A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents
Qin, Tian, Cornella, Josep, Li, Chao, Malins, Lara R., Edwards, Jacob T., Kawamura, Shuhei, Maxwell, Brad D., Eastgate, Martin D., Baran, Phil S.
Published in Science (American Association for the Advancement of Science) (13.05.2016)
Published in Science (American Association for the Advancement of Science) (13.05.2016)
Get full text
Journal Article
In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies
LIFEI WANG, DONGLU ZHANG, HUMPHREYS, W. Griffith, GROSSMAN, Scott J, RAGHAVAN, Nirmala, MING YAO, LI MA, FROST, Charles A, MAXWELL, Brad D, CHEN, Shiang-Yuan, KAN HE, GOOSEN, Theunis C
Published in Drug metabolism and disposition (01.03.2010)
Published in Drug metabolism and disposition (01.03.2010)
Get full text
Journal Article
Deuterium in drug discovery: progress, opportunities and challenges
Di Martino, Rita Maria Concetta, Maxwell, Brad D, Pirali, Tracey
Published in Nature reviews. Drug discovery (01.07.2023)
Published in Nature reviews. Drug discovery (01.07.2023)
Get full text
Journal Article
Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate
Washburn, William N, Manfredi, Mark, Devasthale, Pratik, Zhao, Guohua, Ahmad, Saleem, Hernandez, Andres, Robl, Jeffrey A, Wang, Wei, Mignone, James, Wang, Zhenghua, Ngu, Khehyong, Pelleymounter, Mary Ann, Longhi, Daniel, Zhao, Rulin, Wang, Bei, Huang, Ning, Flynn, Neil, Azzara, Anthony V, Barrish, Joel C, Rohrbach, Kenneth, Devenny, James J, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen E, Harvey, Susan J, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Maxwell, Brad D, Yang, Hong, Apedo, Atsu, Gemzik, Brian, Janovitz, Evan B, Huang, Christine, Zhang, Lisa, Freeden, Chris, Murphy, Brian J
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
Get full text
Journal Article
Hydromethylation of Unactivated Olefins
Dao, Hai T, Li, Chao, Michaudel, Quentin, Maxwell, Brad D, Baran, Phil S
Published in Journal of the American Chemical Society (01.07.2015)
Published in Journal of the American Chemical Society (01.07.2015)
Get full text
Journal Article
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
Wong, Pancras C, Seiffert, Dietmar, Bird, J Eileen, Watson, Carol A, Bostwick, Jeffrey S, Giancarli, Mary, Allegretto, Nick, Hua, Ji, Harden, David, Guay, Jocelyne, Callejo, Mario, Miller, Michael M, Lawrence, R Michael, Banville, Jacques, Guy, Julia, Maxwell, Brad D, Priestley, E Scott, Marinier, Anne, Wexler, Ruth R, Bouvier, Michel, Gordon, David A, Schumacher, William A, Yang, Jing
Published in Science translational medicine (04.01.2017)
Published in Science translational medicine (04.01.2017)
Get more information
Journal Article
Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem
Czeskis, Boris, Elmore, Charles S., Haight, Anthony, Hesk, David, Maxwell, Brad D., Miller, Scott A., Raglione, Thomas, Schildknegt, Klaas, Traverse, John F., Wang, Peng
Published in Journal of labelled compounds & radiopharmaceuticals (01.09.2019)
Published in Journal of labelled compounds & radiopharmaceuticals (01.09.2019)
Get full text
Journal Article
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode
Jurica, Elizabeth A, Wu, Ximao, Williams, Kristin N, Hernandez, Andres S, Nirschl, David S, Rampulla, Richard A, Mathur, Arvind, Zhou, Min, Cao, Gary, Xie, Chunshan, Jacob, Biji, Cai, Hong, Wang, Tao, Murphy, Brian J, Liu, Heng, Xu, Carrie, Kunselman, Lori K, Hicks, Michael B, Sun, Qin, Schnur, Dora M, Sitkoff, Doree F, Dierks, Elizabeth A, Apedo, Atsu, Moore, Douglas B, Foster, Kimberly A, Cvijic, Mary Ellen, Panemangalore, Reshma, Flynn, Neil A, Maxwell, Brad D, Hong, Yang, Tian, Yuan, Wilkes, Jason J, Zinker, Bradley A, Whaley, Jean M, Barrish, Joel C, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce A
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
Get full text
Journal Article
The synthesis of [14C]4‐acetylphenylalanine, effect on cell viability, and assessment of protein incorporation in male rat hepatocytes
Maxwell, Brad D., Ly, Van, Brock, Barry, Dodge, Robert, Tirmenstein, Mark, Calvano, Jacqueline
Published in Journal of labelled compounds & radiopharmaceuticals (30.06.2017)
Published in Journal of labelled compounds & radiopharmaceuticals (30.06.2017)
Get full text
Journal Article
The synthesis of [1‐14C]2‐(1H‐tetrazol‐5‐yl)acetic acid
Maxwell, Brad D., Tran, Scott B.
