Human commensals producing a novel antibiotic impair pathogen colonization
Zipperer, Alexander, Konnerth, Martin C, Laux, Claudia, Berscheid, Anne, Janek, Daniela, Weidenmaier, Christopher, Burian, Marc, Schilling, Nadine A, Slavetinsky, Christoph, Marschal, Matthias, Willmann, Matthias, Kalbacher, Hubert, Schittek, Birgit, Brötz-Oesterhelt, Heike, Grond, Stephanie, Peschel, Andreas, Krismer, Bernhard
Published in Nature (London) (28.07.2016)
Published in Nature (London) (28.07.2016)
Get full text
Journal Article
Chemical Predictive Modelling and Natural Product‐based Divergent Synthesis – Design of Type B PPAPs with Nanomolar Activities against MRSA
Peslalz, Philipp, Vorbach, Andreas, Bleisch, Anton, Liberini, Elisa, Kraus, Frank, Izzo, Flavia, Brötz‐Oesterhelt, Heike, Götz, Friedrich, Plietker, Bernd
Published in Chemistry : a European journal (19.08.2024)
Published in Chemistry : a European journal (19.08.2024)
Get full text
Journal Article
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
Wenzel, Michaela, Chiriac, Alina Iulia, Otto, Andreas, Zweytick, Dagmar, May, Caroline, Schumacher, Catherine, Gust, Ronald, Albada, H Bauke, Penkova, Maya, Kraemer, Ute, Erdmann, Ralf, Metzler-Nolte, Nils, Straus, Suzana K, Bremer, Erhard, Becher, Dorte, Brotz-Oesterhelt, Heike, Sahl, Hans-Georg, Bandow, Julia Elisabeth
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
Get full text
Journal Article
Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides
Saad, Hamada, Aziz, Saefuddin, Gehringer, Matthias, Kramer, Markus, Straetener, Jan, Berscheid, Anne, Brötz‐Oesterhelt, Heike, Gross, Harald
Published in Angewandte Chemie International Edition (19.07.2021)
Published in Angewandte Chemie International Edition (19.07.2021)
Get full text
Journal Article
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
Sass, Peter, Josten, Michaele, Famulla, Kirsten, Schiffer, Guido, Sahl, Hans-Georg, Hamoen, Leendert, Brötz-Oesterhelt, Heike
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2011)
Get full text
Journal Article
New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A–C, Revealed by Genome Mining of Nocardia terpenica IFM 0406
Chen, Julia, Frediansyah, Andri, Männle, Daniel, Straetener, Jan, Brötz‐Oesterhelt, Heike, Ziemert, Nadine, Kaysser, Leonard, Gross, Harald
Published in Chembiochem : a European journal of chemical biology (03.08.2020)
Published in Chembiochem : a European journal of chemical biology (03.08.2020)
Get full text
Journal Article
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability
Schilling, Nadine A., Berscheid, Anne, Schumacher, Johannes, Saur, Julian S., Konnerth, Martin C., Wirtz, Sebastian N., Beltrán‐Beleña, José M., Zipperer, Alexander, Krismer, Bernhard, Peschel, Andreas, Kalbacher, Hubert, Brötz‐Oesterhelt, Heike, Steinem, Claudia, Grond, Stephanie
Published in Angewandte Chemie International Edition (01.07.2019)
Published in Angewandte Chemie International Edition (01.07.2019)
Get full text
Journal Article
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active‐Site Inhibitor Cystargolide A
Illigmann, Astrid, Vielberg, Marie‐Theres, Lakemeyer, Markus, Wolf, Felix, Dema, Taulant, Stange, Patrik, Kuttenlochner, Wolfgang, Liebhart, Elisa, Kulik, Andreas, Staudt, Nicole D., Malik, Imran, Grond, Stephanie, Sieber, Stephan A., Kaysser, Leonard, Groll, Michael, Brötz‐Oesterhelt, Heike
Published in Angewandte Chemie International Edition (15.01.2024)
Published in Angewandte Chemie International Edition (15.01.2024)
Get full text
Journal Article
Structural insights into ClpP protease side exit pore‐opening by a pH drop coupled with substrate hydrolysis
Kim, Leehyeon, Lee, Byung‐Gil, Kim, Minki, Kim, Min Kyung, Kwon, Do Hoon, Kim, Hyunmin, Brötz‐Oesterhelt, Heike, Roh, Soung‐Hun, Song, Hyun Kyu
Published in The EMBO journal (04.07.2022)
Published in The EMBO journal (04.07.2022)
Get full text
Journal Article
Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State
Eyermann, Barbara, Meixner, Maximilian, Brötz‐Oesterhelt, Heike, Antes, Iris, Sieber, Stephan A.
