Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
Lacey, David L., Boyle, William J., Simonet, W. Scott, Kostenuik, Paul J., Dougall, William C., Sullivan, John K., Martin, Javier San, Dansey, Roger
Published in Nature reviews. Drug discovery (01.05.2012)
Published in Nature reviews. Drug discovery (01.05.2012)
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Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches
Chang, Hwai Wen, Frey, Gerhard, Liu, Haizhen, Xing, Charles, Steinman, Lawrence, Boyle, William J., Short, Jay M.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2021)
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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy
Frey, Gerhard, Cugnetti, Ana Paula G, Liu, Haizhen, Xing, Charles, Wheeler, Christina, Chang, Hwai Wen, Boyle, William J, Short, Jay M
Published in mAbs (2024)
Published in mAbs (2024)
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Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies
Bowers, Peter M, Horlick, Robert A, Neben, Tamlyn Y, Toobian, Rachelle M, Tomlinson, Geoffrey L, Dalton, Jennifer L, Jones, Heather A, Chen, Andy, Altobell, Laurence III, Zhang, Xue, Macomber, John L, Krapf, Irina P, Wu, Betty F, McConnell, Audrey, Chau, Betty, Holland, Trevin, Berkebile, Ashley D, Neben, Steven S, Boyle, William J, King, David J
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
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Journal Article
The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development
Fata, Jimmie E, Kong, Young-Yun, Li, Ji, Sasaki, Takehiko, Irie-Sasaki, Junko, Moorehead, Roger A, Elliott, Robin, Scully, Sheila, Voura, Evelyn B, Lacey, David L, Boyle, William J, Khokha, Rama, Penninger, Josef M
Published in Cell (29.09.2000)
Published in Cell (29.09.2000)
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Journal Article
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Penninger, Josef M, Kong, Young-Yun, Yoshida, Hiroki, Sarosi, Ildiko, Tan, Hong-Lin, Timms, Emma, Capparelli, Casey, Morony, Sean, Oliveira-dos-Santos, Antonio J, Van, Gwyneth, Itie, Annick, Khoo, Wilson, Wakeham, Andrew, Dunstan, Colin R, Lacey, David L, Mak, Tak W, Boyle, William J
Published in Nature (London) (28.01.1999)
Published in Nature (London) (28.01.1999)
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Journal Article
Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock‐In Mice That Express Chimeric (Murine/Human) RANKL
Kostenuik, Paul J, Nguyen, Hung Q, McCabe, James, Warmington, Kelly S, Kurahara, Carol, Sun, Ning, Chen, Ching, Li, Luke, Cattley, Russ C, Van, Gwyneth, Scully, Shelia, Elliott, Robin, Grisanti, Mario, Morony, Sean, Tan, Hong Lin, Asuncion, Frank, Li, Xiaodong, Ominsky, Michael S, Stolina, Marina, Dwyer, Denise, Dougall, William C, Hawkins, Nessa, Boyle, William J, Simonet, William S, Sullivan, John K
Published in Journal of bone and mineral research (01.02.2009)
Published in Journal of bone and mineral research (01.02.2009)
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Journal Article
RANK-L AND RANK: T Cells, Bone Loss, and Mammalian Evolution
Theill, Lars E, Boyle, William J, Penninger, Josef M
Published in Annual review of immunology (01.01.2002)
Published in Annual review of immunology (01.01.2002)
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Journal Article
Abstract 3836: Novel conditionally active biologic anti-Axl antibody-drug conjugate demonstrates anti-tumor efficacy and improved safety profile
Chang, Cathy, Frey, Gerhard, Boyle, William J., Sharp, Leslie L., Short, Jay M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
Penninger, Josef M, Kong, Young-Yun, Feige, Ulrich, Sarosi, Iidiko, Bolon, Brad, Tafuri, Anna, Morony, Sean, Capparelli, Casey, Li, Ji, Elliott, Robin, McCabe, Susan, Wong, Thomas, Campagnuolo, Giuseppe, Moran, Erika, Bogoch, Earl R, Van, Gwyneth, Nguyen, Linh T, Ohashi, Pamela S, Lacey, David L, Fish, Eleanor, Boyle, William J
Published in Nature (London) (18.11.1999)
Published in Nature (London) (18.11.1999)
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Journal Article
B61 is a ligand for the ECK receptor protein-tyrosine kinase
Bartley, Timothy D, Hunt, Robert W, Welcher, Andrew A, Boyle, William J, Parker, Vann P, Lindberg, Richard A, Lu, Hsieng S, Colombero, Anne M, Elliott, Robin L, Guthrie, Brenda A, Holst, Paige L, Skrine, James D, Toso, Robert J, Zhang, Ming, Fernandez, Elsa, Trail, Geraldine, Varnum, Brian, Yarden, Yosef, Hunter, Tony, Fox, Gary M
Published in Nature (London) (07.04.1994)
Published in Nature (London) (07.04.1994)
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1343 Novel conditionally active bispecific HER2 x CD3 T cell engager targeting solid tumors
Cugnetti, Ana Paula G, Liu, Haizhen, McNeeley, Patricia, Lucas, Mathew, Xing, Charles, Joyner, Solimarie, Johnson, Kyrie, Woodard, Kathryn, Zhou, Wei, Chang, Cathy, Frey, Gerhard, Boyle, William J, Short, Jay M
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
1342 A novel dual CAB Nectin-4 x CD3 bispecific antibody targeting solid tumors
Cugnetti, Ana Paula G, Lucas, Mathew, Liu, Haizhen, Xing, Charles, Wang, Jing, McNeely, Patty, Joyner, Solimarie, Johnson, Kyrie, Woodard, Kathryn, Zhou, Wei, Chang, Cathy, Frey, Gerhard, Boyle, William J, Short, Jay M
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption
Hofbauer, Lorenz C., Khosla, Sundeep, Dunstan, Colin R., Lacey, David L., Boyle, William J., Riggs, B. Lawrence
Published in Journal of bone and mineral research (01.01.2000)
Published in Journal of bone and mineral research (01.01.2000)
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Journal Article
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
Min, H, Morony, S, Sarosi, I, Dunstan, C R, Capparelli, C, Scully, S, Van, G, Kaufman, S, Kostenuik, P J, Lacey, D L, Boyle, W J, Simonet, W S
Published in The Journal of experimental medicine (21.08.2000)
Published in The Journal of experimental medicine (21.08.2000)
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Journal Article
Severe B Cell Hyperplasia and Autoimmune Disease in TALL-1 Transgenic Mice
Khare, Sanjay D., Sarosi, Ildiko, Xia, Xing-Zhong, McCabe, Susan, Miner, Kent, Solovyev, Irina, Hawkins, Nessa, Kelley, Michael, Chang, David, Van, Gwyneth, Ross, Larry, Delaney, John, Wang, Ling, Lacey, David, Boyle, William J., Hsu, Hailing
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2000)
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