Published in Journal of labelled compounds & radiopharmaceuticals (01.01.2017)
Published in Journal of labelled compounds & radiopharmaceuticals (01.01.2017)
Get full text
Journal Article
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development
Shaw, Scott A, Balasubramanian, Balu, Bonacorsi, Samuel, Cortes, Janet Caceres, Cao, Kevin, Chen, Bang-Chi, Dai, Jun, Decicco, Carl, Goswami, Animesh, Guo, Zhiwei, Hanson, Ronald, Humphreys, W. Griffith, Lam, Patrick Y. S, Li, Wenying, Mathur, Arvind, Maxwell, Brad D, Michaudel, Quentin, Peng, Li, Pudzianowski, Andrew, Qiu, Feng, Su, Shun, Sun, Dawn, Tymiak, Adrienne A, Vokits, Benjamin P, Wang, Bei, Wexler, Ruth, Wu, Dauh-Rurng, Zhang, Yingru, Zhao, Rulin, Baran, Phil S
Published in Journal of organic chemistry (17.07.2015)
Published in Journal of organic chemistry (17.07.2015)
Get full text
Journal Article
The synthesis and analysis of [phenyl-14C(U)]BMS-770767 and [13C6]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies
Maxwell, Brad D., Bonacorsi Jr, Samuel J.
Published in Journal of labelled compounds & radiopharmaceuticals (01.12.2016)
Published in Journal of labelled compounds & radiopharmaceuticals (01.12.2016)
Get full text
Journal Article
The syntheses of [14C]BMS-823778 for use in a human ADME clinical study and of [13CD3 13CD2]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite
Maxwell, Brad D., Tran, Scott B., Lago, Michael, Li, Jun, Bonacorsi Jr, Samuel J.
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2016)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2016)
Get full text
Journal Article
Correction to “Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development”
Shaw, Scott A, Balasubramanian, Balu, Bonacorsi, Samuel, Caceres Cortes, Janet, Cao, Kevin, Chen, Bang-Chi, Dai, Jun, Decicco, Carl, Goswami, Animesh, Guo, Zhiwei, Hanson, Ronald, Humphreys, W. Griffith, Lam, Patrick Y. S, Li, Wenying, Mathur, Arvind, Maxwell, Brad D, Michaudel, Quentin, Peng, Li, Pudzianowski, Andrew, Qiu, Feng, Su, Shun, Sun, Dawn, Tymiak, Adrienne A, Vokits, Benjamin P, Wang, Bei, Wexler, Ruth, Wu, Dauh-Rurng, Zhang, Yingru, Zhao, Rulin, Baran, Phil S
Published in Journal of organic chemistry (18.09.2015)
Published in Journal of organic chemistry (18.09.2015)
Get full text
Journal Article