Published in Chembiochem : a European journal of chemical biology (15.01.2020)
Published in Chembiochem : a European journal of chemical biology (15.01.2020)
Get full text
Journal Article
Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes
Malik, Imran T., Pereira, Rebeca, Vielberg, Marie‐Theres, Mayer, Christian, Straetener, Jan, Thomy, Dhana, Famulla, Kirsten, Castro, Helena, Sass, Peter, Groll, Michael, Brötz‐Oesterhelt, Heike
Published in Chembiochem : a European journal of chemical biology (16.07.2020)
Published in Chembiochem : a European journal of chemical biology (16.07.2020)
Get full text
Journal Article
The Cyanobacterial “Nutraceutical” Phycocyanobilin Inhibits Cysteine Protease Legumain
Wilkinson, Isabel V. L., Castro‐Falcón, Gabriel, Roda‐Serrat, Maria C., Purdy, Trevor N., Straetener, Jan, Brauny, Melanie M., Maier, Lisa, Brötz‐Oesterhelt, Heike, Christensen, Lars P., Sieber, Stephan A., Hughes, Chambers C.
Published in Chembiochem : a European journal of chemical biology (01.03.2023)
Published in Chembiochem : a European journal of chemical biology (01.03.2023)
Get full text
Journal Article
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
Kirstein, Janine, Hoffmann, Anja, Lilie, Hauke, Schmidt, Ronny, Rübsamen‐Waigmann, Helga, Brötz‐Oesterhelt, Heike, Mogk, Axel, Turgay, Kürşad
Published in EMBO molecular medicine (01.04.2009)
Published in EMBO molecular medicine (01.04.2009)
Get full text
Journal Article
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Brötz-Oesterhelt, Heike, Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Ladel, Christoph, Schroeder, Werner, Hinzen, Berthold, Raddatz, Siegfried, Paulsen, Holger, Henninger, Kerstin, Bandow, Julia E, Sahl, Hans-Georg, Labischinski, Harald
Published in Nature medicine (01.10.2005)
Published in Nature medicine (01.10.2005)
Get full text
Journal Article
The microbiome-shaping roles of bacteriocins
Heilbronner, Simon, Krismer, Bernhard, Brötz-Oesterhelt, Heike, Peschel, Andreas
Published in Nature reviews. Microbiology (01.11.2021)
Published in Nature reviews. Microbiology (01.11.2021)
Get full text
Journal Article
Absolute configuration and antibiotic activity of neosartorin from the endophytic fungus Aspergillus fumigatiaffinis
Ola, Antonius R.B., Debbab, Abdessamad, Aly, Amal H., Mandi, Attila, Zerfass, Ilka, Hamacher, Alexandra, Kassack, Matthias U., Brötz-Oesterhelt, Heike, Kurtan, Tibor, Proksch, Peter
Published in Tetrahedron letters (01.01.2014)
Published in Tetrahedron letters (01.01.2014)
Get full text
Journal Article
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
Koeninger, Louis, Osbelt, Lisa, Berscheid, Anne, Wendler, Judith, Berger, Jürgen, Hipp, Katharina, Lesker, Till R, Pils, Marina C, Malek, Nisar P, Jensen, Benjamin A H, Brötz-Oesterhelt, Heike, Strowig, Till, Jan Wehkamp
Published in Communications biology (08.01.2021)
Published in Communications biology (08.01.2021)
Get full text
Journal Article
Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis
Ola, Antonius R. B, Thomy, Dhana, Lai, Daowan, Brötz-Oesterhelt, Heike, Proksch, Peter
Published in Journal of natural products (Washington, D.C.) (22.11.2013)
Published in Journal of natural products (Washington, D.C.) (22.11.2013)
Get full text
Journal Article
Correction to “The Antibacterial Synnepyrroles from Human-associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane”
Zhang, Lei, Esquembre, Lidia Alejo, Xia, Shu-Ning, Oesterhelt, Filipp, Hughes, Chambers C., Brötz-Oesterhelt, Heike, Teufel, Robin
Published in ACS chemical biology (18.08.2023)
Published in ACS chemical biology (18.08.2023)
Get full text
Journal Article