Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Maurer, Till, Garrenton, Lindsay S, Oh, Angela, Pitts, Keith, Anderson, Daniel J, Skelton, Nicholas J, Fauber, Benjamin P, Pan, Borlan, Malek, Shiva, Stokoe, David, Ludlam, Mary J. C, Bowman, Krista K, Wu, Jiansheng, Giannetti, Anthony M, Starovasnik, Melissa A, Mellman, Ira, Jackson, Peter K, Rudolph, Joachim, Wang, Weiru, Fang, Guowei
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
Get full text
Journal Article
Oncogenic ERBB3 Mutations in Human Cancers
Jaiswal, Bijay S., Kljavin, Noelyn M., Stawiski, Eric W., Chan, Emily, Parikh, Chaitali, Durinck, Steffen, Chaudhuri, Subhra, Pujara, Kanan, Guillory, Joseph, Edgar, Kyle A., Janakiraman, Vasantharajan, Scholz, Rolf-Peter, Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Yuan, Wenlin, Peters, Brock A., Kan, Zhengyan, Stinson, Jeremy, Mak, Michelle, Modrusan, Zora, Eigenbrot, Charles, Firestein, Ron, Stern, Howard M., Rajalingam, Krishnaraj, Schaefer, Gabriele, Merchant, Mark A., Sliwkowski, Mark X., de Sauvage, Frederic J., Seshagiri, Somasekar
Published in Cancer cell (13.05.2013)
Published in Cancer cell (13.05.2013)
Get full text
Journal Article
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation
Ma, Xiaolei, Helgason, Elizabeth, Phung, Qui T., Quan, Clifford L., Iyer, Rekha S., Lee, Michelle W., Bowman, Krista K., Starovasnik, Melissa A., Dueber, Erin C.
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Get full text
Journal Article
Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers
Parikh, Chaitali, Janakiraman, Vasantharajan, Wu, Wen-I, Foo, Catherine K, Kljavin, Noelyn M, Chaudhuri, Subhra, Stawiski, Eric, Lee, Brian, Lin, Jie, Li, Hong, Lorenzo, Maria N, Yuan, Wenlin, Guillory, Joseph, Jackson, Marlena, Rondon, Jesus, Franke, Yvonne, Bowman, Krista K, Sagolla, Meredith, Stinson, Jeremy, Wu, Thomas D, Wu, Jiansheng, Stokoe, David, Stern, Howard M, Brandhuber, Barbara J, Lin, Kui, Skelton, Nicholas J, Seshagiri, Somasekar
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2012)
Get full text
Journal Article
The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site
de Leon-Boenig, Gladys, Bowman, Krista K., Feng, Jianwen A., Crawford, Terry, Everett, Christine, Franke, Yvonne, Oh, Angela, Stanley, Mark, Staben, Steven T., Starovasnik, Melissa A., Wallweber, Heidi J.A., Wu, Jiansheng, Wu, Lawren C., Johnson, Adam R., Hymowitz, Sarah G.
Published in Structure (London) (10.10.2012)
Published in Structure (London) (10.10.2012)
Get full text
Journal Article
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Ho, Hoangdung, Shriver, Stephanie, Young, Clint, Lin, Sophia, Johnson, J. P., Wu, Ping, Li, Jun, Coons, Mary, Tam, Christine, Brillantes, Bobby, Sampang, Honorio, Mortara, Kyle, Bowman, Krista K., Clark, Kevin R., Estevez, Alberto, Xie, Zhiwei, Verschoof, Henry, Grimwood, Michael, Dehnhardt, Christoph, Andrez, Jean–Christophe, Focken, Thilo, Sutherlin, Daniel P., Safina, Brian S., Starovasnik, Melissa A., Ortwine, Daniel F., Franke, Yvonne, Cohen, Charles J., Hackos, David H., Koth, Christopher M., Payandeh, Jian
Published in Science (American Association for the Advancement of Science) (18.12.2015)
Published in Science (American Association for the Advancement of Science) (18.12.2015)
Get full text
Journal Article
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
Get full text
Journal Article
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Appleton, Brent A, Wu, Ping, Maloney, Janice, Yin, JianPing, Liang, Wei-Ching, Stawicki, Scott, Mortara, Kyle, Bowman, Krista K, Elliott, J Michael, Desmarais, William, Bazan, J Fernando, Bagri, Anil, Tessier-Lavigne, Marc, Koch, Alexander W, Wu, Yan, Watts, Ryan J, Wiesmann, Christian
Published in The EMBO journal (28.11.2007)
Published in The EMBO journal (28.11.2007)
Get full text
Journal Article
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
Get full text
Journal Article
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Published in Bioorganic & medicinal chemistry letters (15.10.2013)
