02.10.2017)
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Journal Article
Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.
Published in Cell (31.07.2014)
Published in Cell (31.07.2014)
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Journal Article
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung
Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C, Brumwell, Alexis, Chapman, Harold A, Backes, Bradley J, Perara, Gayani, Maly, Dustin J, Sheppard, Dean, Papa, Feroz R
Published in PloS one (01.01.2019)
Published in PloS one (01.01.2019)
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Journal Article
Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib
Yamashita, Yusuke, Morita, Shuhei, Hosoi, Hiroki, Kobata, Hiroshi, Kishimoto, Shohei, Ishibashi, Tatsuya, Mishima, Hiroyuki, Kinoshita, Akira, Backes, Bradley J, Yoshiura, Koh-Ichiro, Papa, Feroz R, Sonoki, Takashi, Tamura, Shinobu
Published in International journal of molecular sciences (31.08.2020)
Published in International journal of molecular sciences (31.08.2020)
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Journal Article
Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries
Harris, Jennifer L., Backes, Bradley J., Leonetti, Francesco, Mahrus, Sami, Ellman, Jonathan A., Craik, Charles S.
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2000)
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Journal Article
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
Craik, Charles S, Ellman, Jonathan A, Backes, Bradley J, Harris, Jennifer L, Leonetti, Francesco
Published in Nature biotechnology (01.02.2000)
Published in Nature biotechnology (01.02.2000)
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Journal Article
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita, Shuhei, Villalta, S Armando, Feldman, Hannah C, Register, Ames C, Rosenthal, Wendy, Hoffmann-Petersen, Ingeborg T, Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, Colon-Negron, Kevin, Meza-Acevedo, Rosa, Backes, Bradley J, Maly, Dustin J, Bluestone, Jeffrey A, Papa, Feroz R
Published in Cell metabolism (04.04.2017)
Published in Cell metabolism (04.04.2017)
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Journal Article
Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-carbamoylmethylcoumarin (ACC) Fluorophore
Maly, Dustin J., Leonetti, Francesco, Backes, Bradley J., Dauber, Deborah S., Harris, Jennifer L., Craik, Charles S., Ellman, Jonathan A.
Published in Journal of organic chemistry (08.02.2002)
Published in Journal of organic chemistry (08.02.2002)
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Journal Article
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis
Auyeung, Vincent C, Downey, Michael S, Thamsen, Maike, Wenger, Talia A, Backes, Bradley J, Sheppard, Dean, Papa, Feroz R
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2022)
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2022)
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Journal Article
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
Wang, Likun, Perera, B Gayani K, Hari, Sanjay B, Bhhatarai, Barun, Backes, Bradley J, Seeliger, Markus A, Schürer, Stephan C, Oakes, Scott A, Papa, Feroz R, Maly, Dustin J
Published in Nature chemical biology (01.12.2012)
Published in Nature chemical biology (01.12.2012)
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Journal Article
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival
Moore, Paul C, Qi, Jenny Y, Thamsen, Maike, Ghosh, Rajarshi, Peng, Justin, Gliedt, Micah J, Meza-Acevedo, Rosa, Warren, Rachel E, Hiniker, Annie, Kim, Grace E, Maly, Dustin J, Backes, Bradley J, Papa, Feroz R, Oakes, Scott A
Published in Cancer research (Chicago, Ill.) (15.12.2019)
Published in Cancer research (Chicago, Ill.) (15.12.2019)
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Journal Article
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands
Feldman, Hannah C, Tong, Michael, Wang, Likun, Meza-Acevedo, Rosa, Gobillot, Theodore A, Lebedev, Ivan, Gliedt, Micah J, Hari, Sanjay B, Mitra, Arinjay K, Backes, Bradley J, Papa, Feroz R, Seeliger, Markus A, Maly, Dustin J
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Journal Article
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
Feldman, Hannah C., Ghosh, Rajarshi, Auyeung, Vincent C., Mueller, James L., Kim, Jae-Hong, Potter, Zachary E., Vidadala, Venkata N., Perera, B. Gayani K., Olivier, Alina, Backes, Bradley J., Zikherman, Julie, Papa, Feroz R., Maly, Dustin J.
Published in Nature chemical biology (01.11.2021)
Published in Nature chemical biology (01.11.2021)
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Journal Article
Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei
Wang, Ching C., Bozdech, Zbynek, Liu, Chao-lin, Shipway, Aaron, Backes, Bradley J., Harris, Jennifer L., Bogyo, Matthew
Published in The Journal of biological chemistry (02.05.2003)
Published in The Journal of biological chemistry (02.05.2003)
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Journal Article
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita, Shuhei, Villalta, S. Armando, Feldman, Hannah C., Register, Ames C., Rosenthal, Wendy, Hoffmann-Petersen, Ingeborg T., Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, Colon-Negron, Kevin, Meza-Acevedo, Rosa, Backes, Bradley J., Maly, Dustin J., Bluestone, Jeffrey A., Papa, Feroz R.
Published in Cell metabolism (02.05.2017)
Published in Cell metabolism (02.05.2017)
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Journal Article