Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
Carty, Michael, Kearney, Jay, Shanahan, Katharine A., Hams, Emily, Sugisawa, Ryoichi, Connolly, Dympna, Doran, Ciara G., Muñoz-Wolf, Natalia, Gürtler, Claudia, Fitzgerald, Katherine A., Lavelle, Ed C., Fallon, Padraic G., Bowie, Andrew G.
Published in Immunity (Cambridge, Mass.) (18.06.2019)
Published in Immunity (Cambridge, Mass.) (18.06.2019)
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SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter
Gürtler, Claudia, Carty, Michael, Kearney, Jay, Schattgen, Stefan A, Ding, Aihao, Fitzgerald, Katherine A, Bowie, Andrew G
Published in The Journal of immunology (1950) (15.05.2014)
Published in The Journal of immunology (1950) (15.05.2014)
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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation
Gu, Feng, Krüger, Aileen, Roggenkamp, Hannes G, Alpers, Rick, Lodygin, Dmitri, Jaquet, Vincent, Möckl, Franziska, Hernandez C, Lola C, Winterberg, Kai, Bauche, Andreas, Rosche, Anette, Grasberger, Helmut, Kao, John Y, Schetelig, Daniel, Werner, René, Schröder, Katrin, Carty, Michael, Bowie, Andrew G, Huber, Samuel, Meier, Chris, Mittrücker, Hans-Willi, Heeren, Joerg, Krause, Karl-Heinz, Flügel, Alexander, Diercks, Björn-Philipp, Guse, Andreas H
Published in Science signaling (16.11.2021)
Published in Science signaling (16.11.2021)
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Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
Muñoz-Wolf, Natalia, Ward, Ross W, Hearnden, Claire H, Sharp, Fiona A, Geoghegan, Joan, O'Grady, Katie, McEntee, Craig P, Shanahan, Katharine A, Guy, Coralie, Bowie, Andrew G, Campbell, Matthew, Roces, Carla B, Anderluzzi, Giulia, Webb, Cameron, Perrie, Yvonne, Creagh, Emma, Lavelle, Ed C
Published in Cell reports. Medicine (17.01.2023)
Published in Cell reports. Medicine (17.01.2023)
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Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α
Flannery, Sinead M., Keating, Sinead E., Szymak, Joanna, Bowie, Andrew G.
Published in The Journal of biological chemistry (08.07.2011)
Published in The Journal of biological chemistry (08.07.2011)
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Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors
DiPerna, Gary, Stack, Julianne, Bowie, Andrew G., Boyd, Annemarie, Kotwal, Girish, Zhang, Zhouning, Arvikar, Sheila, Latz, Eicke, Fitzgerald, Katherine A., Marshall, William L.
Published in The Journal of biological chemistry (27.08.2004)
Published in The Journal of biological chemistry (27.08.2004)
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
O'Neill, Luke A. J, Fitzgerald, Katherine A, Palsson-McDermott, Eva M, Bowie, Andrew G, Jefferies, Caroline A, Mansell, Ashley S, Brady, Gareth, Brint, Elizabeth, Dunne, Aisling, Gray, Pearl, Harte, Mary T, McMurray, Diane, Smith, Dirk E, Sims, John E, Bird, Timothy A
Published in Nature (London) (06.09.2001)
Published in Nature (London) (06.09.2001)
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Poxviral Protein A52 Stimulates p38 Mitogen-activated Protein Kinase (MAPK) Activation by Causing Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Self-association Leading to Transforming Growth Factor β-activated Kinase 1 (TAK1) Recruitment
Stack, Julianne, Hurst, Tara P., Flannery, Sinead M., Brennan, Kiva, Rupp, Sebastian, Oda, Shun-ichiro, Khan, Amir R., Bowie, Andrew G.
Published in The Journal of biological chemistry (22.11.2013)
Published in The Journal of biological chemistry (22.11.2013)
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A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance
Wang, Hui, El Maadidi, Souhayla, Fischer, Janett, Grabski, Elena, Dickhöfer, Sabine, Klimosch, Sascha, Flannery, Sinead M., Filomena, Angela, Wolz, Olaf‐Oliver, Schneiderhan‐Marra, Nicole, Löffler, Markus W., Wiese, Manfred, Pichulik, Tica, Müllhaupt, Beat, Semela, David, Dufour, Jean‐François, Bochud, Pierre‐Yves, Bowie, Andrew G., Kalinke, Ulrich, Berg, Thomas, Weber, Alexander N.R.
Published in Hepatology (Baltimore, Md.) (01.11.2015)
Published in Hepatology (Baltimore, Md.) (01.11.2015)
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Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3
Kalverda, Arnout P., Thompson, Gary S., Vogel, Andre, Schröder, Martina, Bowie, Andrew G., Khan, Amir R., Homans, Steve W.
Published in Journal of molecular biology (23.01.2009)
Published in Journal of molecular biology (23.01.2009)
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A Coding IRAK2 Protein Variant Compromises Toll-like receptor (TLR) Signaling and Is Associated with Colorectal Cancer Survival
Wang, Hui, Flannery, Sinead M., Dickhöfer, Sabine, Huhn, Stefanie, George, Julie, Kubarenko, Andriy V., Lascorz, Jesus, Bevier, Melanie, Willemsen, Joschka, Pichulik, Tica, Schafmayer, Clemens, Binder, Marco, Manoury, Bénédicte, Paludan, Søren R., Alarcon-Riquelme, Marta, Bowie, Andrew G., Försti, Asta, Weber, Alexander N.R.
Published in The Journal of biological chemistry (15.08.2014)
Published in The Journal of biological chemistry (15.08.2014)
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Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection
Boughan, Parjeet K, Argent, Richard H, Body-Malapel, Mathilde, Park, Jong-Hwan, Ewings, Katie E, Bowie, Andrew G, Ong, Shao Jin, Cook, Simon J, Sorensen, Ole E, Manzo, Barbara A, Inohara, Naohiro, Klein, Nigel J, Nuñez, Gabriel, Atherton, John C, Bajaj-Elliott, Mona
Published in The Journal of biological chemistry (28.04.2006)
Published in The Journal of biological chemistry (28.04.2006)
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Recognition of herpesviruses by the innate immune system
Paludan, Soren R, Bowie, Andrew G, Horan, Kristy A, Fitzgerald, Katherine A
Published in Nature reviews. Immunology (01.08.2013)
Published in Nature reviews. Immunology (01.08.2013)
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Viral Activation of Macrophages through TLR-Dependent and -Independent Pathways
Malmgaard, Lene, Melchjorsen, Jesper, Bowie, Andrew G, Mogensen, Soren C, Paludan, Soren R
Published in The Journal of immunology (1950) (01.12.2004)
Published in The Journal of immunology (1950) (01.12.2004)
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Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake
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