Get full text
Journal Article
Potent, Selective, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin Kinase Domain Exhibiting Single Agent Antiproliferative Activity
Koehler, Michael F. T, Bergeron, Philippe, Blackwood, Elizabeth, Bowman, Krista K, Chen, Yung-Hsiang, Deshmukh, Gauri, Ding, Xiao, Epler, Jennifer, Lau, Kevin, Lee, Leslie, Liu, Lichuan, Ly, Cuong, Malek, Shiva, Nonomiya, Jim, Oeh, Jason, Ortwine, Daniel F, Sampath, Deepak, Sideris, Steve, Trinh, Lan, Truong, Tom, Wu, Jiansheng, Pei, Zhonghua, Lyssikatos, Joseph P
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
Get full text
Journal Article
Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study
Heald, Robert, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Bryan, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dominguez-Fernandez, Belen, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Jackson, Philip, Knight, Jamie, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam, Merchant, Mark, Mortara, Kyle, Purkey, Hans, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
Get full text
Journal Article
Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine
Cohen, Frederick, Bergeron, Philippe, Blackwood, Elizabeth, Bowman, Krista K, Chen, Huifen, DiPasquale, Antonio G, Epler, Jennifer A, Koehler, Michael F. T, Lau, Kevin, Lewis, Cristina, Liu, Lichuan, Ly, Cuong Q, Malek, Shiva, Nonomiya, Jim, Ortwine, Daniel F, Pei, Zhonghua, Robarge, Kirk D, Sideris, Steve, Trinh, Lan, Truong, Tom, Wu, Jiansheng, Zhao, Xianrui, Lyssikatos, Joseph P
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
Get full text
Journal Article
Oncogenic ERBB3 Mutations in Human Cancers
Jaiswal, Bijay S., Kljavin, Noelyn M., Stawiski, Eric W., Chan, Emily, Parikh, Chaitali, Durinck, Steffen, Chaudhuri, Subhra, Pujara, Kanan, Guillory, Joseph, Edgar, Kyle A., Janakiraman, Vasantharajan, Scholz, Rolf-Peter, Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Yuan, Wenlin, Peters, Brock A., Kan, Zhengyan, Stinson, Jeremy, Mak, Michelle, Modrusan, Zora, Eigenbrot, Charles, Firestein, Ron, Stern, Howard M., Rajalingam, Krishnaraj, Schaefer, Gabriele, Merchant, Mark A., Sliwkowski, Mark X., de Sauvage, Frederic J., Seshagiri, Somasekar
Published in Cancer cell (14.04.2014)
Published in Cancer cell (14.04.2014)
Get full text
Journal Article
Crystal Structure of Human Cathepsin V
Somoza, John R, Zhan, Hangjun, Bowman, Krista K, Yu, Lily, Mortara, Kyle D, Palmer, James T, Clark, James M, McGrath, Mary E
Published in Biochemistry (Easton) (17.10.2000)
Published in Biochemistry (Easton) (17.10.2000)
Get full text
Journal Article
Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation
Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Chaudhuri, Subhra, Stern, Howard M., Wang, Weiru, Kan, Zhengyan, Dbouk, Hashem A., Peters, Brock A., Waring, Paul, Dela Vega, Trisha, Kenski, Denise M., Bowman, Krista K., Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Modrusan, Zora, Stinson, Jeremy, Eby, Michael, Yue, Peng, Kaminker, Josh S., de Sauvage, Frederic J., Backer, Jonathan M., Seshagiri, Somasekar
Published in Cancer cell (08.12.2009)
Published in Cancer cell (08.12.2009)
Get full text
Journal Article
Crystal Structure of Human Cathepsin V
Somoza, John R, Zhan, Hangjun, Bowman, Krista K, Yu, Lily, Mortara, Kyle D, Palmer, James T, Clark, James M, McGrath, Mary E
Published in Biochemistry (Easton) (03.04.2001)
Published in Biochemistry (Easton) (03.04.2001)
Get full text
Journal Article
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
Jaiswal, Bijay S, Janakiraman, Vasantharajan, Kljavin, Noelyn M, Chaudhuri, Subhra, Stern, Howard M, Wang, Weiru, Kan, Zhengyan, Dbouk, Hashem A, Peters, Brock A, Waring, Paul, Dela Vega, Trisha, Kenski, Denise M, Bowman, Krista K, Lorenzo, Maria, Li, Hong, Wu, Jiansheng, Modrusan, Zora, Stinson, Jeremy, Eby, Michael, Yue, Peng, Kaminker, Josh S, de Sauvage, Frederic J, Backer, Jonathan M, Seshagiri, Somasekar
Published in Cancer cell (08.12.2009)
Published in Cancer cell (08.12.2009)
Get full text
Journal Article