SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
NARE, Bakela, WRING, Stephen, HUSSAIN, Ali, JARNAGIN, Kurt, JENKS, Matthew, KAISER, Marcel, MERCER, Luke, MEJIA, Elena, NOE, Andy, ORR, Matt, PARHAM, Robin, PLATTNER, Jacob, BACCHI, Cyrus, RANDOLPH, Ryan, RATTENDI, Donna, REWERTS, Cindy, SLIGAR, Jessica, YARLETT, Nigel, DON, Robert, JACOBS, Robert, BEAUDET, Beth, BOWLING, Tana, BRUN, Reto, DAITAO CHEN, DING, Charles, FREUND, Yvonne, GAUKEL, Eric
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis
WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT
Published in Parasitology (01.01.2014)
Published in Parasitology (01.01.2014)
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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach
Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Published in PLoS neglected tropical diseases (08.02.2011)
Published in PLoS neglected tropical diseases (08.02.2011)
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Journal Article
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Van Voorhis, Wesley C, Adams, John H, Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H, Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T, Avery, Simon V, Avery, Vicky M, Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E, Boyom, Fabrice F, Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R, Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L, Colón-López, Daisy D, Corbett, Yolanda, Crowther, Gregory J, Cowan, Noemi, D'Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L, Du, Alan Y, Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T, Fernández Robledo, José A, Fidock, David A, Florent, Isabelle, Fokou, Patrick V T, Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M, Guha, Rajarshi, Guiguemde, W Armand, Gural, Nil, Guy, R Kiplin, Hansen, Michael A E, Hanson, Kirsten K, Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B, Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A, Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T, Jiang, Rays H Y, Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P, Kyle, Dennis E, Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M, Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I, Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu
Published in PLoS pathogens (01.07.2016)
Published in PLoS pathogens (01.07.2016)
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Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents
Qiao, Zhitao, Wang, Qi, Zhang, Fenglong, Wang, Zhongli, Bowling, Tana, Nare, Bakela, Jacobs, Robert T, Zhang, Jiong, Ding, Dazhong, Liu, Yangang, Zhou, Huchen
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Journal Article
Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis
Bowling, Tana, Mercer, Luke, Don, Robert, Jacobs, Robert, Nare, Bakela
Published in International journal for parasitology -- drugs and drug resistance (01.12.2012)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2012)
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Journal Article
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei
Perales, Joe B., Freeman, Jennifer, Bacchi, Cyrus J., Bowling, Tana, Don, Robert, Gaukel, Eric, Mercer, Luke, Moore III, Joseph A., Nare, Bakela, Nguyen, Tien M., Noe, Robert A., Randolph, Ryan, Rewerts, Cindy, Wring, Stephen A., Yarlett, Nigel, Jacobs, Robert T.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis: e1151
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
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Journal Article