Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer
Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin
Hickson, J, Ackler, S, Klaubert, D, Bouska, J, Ellis, P, Foster, K, Oleksijew, A, Rodriguez, L, Schlessinger, S, Wang, B, Frost, D
Published in Cell death and differentiation (01.06.2010)
Published in Cell death and differentiation (01.06.2010)
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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
Luo, Yan, Shoemaker, Alexander R, Liu, Xuesong, Woods, Keith W, Thomas, Sheela A, de Jong, Ron, Han, Edward K, Li, Tongmei, Stoll, Vincent S, Powlas, Jessica A, Oleksijew, Anatol, Mitten, Michael J, Shi, Yan, Guan, Ran, McGonigal, Thomas P, Klinghofer, Vered, Johnson, Eric F, Leverson, Joel D, Bouska, Jennifer J, Mamo, Mulugeta, Smith, Richard A, Gramling-Evans, Emily E, Zinker, Bradley A, Mika, Amanda K, Nguyen, Phong T, Oltersdorf, Tilman, Rosenberg, Saul H, Li, Qun, Giranda, Vincent L
Published in Molecular cancer therapeutics (01.06.2005)
Published in Molecular cancer therapeutics (01.06.2005)
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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
Albert, Daniel H, Tapang, Paul, Magoc, Terrance J, Pease, Lori J, Reuter, David R, Wei, Ru-Qi, Li, Junling, Guo, Jun, Bousquet, Peter F, Ghoreishi-Haack, Nayereh S, Wang, Baole, Bukofzer, Gail T, Wang, Yi-Chun, Stavropoulos, Jason A, Hartandi, Kresna, Niquette, Amanda L, Soni, Nirupama, Johnson, Eric F, McCall, J Owen, Bouska, Jennifer J, Luo, Yanping, Donawho, Cherrie K, Dai, Yujia, Marcotte, Patrick A, Glaser, Keith B, Michaelides, Michael R, Davidsen, Steven K
Published in Molecular cancer therapeutics (01.04.2006)
Published in Molecular cancer therapeutics (01.04.2006)
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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Miyashiro, Julie, Woods, Keith W., Park, Chang H., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Luo, Yan, Fry, Elizabeth H., Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor
Dai, Yujia, Hartandi, Kresna, Ji, Zhiqin, Ahmed, Asma A, Albert, Daniel H, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Harris, Christopher M, Hickman, Dean, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Martin, Ruth L, Olson, Amanda M, Osterling, Donald J, Pease, Lori J, Soni, Niru B, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Reuter, David R, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Journal Article
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases
McClellan, William J., Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Magoc, Terry J., Marcotte, Patrick A., Osterling, Donald J., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia
Shankar, Deepa B., Li, Junling, Tapang, Paul, Owen McCall, J., Pease, Lori J., Dai, Yujia, Wei, Ru-Qi, Albert, Daniel H., Bouska, Jennifer J., Osterling, Donald J., Guo, Jun, Marcotte, Patrick A., Johnson, Eric F., Soni, Niru, Hartandi, Kresna, Michaelides, Michael R., Davidsen, Steven K., Priceman, Saul J., Chang, Jenny C., Rhodes, Katrin, Shah, Neil, Moore, Theodore B., Sakamoto, Kathleen M., Glaser, Keith B.
Published in Blood (15.04.2007)
Published in Blood (15.04.2007)
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Identification of genes that confer tumor cell resistance to the Aurora B kinase inhibitor, AZD1152
Guo, J, Anderson, M G, Tapang, P, Palma, J P, Rodriguez, L E, Niquette, A, Li, J, Bouska, J J, Wang, G, Semizarov, D, Albert, D H, Donawho, C K, Glaser, K B, Shah, O J
Published in The pharmacogenomics journal (01.04.2009)
Published in The pharmacogenomics journal (01.04.2009)
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Journal Article
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer
Zhu, Gui-Dong, Gong, Jianchun, Gandhi, Viraj B., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Donawho, Cherrie K., Ellis, Paul A, Bouska, Jennifer J., Osterling, Donald J., Olson, Amanda M., Park, Chang, Luo, Yan, Shoemaker, Alexander, Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry (01.08.2012)
Published in Bioorganic & medicinal chemistry (01.08.2012)
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Journal Article
The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo
PALMA, Joann P, RODRIGUEZ, Luis E, XUESONG LIU, OLSON, Amanda, SALTARELLI, Mary J, YAN SHI, STAVROPOULOS, Jason A, ZHU, Gui-Dong, PENNING, Thomas D, YAN LUO, GIRANDA, Vincent L, ROSENBERG, Saul H, BONTCHEVA-DIAZ, Velitchka D, FROST, David J, DONAWHO, Cherrie K, BOUSKA, Jennifer J, BUKOFZER, Gail, COLON-LOPEZ, Milagros, RAN GUAN, JARVIS, Kenneth, JOHNSON, Eric F, KLINGHOFER, Vered
Published in Anticancer research (01.09.2008)
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Published in Anticancer research (01.09.2008)
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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors
Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Relationships among body condition score, milk yield and reproduction in Czech Fleckvieh cows
Jilek, F.,Ceska Zemedelska Univ., Prague (Czech Republic). Katedra Veterinarnich Disciplin, Pytloun, P.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Kubesova, M.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Stipkova, M.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Bouska, J.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Volek, J.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Frelich, J.,Jihoceska Univ., Ceske Budejovice (Czech Republic). Katedra Specialni Zootechniky, Rajmon, R.,Ceska Zemedelska Univ., Prague (Czech Republic). Katedra Veterinarnich Disciplin
Published in Czech Journal of Animal Science (01.09.2008)
Published in Czech Journal of Animal Science (01.09.2008)
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Journal Article
Analysis of the phenotypic relationships between type traits and functional survival in Czech Fleckvieh cows
Zavadilova, L.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Stipkova, M.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Nemcova, E.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Bouska, J.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic), Matejickova, J.,Vyzkumny Ustav Zivocisne Vyroby, Prague (Czech Republic)
Published in Czech Journal of Animal Science (01.12.2009)
Published in Czech Journal of Animal Science (01.12.2009)
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Journal Article
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors
Dai, Yujia, Hartandi, Kresna, Soni, Niru B., Pease, Lori J., Reuter, David R., Olson, Amanda M., Osterling, Donald J., Doktor, Stella Z., Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors
Ji, Zhiqin, Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Soni, Nirupama B., Magoc, Terry J., Stewart, Kent D., Wei, Ru-Qi, Davidsen, Steve K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Journal Article
Trifluoromethyl ketones as inhibitors of histone deacetylase
Frey, Robin R., Wada, Carol K., Garland, Robert B., Curtin, Michael L., Michaelides, Michael R., Li, Junling, Pease, Lori J., Glaser, Keith B., Marcotte, Patrick A., Bouska, Jennifer J., Murphy, Shannon S., Davidsen, Steven K.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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